Multi-focused psychosocial residential rehabilitation interventions improve quality of life among cancer survivors: a community-based controlled trial

BackgroundEven though multi-focused psychosocial residence rehabilitation intervention (MPRRI) programs are widely implemented by the Shanghai Cancer Rehabilitation Club, these programs have not been rigorously evaluated. In this study, we evaluated the effects of a 21-day MPRRI program, on the quality of life (QoL) among cancer survivors.MethodsA total of 388 cancer patients were enrolled to either receive the 21-day MPRRI (n = 129) intervention or a waiting-list comparison (WLC) intervention (n = 259). The intervention group was offered community-based 21-day MPRRI program, combining supportive-expressive group, cognitive-behavioral therapy, and Guolin Qigong. QoL was measured using the European Organization for Research and Treatment Quality of Life Version 3 Questionnaire. Multivariable linear models were used to compare changes in QoL values between the two groups.ResultsAfter adjustment for the QoL score and other covariates at baseline, there was no significant difference in global health status (mean = 3.8, 95% CI − 1.3–9.0, P = 0.14) between the two groups after 6 months intervention. While compared with the WLC group, the intervention group showed significant improvements in the QoL score (all P < 0.05); however, there were no clinically relevant changes in subscales including emotional functioning (ES = 0.58), cognitive functioning (ES = 0.53), pain (ES = 0.52), physical functioning (ES = 0.36), and insomnia (ES = 0.30).ConclusionsThese preliminary results suggest the MPRRI program is both feasible and acceptable intervention for cancer survivors in community settings and is effective in significant improving QoL above.

[1]  N. Aaronson,et al.  Efficacy of cognitive behavioral therapy and physical exercise in alleviating treatment-induced menopausal symptoms in patients with breast cancer: results of a randomized, controlled, multicenter trial. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[2]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[3]  D. Osoba,et al.  Interpreting the significance of changes in health-related quality-of-life scores. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  J. Coebergh,et al.  Population‐based cancer registries for quality‐of‐life research , 2013, Cancer.

[5]  James F Sallis,et al.  Sport and exercise as contributors to the health of nations , 2012, The Lancet.

[6]  H. Okamura Importance of rehabilitation in cancer treatment and palliative medicine. , 2011, Japanese journal of clinical oncology.

[7]  H. Jim,et al.  Psychosocial Interventions for Anxiety and Depression in Adult Cancer Patients: Achievements and Challenges , 2008, CA: a cancer journal for clinicians.

[8]  C. Kirschbaum,et al.  Qigong improves quality of life in women undergoing radiotherapy for breast cancer , 2013, Cancer.

[9]  M. Thun,et al.  American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer With Healthy Food Choices and Physical Activity , 2002, CA: a cancer journal for clinicians.

[10]  Jacob Cohen Statistical Power Analysis for the Behavioral Sciences , 1969, The SAGE Encyclopedia of Research Design.

[11]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[12]  N. Lin,et al.  Informational needs and the quality of life of patients in their first year after metastatic breast cancer diagnosis. , 2014, The Journal of community and supportive oncology.

[13]  R. Newton,et al.  Living with prostate cancer: randomised controlled trial of a multimodal supportive care intervention for men with prostate cancer , 2011, BMC Cancer.

[14]  Haiyi Xie,et al.  Multilevel Models: Applications Using SAS , 2011 .

[15]  P. Krustrup,et al.  Community-Based Recreational Football: A Novel Approach to Promote Physical Activity and Quality of Life in Prostate Cancer Survivors , 2014, International journal of environmental research and public health.

[16]  Alisa J. Stephens,et al.  Mindfulness-based stress reduction compared with cognitive behavioral therapy for the treatment of insomnia comorbid with cancer: a randomized, partially blinded, noninferiority trial. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  Jun Wang,et al.  Challenges to effective cancer control in China, India, and Russia. , 2014, The Lancet. Oncology.

[18]  Stacey A. Passalacqua,et al.  Who benefits from a psychosocial counselling versus educational intervention to improve psychological quality of life in prostate cancer survivors? , 2013, Psychology & health.

[19]  M. Thun,et al.  American Cancer Society guidelines on nutrition and physical activity for cancer prevention , 2002, CA: a cancer journal for clinicians.

[20]  D. Osoba,et al.  The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. , 1993, Journal of the National Cancer Institute.

[21]  C. Meade,et al.  Effects of a brief multimedia psychoeducational intervention on the attitudes and interest of patients with cancer regarding clinical trial participation: a multicenter randomized controlled trial. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[22]  A. Jemal,et al.  Global cancer statistics, 2012 , 2015, CA: a cancer journal for clinicians.

