Isotopic analyses by ICP-MS in clinical samples

This critical review focuses on inductively coupled plasma mass spectrometry (ICP-MS) based applications for isotope abundance ratio measurements in various clinical samples relevant to monitoring occupational or environmental exposure, human provenancing and reconstruction of migration pathways as well as metabolic research. It starts with a brief overview of recent advances in ICP-MS instrumentation, followed by selected examples that cover the fields of accurate analyte quantification using isotope dilution, tracer studies in nutrition and toxicology, and areas relying upon natural or man-made variations in isotope abundance ratios (Pb, Sr, actinides and stable heavy elements). Finally, some suggestions on future developments in the field are provided.

[1]  L. Hooper,et al.  Methods of assessment of copper status in humans: a systematic review. , 2009, The American journal of clinical nutrition.

[2]  F. Albarède,et al.  Bodily variability of zinc natural isotope abundances in sheep. , 2010, Rapid communications in mass spectrometry : RCM.

[3]  P. Outridge,et al.  Stable lead isotope characteristics of lead ore deposits of environmental significance , 2000 .

[4]  P. Stokes,et al.  Lithium isotopes: differential effects on renal function and histology. , 2001, Bipolar disorders.

[5]  G. Russ,et al.  Isotopic ratio measurements with an inductively coupled plasma source mass spectrometer , 1987 .

[6]  R. Barnes,et al.  Identification of potential environmental sources of childhood lead poisoning by inductively coupled plasma mass spectrometry. Verification and case studies , 1990 .

[7]  Dominique Weis,et al.  Evaluation of zinc, cadmium and lead isotope fractionation during smelting and refining. , 2010, The Science of the total environment.

[8]  Jean-Claude Wolff,et al.  Detection of counterfeit antiviral drug Heptodin and classification of counterfeits using isotope amount ratio measurements by multicollector inductively coupled plasma mass spectrometry (MC-ICPMS) and isotope ratio mass spectrometry (IRMS). , 2009, Science & justice : journal of the Forensic Science Society.

[9]  K. Cockell,et al.  Isotope Ratio Measurements of Iron in Blood Samples by Multi-collector ICP-MS to Support Nutritional Investigations in Humans , 2008, Biological Trace Element Research.

[10]  I. Rodushkin,et al.  Isotopic variations of Zn in biological materials. , 2004, Analytical chemistry.

[11]  M. Janghorbani,et al.  Application of ICP-MS to accurate isotopic analysis for human metabolic studies , 1987 .

[12]  M. L. Cozzella,et al.  Use of ICP-MS with different analytical techniques to investigate uranium, thorium and plutonium in urine in a case of radiological emergency , 2004 .

[13]  C. Veillon,et al.  Determination of selenium in biological materials by stable isotope dilution gas chromatography-mass spectrometry. , 1981, Analytical chemistry.

[14]  M. Campbell.  2. Isotope Dilution analysis and ICP-MS: An analyst's dream ? , 1995 .

[15]  F. Vanhaecke,et al.  Precise Measurement of Isotope Ratios with a Double-Focusing Magnetic Sector ICP Mass Spectrometer. , 1996, Analytical chemistry.

[16]  H. R. Krouse,et al.  Thermodynamic properties and geochemistry of isotopic compounds of selenium , 1962 .

[17]  J. D. Fassett,et al.  Development of isotope dilution cold vapor inductively coupled plasma mass spectrometry and its application to the certification of mercury in NIST standard reference materials. , 2001, Analytical chemistry.

[18]  S. Tanner,et al.  Effect of collisional damping and reactions in a dynamic reaction cell on the precision of isotope ratio measurements , 2000 .

[19]  G. Kamenov.  High-precision Pb isotopic measurements of teeth and environmental samples from Sofia (Bulgaria): insights for regional lead sources and possible pathways to the human body , 2008 .

