Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice
暂无分享,去创建一个
M. Ascano | T. Tuschl | D. Patel | K. Rothamel | Rei Okamoto | C. Adura | J. F. Glickman | T. Imaeda | T. Gogakos | P. Gao | K. Aso | J. Vincent | S. Reasoner | L. Lama | A. Luz | Y. Asano | J. Steinberg | J. Aida
[1] I. Haga,et al. IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes , 2017, Nature Communications.
[2] S. Paludan,et al. Viral evasion of DNA-stimulated innate immune responses , 2016, Cellular & Molecular Immunology.
[3] Jared E. Toettcher,et al. Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection , 2016, mBio.
[4] D. Pisetsky. Anti-DNA antibodies — quintessential biomarkers of SLE , 2016, Nature Reviews Rheumatology.
[5] K. Elkon,et al. Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity. , 2016, Annual review of medicine.
[6] Elizabeth E Gray,et al. DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway , 2015, Science.
[7] Zhijian J. Chen,et al. Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases , 2015, Proceedings of the National Academy of Sciences.
[8] Elizabeth E Gray,et al. Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome , 2015, The Journal of Immunology.
[9] Zhigang Zhang,et al. Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses , 2015, Proceedings of the National Academy of Sciences.
[10] Charles M. Rice,et al. Corrigendum: A diverse range of gene products are effectors of the type I interferon antiviral response , 2015, Nature.
[11] Jonathan L. Schmid-Burgk,et al. Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1. , 2015, Cell host & microbe.
[12] H. Virgin,et al. The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy. , 2015, Cell host & microbe.
[13] Zhijian J. Chen,et al. Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis. , 2015, Cell host & microbe.
[14] A. Bowie,et al. Innate immune recognition of DNA: A recent history. , 2015, Virology.
[15] J. An,et al. Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase–DNA Interaction , 2015, The Journal of Immunology.
[16] D. C. Hancks,et al. cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection , 2015, Proceedings of the National Academy of Sciences.
[17] R. Means,et al. Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response , 2014, Nature.
[18] Matthew E. Ritchie,et al. Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production , 2014, Cell.
[19] G. Barber,et al. Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING , 2014, The Journal of Immunology.
[20] V. Lupashin,et al. The DNA Sensor, Cyclic GMP–AMP Synthase, Is Essential for Induction of IFN-β during Chlamydia trachomatis Infection , 2014, The Journal of Immunology.
[21] T. Decker,et al. Listeria monocytogenes induces IFNβ expression through an IFI16‐, cGAS‐ and STING‐dependent pathway , 2014, The EMBO journal.
[22] V. Hornung,et al. OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids , 2014, Nature Reviews Immunology.
[23] Zhijian J. Chen,et al. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. , 2014, Molecular cell.
[24] Zhijian J. Chen,et al. Innate immune sensing and signaling of cytosolic nucleic acids. , 2014, Annual review of immunology.
[25] K. Fitzgerald,et al. Recognition of cytosolic DNA by cGAS and other STING‐dependent sensors , 2014, European journal of immunology.
[26] Zhijian J. Chen,et al. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. , 2014, Cell reports.
[27] Zhijian J. Chen,et al. Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects , 2013, Science.
[28] Nan Yan,et al. Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses , 2013, Science.
[29] Roger A. Jones,et al. Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA , 2013, Cell.
[30] Andrew S. Kohlway,et al. Defining the functional determinants for RNA surveillance by RIG-I , 2013, EMBO reports.
[31] Zhijian J. Chen,et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. , 2013, Molecules and Cells.
[32] V. Hornung,et al. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING , 2013, Nature.
[33] R. Vance,et al. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. , 2013, Cell reports.
[34] V. Hornung,et al. Structural mechanism of cytosolic DNA sensing by cGAS , 2013, Nature.
[35] A. Bowie,et al. Immune sensing of DNA. , 2013, Immunity.
[36] Roger A. Jones,et al. Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase , 2013, Cell.
[37] Zhijian J. Chen,et al. Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway , 2013, Science.
[38] Zhijian J. Chen,et al. Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA , 2013, Science.
[39] R. Vance,et al. STING and the innate immune response to nucleic acids in the cytosol , 2012, Nature Immunology.
[40] John H Livingston,et al. Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature , 2012, Nature Genetics.
[41] R. Naumann,et al. Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity , 2012, The Journal of experimental medicine.
[42] Martin A. M. Reijns,et al. Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development , 2012, Cell.
[43] Sarah E. Ewald,et al. Nucleic acid recognition by the innate immune system. , 2011, Annual review of immunology.
[44] A. Bowie,et al. IFI16 is an innate immune sensor for intracellular DNA , 2010, Nature Immunology.
[45] Y. Blat. Non‐Competitive Inhibition by Active Site Binders , 2010, Chemical biology & drug design.
[46] P. Emsley,et al. Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.
[47] J. Baell,et al. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. , 2010, Journal of medicinal chemistry.
[48] Randy J. Read,et al. Acta Crystallographica Section D Biological , 2003 .
[49] G. Barber,et al. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity , 2009, Nature.
[50] Xiaoping Zhou,et al. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization , 2009, Proceedings of the National Academy of Sciences.
[51] G. Barber,et al. STING an Endoplasmic Reticulum Adaptor that Facilitates Innate Immune Signaling , 2008, Nature.
[52] Y. Li,et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. , 2008, Immunity.
[53] T. Heidmann,et al. Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity , 2008, Cell.
[54] Randy J. Read,et al. Phaser crystallographic software , 2007, Journal of applied crystallography.
[55] Gabriela Chiosis,et al. High-Throughput Screening Fluorescence Polarization Assay for Tumor-Specific Hsp90 , 2007, Journal of biomolecular screening.
[56] D. Barnes,et al. Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome. , 2007, American journal of human genetics.
[57] D. Barnes,et al. Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus , 2006, Nature Genetics.
[58] D. Barnes,et al. Gene-Targeted Mice Lacking the Trex1 (DNase III) 3′→5′ DNA Exonuclease Develop Inflammatory Myocarditis , 2004, Molecular and Cellular Biology.
[59] Thomas D. Y. Chung,et al. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.
[60] E. Borowski,et al. The geometry of intercalation complex of antitumor mitoxantrone and ametantrone with DNA: molecular dynamics simulations. , 1998, Acta biochimica Polonica.
[61] B. Tidor. Molecular dynamics simulations , 1997, Current Biology.
[62] H. Gutfreund,et al. Enzyme kinetics , 1975, Nature.