Sildenafil ameliorates EAE by decreasing apoptosis in the spinal cord of C57BL/6 mice

[1]  H. Yamamura,et al.  Tadalafil induces antiproliferation, apoptosis, and phosphodiesterase type 5 downregulation in idiopathic pulmonary arterial hypertension in vitro , 2017, European journal of pharmacology.

[2]  Agustina Garcı́a,et al.  Mechanisms Involved in the Remyelinating Effect of Sildenafil , 2017, Journal of Neuroimmune Pharmacology.

[3]  V. Yong,et al.  Remyelination therapies: a new direction and challenge in multiple sclerosis , 2017, Nature Reviews Drug Discovery.

[4]  S. A. Eltony,et al.  Effect of chronic administration of sildenafil citrate (Viagra) on the histology of the retina and optic nerve of adult male rat. , 2017, Tissue & cell.

[5]  Sally E Abu-Risha,et al.  Combination of tadalafil and diltiazem attenuates renal ischemia reperfusion-induced acute renal failure in rats. , 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[6]  M. El-Naa,et al.  Sildenafil potentiates the antitumor activity of cisplatin by induction of apoptosis and inhibition of proliferation and angiogenesis , 2016, Drug design, development and therapy.

[7]  M. R. França,et al.  Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice , 2016, Brain Research.

[8]  F. Tovar-Moll,et al.  Phosphodiesterase-5 inhibition promotes remyelination by MCP-1/CCR-2 and MMP-9 regulation in a cuprizone-induced demyelination model , 2016, Experimental Neurology.

[9]  Justin M Honce,et al.  Remyelination Therapy in Multiple Sclerosis , 2015, Front. Neurol..

[10]  D. Centonze,et al.  Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis , 2015, Nature Reviews Neurology.

[11]  C. Rapôso,et al.  Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model , 2015, Brain Research.

[12]  Yong Li,et al.  Sildenafil inhibits the growth of human colorectal cancer in vitro and in vivo. , 2015, American journal of cancer research.

[13]  A. Harraz,et al.  Sildenafil activates antioxidant and antiapoptotic genes and inhibits proinflammatory cytokine genes in a rat model of renal ischemia/reperfusion injury , 2015, International Urology and Nephrology.

[14]  Guoxing Wang,et al.  The effects of phosphodiesterase-5 inhibitor sildenafil against post-resuscitation myocardial and intestinal microcirculatory dysfunction by attenuating apoptosis and regulating microRNAs expression: essential role of nitric oxide syntheses signaling , 2015, Journal of Translational Medicine.

[15]  M. Diamond,et al.  Sildenafil Prevents Apoptosis of Human First-Trimester Trophoblast Cells Exposed to Oxidative Stress , 2015, Reproductive Sciences.

[16]  N. Durán,et al.  Violacein Treatment Modulates Acute and Chronic Inflammation through the Suppression of Cytokine Production and Induction of Regulatory T Cells , 2015, PloS one.

[17]  Wenwei Liu,et al.  Kirenol Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Differentiation of Th1 and Th17 Cells and Inducing Apoptosis of Effector T Cells , 2015, Scientific Reports.

[18]  M. Nagarkatti,et al.  3,3′-Diindolylmethane Ameliorates Experimental Autoimmune Encephalomyelitis by Promoting Cell Cycle Arrest and Apoptosis in Activated T Cells through MicroRNA Signaling Pathways , 2014, The Journal of Pharmacology and Experimental Therapeutics.

[19]  B. Tackenberg,et al.  MK2 and Fas Receptor Contribute to the Severity of CNS Demyelination , 2014, PloS one.

[20]  A. Komaki,et al.  Differential Effects of Sildenafil (Viagra) on Processing Steps of Spatial Learning and Memory in Rat , 2014 .

[21]  C. Rapôso,et al.  Role of iNOS-NO-cGMP signaling in modulation of inflammatory and myelination processes , 2014, Brain Research Bulletin.

[22]  A. Palmeri,et al.  Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice , 2014, Neurobiology of Aging.

[23]  Agustina Garcı́a,et al.  Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions , 2014, Experimental Neurology.

[24]  Peter E. Czabotar,et al.  Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy , 2013, Nature Reviews Molecular Cell Biology.

[25]  M. Prinz,et al.  Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology. , 2013, Trends in molecular medicine.

[26]  C. Teuscher,et al.  The Emerging Role of p38 Mitogen-Activated Protein Kinase in Multiple Sclerosis and Its Models , 2013, Molecular and Cellular Biology.