[20]  K. Irgolic,et al.  The potential of inductively coupled plasma mass spectrometry (ICP-MS) for the simultaneous determination of trace elements in whole blood, plasma and serum. , 1999, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[21]  P. Schramel.  Determination of 235U and 238U in urine samples using sector field inductively coupled plasma mass spectrometry. , 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[22]  K. Simon,et al.  Interlaboratory comparison of mass spectrometric methods for lead isotopes and trace elements in NIST SRM 1400 Bone Ash , 1998 .

[23]  W. Andrews,et al.  DETERMINATION OF NATURAL AND DEPLETED URANIUM IN URINE AT THE PPT LEVEL: AN INTERLABORATORY ANALYTICAL EXERCISE , 2006, Health physics.

[24]  B. Gulson,et al.  Contribution of lead from calcium supplements to blood lead. , 2001, Environmental health perspectives.

[25]  F. Vanhaecke,et al.  Lead isotopic analysis of infant bone tissue dating from the Roman era via multicollector ICP–mass spectrometry , 2008, Analytical and Bioanalytical Chemistry.

[26]  Stephen Kiser,et al.  Automated flow injection system using extraction chromatography for the determination of plutonium in urine by inductively coupled plasma mass spectrometry , 2008 .

[27]  S. Maxwell,et al.  Rapid determination of actinides in urine by inductively coupled plasma mass spectrometry and alpha spectrometry: a hybrid approach. , 2009, Talanta.

[28]  R. Russell,et al.  Use of a stable copper isotope (65Cu) in the differential diagnosis of Wilson's disease. , 1995, Clinical science.

[29]  E. Evans,et al.  Determination of actinides in environmental and biological samples using high-performance chelation ion chromatography coupled to sector-field inductively coupled plasma mass spectrometry. , 2001, Journal of chromatography. A.

[30]  J. Andrade,et al.  Minimizing interferences in the quantitative multielement analysis of trace elements in biological fluids by inductively coupled plasma mass spectrometry. , 1997, Clinical chemistry.

[31]  B. Chung,et al.  Isotope-Dilution Mass Spectrometry for Quantification of Urinary Active Androgens Separated by Gas Chromatography , 2010 .

[32]  B. Sharp,et al.  Development of a high-resolution ICP-MS method, suitable for the measurement of iron and iron isotope ratios in acid digests of faecal samples from a human nutrition study , 2002 .

[33]  H. Hintelmann,et al.  Comparing the precision of selenium isotope ratio measurements using collision cell and sector field inductively coupled plasma mass spectrometry. , 2007, Talanta.

[34]  M. Chiba,et al.  Precise Zn Isotopic Ratio Measurements of Human Red Blood Cell and Hair Samples by Multiple Collector-ICP-Mass Spectrometry , 2005, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[35]  J. Yoshinaga.  Isotope ratio analysis of lead in biological materials by inductively coupled plasma mass spectrometry. , 1996, The Tohoku journal of experimental medicine.

[36]  I. Rodushkin,et al.  The use of Pt guard electrode in inductively coupled plasma sector field mass spectrometry: advantages and limitations , 2000 .

[37]  F. Vanhaecke,et al.  Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP–mass spectrometry , 2004, Analytical and bioanalytical chemistry.

[38]  D. Smith,et al.  Lead isotopes as a supplementary tool in the routine evaluation of household lead hazards. , 2000, Environmental health perspectives.

[39]  M. Gerotto,et al.  Interference Effects and Their Control in ICP-MS Analysis of Serum and Saline Solutions , 1995 .

[40]  L. Font,et al.  Strontium and lead isotope ratios in human hair: investigating a potential tool for determining recent human geographical movements , 2012 .

[41]  F. Vanhaecke,et al.  Determination of isotope ratios of metals (and metalloids) by means of inductively coupled plasma-mass spectrometry for provenancing purposes — A review , 2010 .

