Reduced Variance in the latency and Amplitude of the Fifth Wave of Auditory Brain Stem Response after Normalization for Head Size

Abstract The value of the Auditory Brain Stem Response (ABR] in the assessment and detection of neurological disorders could be considerably enhanced if the normative standards of ABR characteristic parameters take into account all other systematic sources of Variance. The present study attempts to take into account the influence of head size on latency and amplitude of the ABR componants. We examined amplitude and latency as a function of head size in 40 normal male subjects (age 20-40 years]. Significant negative correlation was found between amplitude and head radius. The experimental data were fitted using a theoretical curve of the potential on the surface of a three concentric sphere model representing the human head. The fitted curve of amplitude versus radius can be applied to normative data in order to substantially reduce dispersion and consequently increase the diagnostic value of this parameter. Moreover, a substantial effect of radius on wave V latency was detected. Normalization of the latencies with reference to the head radius, assuming that the latter is proportional to the length of brain stem, resulted in a significant reduction in the standard deviation of these data as compared to the original.

[1]  O Bertrand,et al.  A theoretical justification of the average reference in topographic evoked potential studies. , 1985, Electroencephalography and clinical neurophysiology.

[2]  J. Durrant,et al.  On the origin of wave II of the auditory brain stem evoked response. , 1991, Ear and hearing.

[3]  D. A. Driscoll,et al.  EEG electrode sensitivity--an application of reciprocity. , 1969, IEEE transactions on bio-medical engineering.

[4]  F. Musiek,et al.  Current concepts on the use of ABR and auditory psychophysical tests in the evaluation of brain stem lesions. , 1988, The American journal of otology.

[5]  K Schmidt-Nielsen,et al.  Scaling in biology: the consequences of size. , 1975, The Journal of experimental zoology.

[6]  P. Nunez,et al.  Electric fields of the brain , 1981 .

[7]  J Jerger,et al.  Analysis of gender differences in the auditory brainstem response , 1990, The Laryngoscope.

[8]  M Scherg,et al.  A new interpretation of the generators of BAEP waves I-V: results of a spatio-temporal dipole model. , 1985, Electroencephalography and clinical neurophysiology.

[9]  D. Trune,et al.  Variables affecting the auditory brainstem response: Audiogram, age, gender and head size , 1989, Hearing Research.

[10]  T A Sears,et al.  The effects of experimental demyelination on conduction in the central nervous system. , 1970, Brain : a journal of neurology.

[11]  A. Starr,et al.  Correlation between confirmed sites of neurological lesions and abnormalities of far-field auditory brainstem responses. , 1976, Electroencephalography and clinical neurophysiology.

[12]  A. Møller,et al.  Contributions from the auditory nerve to the brain-stem auditory evoked potentials (BAEPs): results of intracranial recording in man. , 1988, Electroencephalography and clinical neurophysiology.

[13]  Y. Koike,et al.  Head size as a basis of gender difference in the latency of the brainstem auditory-evoked response. , 1990, Audiology : official organ of the International Society of Audiology.

[14]  J J Eggermont,et al.  Narrow-band AP latencies in normal and recruiting human ears. , 1979, The Journal of the Acoustical Society of America.

[15]  C C Wood,et al.  Brain stem auditory, pattern-reversal visual, and short-latency somatosensory evoked potentials: latencies in relation to age, sex, and brain and body size. , 1983, Electroencephalography and clinical neurophysiology.

[16]  D L Jewett,et al.  The effect of media inhomogeneities upon intracranial electrical fields. , 1972, IEEE transactions on bio-medical engineering.

[17]  R. Burkard,et al.  DEVELOPMENTAL DEPENDENCIES OF THE HUMAN BRAINSTEM AUDITORY EVOKED RESPONSE , 1980, Annals of the New York Academy of Sciences.

[18]  A. Møller,et al.  Intracranially recorded responses from the human auditory nerve: new insights into the origin of brain stem evoked potentials (BSEPs). , 1981, Electroencephalography and clinical neurophysiology.

[19]  Auditory evoked potentials recorded directly from the human VIIIth nerve and brain stem: origins of their fast and slow components. , 1982, Electroencephalography and clinical neurophysiology. Supplement.

[20]  M. Igarashi,et al.  Transection of crossed olivo-cochlear bundle and auditory brain stem responses in the cat. , 1982, Acta oto-laryngologica.

[21]  J. P. Ary,et al.  Location of Sources of Evoked Scalp Potentials: Corrections for Skull and Scalp Thicknesses , 1981, IEEE Transactions on Biomedical Engineering.

[22]  J. Stockard,et al.  Brainstem auditory-evoked responses. Normal variation as a function of stimulus and subject characteristics. , 1979, Archives of neurology.

[23]  M Schneider.  Effect of inhomogeneities on surface signals coming from a cerebral current-dipole source. , 1974, IEEE transactions on bio-medical engineering.

[24]  M. Mazor,et al.  Relationship between head size and latency of the auditory brainstem response. , 1986, Audiology : official organ of the International Society of Audiology.

[25]  A. Starr,et al.  Auditory brain stem responses in the cat. II. Effects of lesions. , 1980, Electroencephalography and clinical neurophysiology.

[26]  D. Trune,et al.  The relative importance of head size, gender and age on the auditory brainstem response , 1988, Hearing Research.

[27]  M. Matthies,et al.  Correlations between various measures of head size and auditory brainstem response latencies , 1989, Hearing Research.

[28]  N. Galloway,et al.  Evoked Potentials , 1987 .