Comparison of Intensity-and Jacobian-Based Estimates of Lung Regional Ventilation

Regional ventilation is the measurement of pulmonary function on a local, or regional level. The measurement of pulmonary function may be useful as a planning tool during radiation therapy (RT) planning, may be useful for tracking the progression of toxicity to nearby normal tissue during RT and can be used to evaluate the effectiveness of a treatment post-therapy. In this paper, we show that an intensity-based regional ventilation measure can be derived from a Jacobian-based measure by relaxing the assumption that there is no tissue volume change. We compare intensity-based and Jacobian-based measures of regional ventilation to xenon-CT (Xe-CT) measures of specific ventilation. The results show that the Jacobian-based measure correlates better (average r = 0.80) with Xe-CT-based measures of specific ventilation than the intensity-based measure (average r = 0.54). The difference between the intensity-based measure and the Jacobian-based measure of regional ventilation is linearly related to the tissue volume difference between scans (average r = 0.86).

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