[42]  P. Gallé,et al.  The Use of Secondary Ion Mass Spectrometry in Radiotoxicology , 1998 .

[43]  A. Rossmann,et al.  Isotope-abundance ratios of light (bio) and heavy (geo) elements in biogenic tissues: methods and applications , 2004, Analytical and bioanalytical chemistry.

[44]  Scott M Smith,et al.  Natural calcium isotopic composition of urine as a marker of bone mineral balance. , 2007, Clinical chemistry.

[45]  A. Wåhlin,et al.  Measurement of iron and zinc isotopes in human whole blood: preliminary application to the study of HFE genotypes. , 2005, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[46]  B. Öhlander,et al.  Separation of Fe from whole blood matrix for precise isotopic ratio measurements by MC-ICP-MS: a comparison of different approaches , 2003 .

[47]  B. Mcgaw,et al.  Determination of selected nickel isotopes in biological samples by inductively coupled plasma mass spectrometry with isotope dilution , 1996 .

[48]  W. Frech,et al.  Determination of methylmercury, ethylmercury, and inorganic mercury in mouse tissues, following administration of thimerosal, by species-specific isotope dilution GC-inductively coupled plasma-MS. , 2003, Analytical chemistry.

[49]  Brian Gulson,et al.  Stable Isotopic Tracing—A Way Forward for Nanotechnology , 2006, Environmental health perspectives.

[50]  T. Price,et al.  Megaliths and mobility in south-western Sweden. Investigating relationships between a local society and its neighbours using strontium isotopes , 2009 .

[51]  Ilia Rodushkin,et al.  Determination of 60 elements in whole blood by sector field inductively coupled plasma mass spectrometry , 2000 .

[52]  G. Stingeder,et al.  Strontium isotope ratio measurements in prehistoric human bone samples by means of high-resolution inductively coupled plasma mass spectrometry (HR-ICP-MS) , 1998 .

[53]  K. Heumann,et al.  Precision and accuracy in isotope ratio measurements by plasma source mass spectrometry , 1998 .

[54]  J. I. García-Alonso,et al.  Measurement of longitudinal sulfur isotopic variations by laser ablation MC-ICP-MS in single human hair strands , 2009, Analytical and bioanalytical chemistry.

[55]  R. Gwiazda,et al.  Improved lead isotope ratio measurements in environmental and biological samples with a double focussing magnetic sector inductively coupled plasma mass spectrometer (ICP-MS) , 1998 .

[56]  A. Sanz-Medel,et al.  Determination of cadmium in environmental and biological reference materials using isotope dilution analysis with a double focusing ICP-MS: a comparison with quadrupole ICP-MS , 1999 .

[57]  A. Jones,et al.  A normative value pilot study: levels of uranium in urine samples from UK civilians. , 2007, Environmental research.

[58]  I. Griffin.  Using stable isotopes and isotope ratio mass spectrometry to study mineral metabolism in humans: Invited lecture , 2002 .

[59]  D. Borrok,et al.  Zn and Cu isotopes as tracers of anthropogenic contamination in a sediment core from an urban lake. , 2010, Environmental science & technology.

[60]  K. Heumann.  Isotope-dilution ICP–MS for trace element determination and speciation: from a reference method to a routine method? , 2004, Analytical and bioanalytical chemistry.

[61]  P. Brown,et al.  Boron Determination—A Review of Analytical Methods , 1997 .

[62]  F. Albarède,et al.  Isotopic evidence of unaccounted for Fe and Cu erythropoietic pathways. , 2011, Metallomics : integrated biometal science.

[63]  J. Yoshinaga,et al.  Isotope Ratio Analysis of Lead in Blood and Environmental Samples by Multi-collector Inductively Coupled Plasma Mass Spectrometry , 2011, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[64]  A. Sanz-Medel,et al.  A comparison between quadrupole, double focusing and multicollector ICP-MS instruments. Part I. Evaluation of total combined uncertainty for lead isotope ratio measurements , 2001 .