[23]  Y. Qiao,et al.  [Three-year follow-up results of visual inspection with acetic acid/Lugol's iodine (VIA/VILI) used as an alternative screening method for cervical cancer in rural areas]. , 2010, Chinese journal of cancer.

[24]  Andrew Bottomley,et al.  EORTC QLQ-C30 Scoring Manual , 1995 .

[25]  N. Rankin,et al.  Clinical practice guidelines for the psychosocial care of adults with cancer , 2005, Psycho-oncology.

[26]  L. V. van de Poll-Franse,et al.  Health-related quality of life among cancer patients in their last year of life: results from the PROFILES registry , 2018, Supportive Care in Cancer.

[27]  B. Hahm,et al.  Effect of brief psychoeducation using a tablet PC on distress and quality of life in cancer patients undergoing chemotherapy: a pilot study , 2014, Psycho-oncology.

[28]  R. Elswick,et al.  Guided Imagery for Stress and Symptom Management in Pregnant African American Women , 2014, Evidence-based complementary and alternative medicine : eCAM.

[29]  T. Ostermann,et al.  Arts Therapies for Anxiety, Depression, and Quality of Life in Breast Cancer Patients: A Systematic Review and Meta-Analysis , 2014, Evidence-based complementary and alternative medicine : eCAM.

[30]  J. Cook,et al.  Results of a randomized controlled trial of mental illness self-management using Wellness Recovery Action Planning. , 2012, Schizophrenia bulletin.

[31]  G. Kemmler,et al.  Is the toxicity of adjuvant aromatase inhibitor therapy underestimated? Complementary information from patient-reported outcomes (PROs) , 2011, Breast Cancer Research and Treatment.

[32]  B. Mullan,et al.  Psychosocial interventions and quality of life in gynaecological cancer patients: a systematic review , 2009, Psycho-oncology.

[33]  A. Jemal,et al.  Cancer statistics in China, 2015 , 2016, CA: a cancer journal for clinicians.

[34]  P. Ganz Why and how to study the fate of cancer survivors: observations from the clinic and the research laboratory. , 2003, European journal of cancer.

[35]  K. Choi,et al.  Social support and quality of life among Chinese breast cancer survivors: findings from a mixed methods study. , 2013, European journal of oncology nursing : the official journal of European Oncology Nursing Society.

[36]  J. Tomasone,et al.  Exercise for people with cancer: a systematic review. , 2017, Current oncology.

[37]  C. Bokemeyer,et al.  Anxiety and depression in caregivers of terminally ill cancer patients: impact on their perspective of the patients' symptom burden. , 2013, Journal of palliative medicine.

[38]  P. Mcgrath Findings from an educational support course for patients with leukemia. , 1999, Cancer practice.

[39]  Jie He,et al.  Annual report on status of cancer in China, 2011. , 2015, Chinese journal of cancer research = Chung-kuo yen cheng yen chiu.

[40]  A. Ek,et al.  A substantive theory of quality of life of adults with chronic leukaemia. , 1997, International journal of nursing studies.

[41]  R. Serlin,et al.  An individualized intervention to overcome patient-related barriers to pain management in women with gynecologic cancers. , 2000, Research in nursing & health.

[42]  K. Courneya,et al.  American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. , 2010, Medicine and science in sports and exercise.

[43]  R. Masters,et al.  Effects of a 6-month Tai Chi Qigong program on arterial hemodynamics and functional aerobic capacity in survivors of nasopharyngeal cancer , 2014, Journal of Cancer Survivorship.

[44]  M. Urken,et al.  Quality of life after thyroid cancer: An assessment of patient needs and preferences for information and support , 2008, Journal of Cancer Education.

[45]  J. Armer,et al.  Nonpharmacologic supportive strategies to promote quality of life in patients experiencing cancer-related fatigue: a systematic review. , 2011, Clinical journal of oncology nursing.

[46]  W. Roberts,et al.  American College of Sports Medicine roundtable on hydration and physical activity: Consensus statements , 2005, Current sports medicine reports.

[47]  L. Nail,et al.  Self-care and breast cancer recovery. , 1998, Cancer practice.

[48]  E. T. Schroeder,et al.  Randomized controlled trial to evaluate the effects of combined progressive exercise on metabolic syndrome in breast cancer survivors: rationale, design, and methods , 2014, BMC Cancer.

[49]  Duncan J Macfarlane,et al.  Physical activity for cancer survivors: meta-analysis of randomised controlled trials , 2012, BMJ : British Medical Journal.

[50]  D. Sheffield,et al.  The effect of creative psychological interventions on psychological outcomes for adult cancer patients: a systematic review of randomised controlled trials , 2015, Psycho-oncology.

[51]  J. Tomasone,et al.  Moving guidelines into action: a report from Cancer Care Ontario’s event Let’s Get Moving: Exercise and Rehabilitation for Cancer Patients , 2017 .