Characterization of a mammographic system based on single photon counting pixel arrays coupled to GaAs x-ray detectors.

The authors report on the imaging capabilities of a mammographic system demonstrator based on GaAs pixel detectors operating in single photon counting (SPC) mode. The system imaging performances have been assessed by means of the transfer functions: The modulation transfer function (MTF), the normalized noise power spectrum, and the detective quantum efficiency (DQE) have been measured following the guidelines of the IEC 62220-1-2 protocol. The transfer function analysis has shown the high spatial resolution capabilities of the GaAs detectors. The MTF calculated at the Nyquist frequency (2.94 cycles/mm) is indeed 60%. The DQE, measured with a standard mammographic beam setup (Mo/Mo, 28 kVp, with 4 mm Al added filter) and calculated at zero frequency, is 46%. Aiming to further improve the system's image quality, the authors investigate the DQE limiting factors and show that they are mainly related to system engineering. For example, the authors show that optimization of the image equalization procedure increases the DQE(0) up to 74%, which is better than the DQE(0) of most clinical mammographic systems. The authors show how the high detection efficiency of GaAs detectors and the noise discrimination associated with the SPC technology allow optimizing the image quality in mammography. In conclusion, the authors propose technological solutions to exploit to the utmost the potentiality of GaAs detectors coupled to SPC electronics.

[1]  W. Rugh Linear System Theory , 1992 .

[2]  Björn Cederström,et al.  Physical characterization of a scanning photon counting digital mammography system based on Si-strip detectors. , 2007, Medical physics.

[3]  Piernicola Oliva,et al.  Experimental study of Compton scattering reduction in digital mammographic imaging , 2001 .

[4]  M. G. Bisogni,et al.  An example of technological transfer to industry: the “IMI” project , 2004 .

[5]  N W Marshall,et al.  Early experience in the use of quantitative image quality measurements for the quality assurance of full field digital mammography x-ray systems , 2007, Physics in medicine and biology.

[6]  A. Cetronio,et al.  Interconnection techniques of GaAs pixel detector on silicon ASIC electronics , 2004, IEEE Symposium Conference Record Nuclear Science 2004..

[7]  C. D'Orsi,et al.  Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening , 2006 .

[8]  C. D'Orsi,et al.  Diagnostic Performance of Digital Versus Film Mammography for Breast-Cancer Screening , 2005, The New England journal of medicine.

[9]  Karl Jakobs,et al.  Medipix2: Processing and measurements of GaAs pixel detectors , 2007 .

[10]  Walter Snoeys,et al.  Performance of a 4096-pixel photon counting chip , 1998, Optics & Photonics.

[11]  H. Nilsson,et al.  Simulation of photon and charge transport in X-ray imaging semiconductor sensors , 2002 .

[12]  James T. Dobbins Image Quality Metrics for Digital Systems , 2000 .

[13]  S. Evans Catalogue of Diagnostic X-Ray Spectra and Other Data , 1998 .

[14]  M. G. Bisogni,et al.  Low contrast imaging with a GaAs pixel digital detector , 1999, 1999 IEEE Nuclear Science Symposium. Conference Record. 1999 Nuclear Science Symposium and Medical Imaging Conference (Cat. No.99CH37019).

[15]  H. Nilsson,et al.  Spectral response of pixellated semiconductor X-ray detectors , 2005, IEEE Nuclear Science Symposium Conference Record, 2005.

[16]  M. G. Bisogni,et al.  Semiconductor pixel detectors for digital mammography , 2003 .

[17]  Thomas Oshiro,et al.  Evaluation of detector dynamic range in the x-ray exposure domain in mammography: a comparison between film-screen and flat panel detector systems. , 2003, Medical physics.

[18]  Giuseppe Bertuccio,et al.  Prospect for energy resolving X-ray imaging with compound semiconductor pixel detectors , 2005 .

[19]  GaAs detectors — A review , 1997 .

[20]  Ulrich Neitzel,et al.  Accuracy of a simple method for deriving the presampled modulation transfer function of a digital radiographic system from an edge image. , 2003, Medical physics.

[21]  H.-E. Nilsson,et al.  Monte Carlo simulation of charge sharing effects in silicon and GaAs photon-counting X-ray imaging detectors , 2004, IEEE Transactions on Nuclear Science.

[22]  M. Campbell,et al.  The Medipix3 Prototype, a Pixel Readout Chip Working in Single Photon Counting Mode With Improved Spectrometric Performance , 2006, IEEE Transactions on Nuclear Science.

[23]  E. Samei,et al.  A method for measuring the presampled MTF of digital radiographic systems using an edge test device. , 1998, Medical physics.

[24]  R. Dinapoli,et al.  Medipix2: A 64-k pixel readout chip with 55-/spl mu/m square elements working in single photon counting mode , 2001 .

[25]  F R Verdun,et al.  A comparison of the performance of digital mammography systems. , 2007, Medical physics.

[26]  Claudio Lanzieri,et al.  A GaAs pixel detectors-based digital mammographic system: Performances and imaging tests results , 2007 .

[27]  Ehsan Samei,et al.  Determination of the detective quantum efficiency of a digital x-ray detector: comparison of three evaluations using a common image data set. , 2004, Medical physics.

[28]  Franz Kainberger,et al.  Dear-Mama: A photon counting X-ray imaging project for medical applications , 2006 .

[29]  G Belli,et al.  Physical characteristics of five clinical systems for digital mammography. , 2007, Medical physics.