[65]  David O. Carpenter,et al.  Depleted uranium contamination by inhalation exposure and its detection after ∼20 years: Implications for human health assessment , 2008 .

[66]  Donald R. Smith,et al.  A Noninvasive Isotopic Approach to Estimate the Bone Lead Contribution to Blood in Children: Implications for Assessing the Efficacy of Lead Abatement , 2004, Environmental health perspectives.

[67]  S. Boulyga.  Mass spectrometric analysis of long-lived radionuclides in bio-assays , 2011 .

[68]  A. Duraković.  The quantitative analysis of uranium isotopes in the urine of the civilian population of eastern Afghanistan after Operation Enduring Freedom. , 2005, Military medicine.

[69]  F. Blanckenburg,et al.  Deciphering the iron isotope message of the human body , 2005 .

[70]  R. Vocke,et al.  On the certification of cadmium at trace and ultratrace levels in standard reference materials using ID ICP-MS , 2007, Analytical and bioanalytical chemistry.

[71]  F. Albarède,et al.  Precise and accurate isotopic measurements using multiple-collector ICPMS 1 1 Associate editor: Y. Amelin , 2004 .

[72]  I. Hertz-Picciotto,et al.  Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study , 2011, Environmental health : a global access science source.

[73]  B. Sharp,et al.  An ICP-MS methodology using a combined high-resolution/multi-collector detector system for the measurement of total zinc and zinc isotope ratios in faecal samples from a human nutrition study , 2002 .

[74]  K. Murphy,et al.  The determination of lead in blood using isotope dilution inductively coupled plasma mass spectrometry , 1995 .

[75]  G. Alexander,et al.  Stable isotopes of lithium: in vivo differential distribution between plasma and cerebrospinal fluid. , 1982, Biological psychiatry.

[76]  I. Rodushkin,et al.  Methylmercury measurement in whole blood by isotope-dilution GC-ICPMS with 2 sample preparation methods. , 2007, Clinical chemistry.

[77]  Z. Mester,et al.  Paradigms in isotope dilution mass spectrometry for elemental speciation analysis. , 2008, Analytica chimica acta.

[78]  M. S. Epstein,et al.  Definitive measurement methods , 1991 .

[79]  L. Menichetti,et al.  Capillary electrophoresis–electrospray mass spectrometry and HR–ICP–MS for the detection and quantification of 10B-boronophenylalanine (10B–BPA) used in boron neutron capture therapy , 2006, Analytical and bioanalytical chemistry.

[80]  P. Behra,et al.  Hg speciation and stable isotope signatures in human hair as a tracer for dietary and occupational exposure to mercury. , 2011, Environmental science & technology.

[81]  Anu W. Turunen,et al.  Blood concentration of methylmercury in relation to food consumption , 2010, Public Health Nutrition.

[82]  P. Schramel,et al.  Thorium and uranium contents in human urine: influence of age and residential area. , 2004, Journal of environmental radioactivity.

[83]  Phil Jones,et al.  Determination of actinide elements at femtogram per gram levels in environmental samples by on-line solid phase extraction and sector-field-inductively coupled plasma-mass spectrometry , 2001 .

[84]  R. Barnes,et al.  Design concepts for strip-line microwave spectrochemical sources , 1990 .

[85]  F. Albarède,et al.  Fe and Cu stable isotopes in archeological human bones and their relationship to sex. , 2012, American journal of physical anthropology.

[86]  M. Rabinowitz.  Stable isotopes of lead for source identification. , 1995, Journal of toxicology. Clinical toxicology.

[87]  H. Delves,et al.  Accurate and precise determination of lead isotope ratios in clinical and environmental samples using inductively coupled plasma source mass spectrometry , 1989 .

[88]  I. Rodushkin,et al.  Serum/plasma methylmercury determination by isotope dilution gas chromatography-inductively coupled plasma mass spectrometry. , 2011, Analytica chimica acta.