[27]  C. Rapôso,et al.  Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model , 2013, Mediators of inflammation.

[28]  N. Perrone-Bizzozero,et al.  Increased carbonylation, protein aggregation and apoptosis in the spinal cord of mice with experimental autoimmune encephalomyelitis , 2013, ASN neuro.

[29]  L. Soane,et al.  Multiple functions of BCL-2 family proteins. , 2013, Cold Spring Harbor perspectives in biology.

[30]  Xu Wang,et al.  Astrocytic Fas ligand expression is required to induce T‐cell apoptosis and recovery from experimental autoimmune encephalomyelitis , 2013, European journal of immunology.

[31]  Bin Wang,et al.  Treg Cell Resistance to Apoptosis in DNA Vaccination for Experimental Autoimmune Encephalomyelitis Treatment , 2012, PloS one.

[32]  A. Nunes,et al.  Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model. , 2012, Cytokine.

[33]  M. Chopp,et al.  Sildenafil Enhances Neurogenesis and Oligodendrogenesis in Ischemic Brain of Middle-Aged Mouse , 2012, PloS one.

[34]  Robert H Miller,et al.  Apoptosis of oligodendrocytes in the central nervous system results in rapid focal demyelination , 2012, Annals of neurology.

[35]  A. Fukamizu,et al.  Mechanism for p38α-mediated Experimental Autoimmune Encephalomyelitis* , 2012, The Journal of Biological Chemistry.

[36]  O. Bizzozero,et al.  Protein carbonylation and aggregation precede neuronal apoptosis induced by partial glutathione depletion , 2012, ASN neuro.

[37]  Michael Chopp,et al.  Longitudinal Magnetic Resonance Imaging of Sildenafil Treatment of Embolic Stroke in Aged Rats , 2011, Stroke.

[38]  R. Franco,et al.  Sildenafil restores cognitive function without affecting β‐amyloid burden in a mouse model of Alzheimer's disease , 2011, British journal of pharmacology.

[39]  M. Wong,et al.  cGMP Signaling, Phosphodiesterases and Major Depressive Disorder , 2011, Current neuropharmacology.

[40]  J. Ashwell,et al.  Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation. , 2011, Blood.

[41]  C. Teuscher,et al.  Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. , 2011, Blood.

[42]  Jie Zhu,et al.  Kainic Acid-Induced Neurotoxicity: Targeting Glial Responses and Glia-Derived Cytokines , 2011, Current neuropharmacology.

[43]  Istvan Pirko,et al.  The relevance of animal models in multiple sclerosis research. , 2011, Pathophysiology : the official journal of the International Society for Pathophysiology.

[44]  Agustina Garcı́a,et al.  Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis , 2011, Acta Neuropathologica.

[45]  S. Burchill,et al.  p38(MAPK): stress responses from molecular mechanisms to therapeutics. , 2009, Trends in molecular medicine.

[46]  M. Rincón,et al.  Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival , 2008, International journal of biological sciences.

[47]  D. Ginsberg,et al.  E2F - at the crossroads of life and death. , 2008, Trends in cell biology.

[48]  M. Guazzi,et al.  Phosphodiesterase-5 Inhibition Abolishes Neuron Apoptosis Induced by Chronic Hypoxia Independently of Hypoxia-Inducible Factor-1α Signaling , 2008, Experimental biology and medicine.

[49]  N. Banik,et al.  Activation of calpain and caspase pathways in demyelination and neurodegeneration in animal model of multiple sclerosis. , 2008, CNS & neurological disorders drug targets.

[50]  Michael Chopp,et al.  Magnetic Resonance Imaging Investigation of Axonal Remodeling and Angiogenesis after Embolic Stroke in Sildenafil-Treated Rats , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[51]  G. Robertson,et al.  Targeting apoptosis to treat multiple sclerosis. , 2008, Current drug discovery technologies.

[52]  E. Wagner,et al.  p38α: A Suppressor of Cell Proliferation and Tumorigenesis , 2007 .

[53]  Neeta Singh.  Apoptosis in health and disease and modulation of apoptosis for therapy: An overview , 2007, Indian Journal of Clinical Biochemistry.

[54]  Jinghong Chen,et al.  Apoptosis induced by NO via phosphorylation of p38 MAPK that stimulates NF‐κB, p53 and caspase‐3 activation in rabbit articular chondrocytes , 2007, Cell biology international.