[89]  David J D Carter,et al.  Precise and traceable (13)C/(12)C isotope amount ratios by multicollector ICPMS. , 2008, Analytical chemistry.

[90]  P. Rodríguez-González,et al.  Recent advances in isotope dilution analysis for elemental speciation , 2010 .

[91]  S. Caudill,et al.  Determination of uranium-235, uranium-238 and thorium-232 in urine by magnetic sector inductively coupled plasma mass spectrometry , 2002 .

[92]  L. Moens,et al.  Spectral interferences encountered in the analysis of biological materials by inductively coupled plasma mass spectrometry , 1994 .

[93]  T. Walczyk,et al.  Hereditary hemochromatosis is reflected in the iron isotope composition of blood. , 2005, Blood.

[94]  Celine Sutherland,et al.  The identification of lead ammunition as a source of lead exposure in First Nations: the use of lead isotope ratios. , 2008, The Science of the total environment.

[95]  D. Paschal,et al.  Rapid analysis for plutonium-239 in 1 ml of urine by magnetic sector inductively coupled plasma mass spectrometry with a desolvating introduction system , 2004 .

[96]  C. You,et al.  How well do non-traditional stable isotope results compare between different laboratories: results from the interlaboratory comparison of boron isotope measurements , 2009 .

[97]  C. Douthitt.  The evolution and applications of multicollector ICPMS (MC-ICPMS) , 2008, Analytical and bioanalytical chemistry.

[98]  A. Hirner,et al.  Comparative determination of methyl mercury in whole blood samples using GC-ICP-MS and GC-MS techniques. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[99]  E. Paredes,et al.  Isotope ratio measurements by MC-ICPMS below 10 μL min-1 under continuous sample flow conditions. Exploring the limits with strontium , 2013 .

[100]  G. Stingeder,et al.  Investigation of Sr isotope ratios in prehistoric human bones and teeth using laser ablation ICP-MS and ICP-MS after Rb/Sr separation , 2002 .

[101]  I. T. Platzner,et al.  Modern Isotope Ratio Mass Spectrometry , 1997 .

[102]  G. Turk,et al.  Comparison of clinical methods with isotope dilution inductively coupled plasma mass spectrometry for the new standard reference material 955c lead in caprine blood , 2009 .

[103]  T. Decsi,et al.  Methods of assessment of zinc status in humans: a systematic review. , 2009, The American journal of clinical nutrition.

[104]  K. Al-Saad,et al.  Collision/Reaction Cell ICP-MS with Shielded Torch and Sector Field ICP-MS for the Simultaneous Determination of Selenium Isotopes in Biological Matrices , 2011, Biological Trace Element Research.

[105]  F. Vanhaecke,et al.  Validated measurements of the uranium isotopic signature in human urine samples using magnetic sector-field inductively coupled plasma mass spectrometry. , 2004, Environmental science & technology.

[106]  P. Krystek,et al.  Determination of uranium in urine – measurement of isotope ratios and quantification by use of inductively coupled plasma mass spectrometry , 2002, Analytical and bioanalytical chemistry.

[107]  M. Trenouth,et al.  Relative exposure of children to lead from dust and drinking water. , 1993, Archives of environmental health.

[108]  I. Rodushkin,et al.  Sources of mass bias and isotope ratio variation in multi-collector ICP-MS: optimization of instrumental parameters based on experimental observations , 2004 .

[109]  Alan J. Taylor,et al.  Changes in the lead isotopic composition of blood, diet and air in Australia over a decade: globalization and implications for future isotopic studies. , 2006, Environmental research.

[110]  I. Rodushkin,et al.  Application of double focusing sector field ICP-MS for multielemental characterization of human hair and nails. Part II. A study of the inhabitants of northern Sweden. , 2000, The Science of the total environment.

[111]  S. Wessely,et al.  Urinary isotopic analysis in the UK Armed Forces: no evidence of depleted uranium absorption in combat and other personnel in Iraq , 2007, Occupational and Environmental Medicine.

[112]  Robert C. Hutton,et al.  Evaluation of inductively coupled argon plasma mass spectrometry (ICP-MS) for simultaneous multi-element trace analysis in clinical chemistry , 1988 .

[113]  T. Linsinger,et al.  SI-traceable certification of the amount content of cadmium below the ng g–1 level in blood samples by isotope dilution ICP–MS applied as a primary method of measurement , 2001, Analytical and Bioanalytical Chemistry.

[114]  Asaf Duraković,et al.  Undiagnosed illnesses and radioactive warfare. , 2003, Croatian medical journal.

[115]  A. Büttner,et al.  Origin assignment of unidentified corpses by use of stable isotope ratios of light (bio-) and heavy (geo-) elements--a case report. , 2007, Forensic science international.

[116]  M. Chiba,et al.  Isotopic Analysis of Fe in Human Red Blood Cells by Multiple Collector-ICP-Mass Spectrometry , 2004, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[117]  S. Stürup.  Application of HR-ICP-MS for the simultaneous measurement of zinc isotope ratios and total zinc content in human samples , 2000 .

[118]  P. Galan,et al.  A double stable isotope technique for measuring iron absorption in infants , 1994, British Journal of Nutrition.

[119]  P. Ostapczuk,et al.  Determination of Pu in urine at ultratrace level by sector field inductively coupled plasma mass spectrometry , 2004 .

[120]  M. Dean,et al.  Unlocking evidence of early diet from tooth enamel , 2008, Proceedings of the National Academy of Sciences.

[121]  P. Brown,et al.  Isotope ratio determination in boron analysis , 2007, Biological Trace Element Research.

[122]  J. Graziano,et al.  Bioavailability of soilborne lead in adults, by stable isotope dilution. , 1998, Environmental health perspectives.

[123]  R. Barnes.  Childhood soil ingestion: how much dirt do kids eat? , 1990, Analytical Chemistry.

[124]  K. Pye.  Isotope and trace element analysis of human teeth and bones for forensic purposes , 2004, Geological Society, London, Special Publications.

[125]  F. Mellon,et al.  Stable isotope methods for studying nutrient mineral metabolism in humans. , 1997, Endeavour.

[126]  F. Vanhaecke,et al.  Capabilities of inductively coupled plasma mass spectrometry for the measurement of Fe isotope ratios , 2002 .

[127]  T. A. Brown,et al.  Ultra-sensitive Mass Spectrometric and Other Advanced Methods Applied to Biological Samples; Second interlaboratory comparison study for the analysis of 239Pu in synthetic urine at the µBq (~100 aCi) level by mass spectrometry , 2005 .

[128]  J. Turnlund,et al.  Determination of molybdenum and enriched Mo stable isotope concentrations in human blood plasma by isotope dilution ICP-MS , 2002 .

[129]  W. Lambert,et al.  Isotope-dilution mass spectrometry in clinical chemistry. , 1985, Advances in clinical chemistry.

[130]  U. Sansone,et al.  Determination of Pu isotope concentrations and isotope ratio by inductively coupled plasma mass spectrometry: a review of analytical methodology , 2007 .

[131]  S. Tanner,et al.  Reaction cells and collision cells for ICP-MS: a tutorial review , 2002 .

[132]  J. D. Fassett.  Isotopic and nuclear analytical techniques in biological systems: A critical study-X. Elemental isotope dilution analysis with radioactive and stable isotopes (Technical Report) , 1995 .

[133]  P. Froidevaux,et al.  Determining picogram quantities of uranium in urine by isotope dilution inductively coupled plasma mass spectrometry. Comparison with α-spectrometry , 2001 .

[134]  R. Barnes.  Advances in inductively coupled plasma mass spectrometry: human nutrition and toxicology , 1993 .