[55]  Azad Bonni,et al.  p38 MAP Kinase Mediates Apoptosis through Phosphorylation of BimEL at Ser-65* , 2006, Journal of Biological Chemistry.

[56]  S. Radhakrishnan,et al.  Pro-apoptotic role of NF-κB: Implications for cancer therapy , 2006 .

[57]  Lawrence Steinman,et al.  How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis , 2006, Annals of neurology.

[58]  L. Steinman,et al.  Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis. , 2005, Trends in immunology.

[59]  G. Kollias,et al.  Apoptosis of Oligodendrocytes via Fas and TNF-R1 Is a Key Event in the Induction of Experimental Autoimmune Encephalomyelitis1 , 2005, The Journal of Immunology.

[60]  B. Hilliard,et al.  Essential Roles of the Fas-Associated Death Domain in Autoimmune Encephalomyelitis1 , 2005, The Journal of Immunology.

[61]  P. Fisher,et al.  Phosphodiesterase-5 Inhibition With Sildenafil Attenuates Cardiomyocyte Apoptosis and Left Ventricular Dysfunction in a Chronic Model of Doxorubicin Cardiotoxicity , 2005, Circulation.

[62]  Anindita Das,et al.  Phosphodiesterase-5 Inhibitor Sildenafil Preconditions Adult Cardiac Myocytes against Necrosis and Apoptosis , 2005, Journal of Biological Chemistry.

[63]  J. Strosznajder,et al.  Cyclic GMP metabolism and its role in brain physiology. , 2005, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[64]  J. Corbin,et al.  Mechanisms of action of PDE5 inhibition in erectile dysfunction , 2004, International Journal of Impotence Research.

[65]  Teiji Wada,et al.  Mitogen-activated protein kinases in apoptosis regulation , 2004, Oncogene.

[66]  J. Epstein,et al.  Novel and Detrimental Effects of Lipopolysaccharide on In Vitro Generation of Immature Dendritic Cells: Involvement of Mitogen-Activated Protein Kinase p38 1 , 2003, The Journal of Immunology.

[67]  K. Iwabuchi,et al.  Differential role of mitogen-activated protein kinases in CD40-mediated IL-12 production by immature and mature dendritic cells. , 2003, Immunology letters.

[68]  Y. Jee,et al.  Activation of mitogen-activated protein kinases in experimental autoimmune encephalomyelitis , 2003, Journal of Neuroimmunology.

[69]  F. Kiechle,et al.  Apoptosis: biochemical aspects and clinical implications. , 2002, Clinica chimica acta; international journal of clinical chemistry.

[70]  Jorge R. Oksenberg,et al.  Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis , 2002, Nature Medicine.

[71]  L. Shekerdemian,et al.  Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension. , 2002, American journal of respiratory and critical care medicine.

[72]  Michael Karin,et al.  NF-κB at the crossroads of life and death , 2002, Nature Immunology.

[73]  R. Ientile,et al.  Apoptosis and necrosis occurring in excitotoxic cell death in isolated chick embryo retina , 2001, Journal of neurochemistry.

[74]  M. Bahr,et al.  Acute Neuronal Apoptosis in a Rat Model of Multiple Sclerosis , 2001, The Journal of Neuroscience.

[75]  Y. Barde,et al.  Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. , 2000, Genes & development.

[76]  T. Gilmore,et al.  Control of apoptosis by Rel/NF-κB transcription factors , 1999, Oncogene.

[77]  J. Corbin,et al.  Cyclic GMP Phosphodiesterase-5: Target of Sildenafil* , 1999, The Journal of Biological Chemistry.

[78]  I. Goldstein,et al.  Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. , 1998, The New England journal of medicine.

[79]  D. Goeddel,et al.  The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation , 1995, Cell.

[80]  M. Pender,et al.  Macrophage apoptosis in the central nervous system in experimental autoimmune encephalomyelitis. , 1994, Journal of autoimmunity.

[81]  N. Hellings,et al.  Which immune cells matter? The immunopathogenesis of multiple sclerosis. , 2013, Critical reviews in immunology.

[82]  J. Beavo,et al.  Cyclic nucleotides and phosphodiesterases in monocytic differentiation. , 2011, Handbook of experimental pharmacology.

[83]  S. Radhakrishnan,et al.  Pro-apoptotic role of NF-kappaB: implications for cancer therapy. , 2006, Biochimica et biophysica acta.

[84]  P. Scheurich,et al.  Tumor necrosis factor signaling , 2003, Cell Death and Differentiation.