[135]  T. Walczyk,et al.  Natural Iron Isotope Variations in Human Blood , 2002, Science.

[136]  C. S. Allardyce,et al.  Determination of drug binding sites to proteins by electrospray ionisation mass spectrometry: the interaction of cisplatin with transferrin. , 2002, Rapid communications in mass spectrometry : RCM.

[137]  R. Houk,et al.  Fundamental aspects of ion extraction in inductively coupled plasma mass spectrometry , 1996 .

[138]  G. Vimpani,et al.  Identification of sources of lead in children in a primary zinc-lead smelter environment. , 2003, Environmental health perspectives.

[139]  I. Rodushkin,et al.  Isotopic analysis of the metabolically relevant transition metals Cu, Fe and Zn in human blood from vegetarians and omnivores using multi-collector ICP-mass spectrometry , 2012 .

[140]  D. Zmirou-Navier,et al.  Identification of sources of lead exposure in French children by lead isotope analysis: a cross-sectional study , 2011, Environmental health : a global access science source.

[141]  H. Delves,et al.  Measurements of total lead concentrations and of lead isotope ratios in whole blood by use of inductively coupled plasma source mass spectrometry , 1988 .

[142]  R. Fitzgerald,et al.  Mass spectrometry of trace elements in biological samples. , 1994, Critical reviews in clinical laboratory sciences.

[143]  J. D. Fassett,et al.  Isotope dilution mass spectrometry for accurate elemental analysis , 1989 .

[144]  J. Montgomery,et al.  A summary of strontium and oxygen isotope variation in archaeological human tooth enamel excavated from Britain , 2012 .

[145]  H. Noguchi,et al.  Development of rapid bioassay method for plutonium , 2002 .

[146]  A. Eisenhauer,et al.  A pilot study on the use of natural calcium isotope (44Ca/40Ca) fractionation in urine as a proxy for the human body calcium balance. , 2010, Bone.

[147]  J. P. Bramson,et al.  Actinide bioassays by ICPMS , 1998 .

[148]  D. Paschal,et al.  Rapid analysis for plutonium-239 in urine by magnetic sector inductively coupled plasma-mass spectrometry using Aridus desolvation introduction system , 2003 .

[149]  B. Gulson,et al.  The effect of exposure to employees from mining and milling operations in a uranium mine on lead isotopes--a pilot study. , 2005, The Science of the total environment.

[150]  D. Salvo,et al.  Validation of (68)Ge/(68)Ga generator processing by chemical purification for routine clinical application of (68)Ga-DOTATOC. , 2008, Nuclear medicine and biology.

[151]  C. Cossonnet,et al.  Potentialities of mass spectrometry (ICP-MS) for actinides determination in urine. , 2004, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[152]  A. Sanz-Medel,et al.  Isotope dilution analysis for elemental speciation: a tutorial review , 2005 .

[153]  B. Gulson,et al.  History of lead exposure in children revealed from isotopic analyses of teeth. , 1994, Archives of environmental health.

[154]  Rolf Gruetter,et al.  Hyperpolarized lithium‐6 as a sensor of nanomolar contrast agents , 2009, Magnetic resonance in medicine.

[155]  I. Rodushkin,et al.  Measuring 0.01‰ to 0.1‰ isotopic variations by MC-ICPMS—testing limits for the first time with Pb δ-iCRMs , 2009 .

[156]  R. D. Evans,et al.  Rapid determination of plutonium in urine using flow injection on-line preconcentration and inductively coupled plasma mass spectrometry , 2005 .

[157]  L. Hooper,et al.  Methods of assessment of selenium status in humans: a systematic review. , 2009, The American journal of clinical nutrition.

[158]  A. Sanz-Medel,et al.  Quantitative speciation of selenium in human serum by affinity chromatography coupled to post-column isotope dilution analysis ICP-MS , 2003 .