Hypercalcemia complicating childhood malignancies. A report of seven cases with some pathophysiological considerations

A group of seven children with different malignant processes presenting with hypercalcemia was studied. Bone destruction, diffuse metabolic abnormalities, abnormal acid‐base homeostasis and recurrent hypercalcemia characterized these patients. A different mechanism leading to the production of hypercalcemia and/or bone destruction by cancer cells is considered. The results of this report suggest that parathyroid hormone production (P.T.H.) by the parathyroid glands is normal and that ectopic secretion of PTH or PTH‐like material is negligible in these cases.

[1]  R. Hutchinson,et al.  Elevated parathyroid hormone levels in association with rhabdomyosarcoma. , 1978, The Journal of pediatrics.

[2]  E. D. Bransome,et al.  Alkalotic disequilibrium in patients with solid tumors: rediscovery of an old finding. , 1977, European journal of cancer.

[3]  C. Galasko,et al.  Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins , 1976, Nature.

[4]  C. Galasko.  Mechanisms of bone destruction in the development of skeletal metastases , 1976, Nature.

[5]  Parfitt Am.  The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone diseases. II. PTH and bone cells: bone turnover and plasma calcium regulation. , 1976 .

[6]  T. Powles,et al.  Human breast tumour-induced osteolysis and prostaglandins. , 1976, Prostaglandins.

[7]  G. Mundy,et al.  Effect of osteoclast activating factor from human leukocytes on bone metabolism. , 1975, The Journal of clinical investigation.

[8]  Schussler Gc.  Letter: Renal function and neoplastic hypercalcemia. , 1974 .

[9]  B. Riggs,et al.  Radioimmunoassay of parathyroid hormone in hypercalcemic patients with malignant disease. , 1974, The American journal of medicine.

[10]  A. Tashjian.  Tumor Humors and the Hypercalcemias of Cancer , 1974 .

[11]  G. Gordan.  HYPER‐ AND HYPOCALCEMIA: PATHOGENESIS AND TREATMENTS , 1974 .

[12]  J. Bethune,et al.  EFFECTS OF NEOPLASMS ON RENAL ELECTROLYTE FUNCTION , 1974, Annals of the New York Academy of Sciences.

[13]  G. Canellos.  HYPERCALCEMIA IN MALIGNANT LYMPHOMA AND LEUKEMIA , 1974, Annals of the New York Academy of Sciences.

[14]  T. Powles,et al.  The Inhibition by Aspirin and Indomethacin of Osteolytic Tumour Deposits and Hypercalcaemia in Rats with Walker Tumour, and its Possible Application to Human Breast Cancer , 1973, British Journal of Cancer.

[15]  J. Potts,et al.  Nonparathyroid humoral hypercalcemia in patients with neoplastic diseases. , 1973, The New England journal of medicine.

[16]  A. Brickman,et al.  Hypercalcemia in reticulum cell sarcoma without hyperparathyroidism of skeletal metastases. , 1973, Annals of internal medicine.

[17]  Hao Li,et al.  Hypercalcemia in undifferentiated leukemia.Possible production of a parathormone‐like substance by leukemic cells , 1972, Cancer.

[18]  E. Kaplan,et al.  The effects of acute metabolic acid-base changes on secretion of gastrin and parathyroid hormone. , 1972, Surgery.

[19]  E. Kaplan,et al.  Acid-base balance and parathyroid function: metabolic alkalosis and hyperparathyroidism. , 1971, Surgery.

[20]  S. Berson,et al.  Clinical applications of radioimmunoassay of plasma parathyroid hormone. , 1971, The American journal of medicine.

[21]  R. C. Stein.  Hypercalcemia in leukemia. , 1971, The Journal of pediatrics.

[22]  C. Mallinson,et al.  Ectopic secretion of parathyroid hormone by a renal adenocarcinoma in a patient with hypercalcaemia. , 1970, British medical journal.

[23]  S. Helliwell,et al.  Relation of lactic and citric acid metabolism to bone resorption in tissue culture. , 1970, Clinical orthopaedics and related research.

[24]  K. E. Holley,et al.  Renal complications of lymphoma. , 1969, Annals of internal medicine.

[25]  H. O. Heinemann,et al.  Hypercalcemic crisis in acute leukemia. , 1969, The American journal of medicine.

[26]  G. Vaes.  On the mechanisms of bone resorption. The action of parathyroid hormone on the excretion and synthesis of lysosomal enzymes and on the extracellular release of acid by bone cells. , 1968 .

[27]  D. Simpson.  Regulation of renal citrate metabolism by bicarbonate ion and pH: observations in tissue slices and mitochondria. , 1967, The Journal of clinical investigation.

[28]  J. Potts,et al.  Production of parathyroid hormone by nonparthyroid tumors. , 1967, Journal of Clinical Endocrinology and Metabolism.

[29]  R. Yalow,et al.  Parathyroid Hormone in Plasma in Adenomatous Hyperparathyroidism, Uremia, and Bronchogenic Carcinoma , 1966, Science.

[30]  G. Jordan.  Serum calcium and phosphorus abnormalities in leukemia. , 1966, The American journal of medicine.

[31]  R. Knisley.  Hypercalcemia associated with leukemia. , 1966, Archives of internal medicine.

[32]  M. S. Albert,et al.  Acid-base equilibrium of blood in normal infants. , 1966, Pediatrics.

[33]  H. O. Heinemann.  Metabolic alkalosis in patients with hypercalcemia. , 1965, Metabolism: clinical and experimental.

[34]  L. Morse,et al.  Parathyroid hormone-secreting renal carcinoma associated with hypercalcemia and metabolic alkalosis. , 1965, Annals of internal medicine.

[35]  E. Freireich,et al.  LEUKOPENIA, BONE PAIN, AND BONE NECROSIS IN PATIENTS WITH ACUTE LEUKEMIA: A CLINICOPATHOLOGIC COMPLEX. , 1965, Annals of internal medicine.

[36]  S. Birge,et al.  Bone Cells: Biochemical and Biological Studies after Enzymatic Isolation , 1964, Science.

[37]  T. Reynolds,et al.  LEUKEMIA AND HYPERCALCEMIA; REPORT OF A CASE AND REVIEW OF THE LITERATURE. , 1964, The New England journal of medicine.

[38]  A. Tashjian,et al.  IMMUNOCHEMICAL IDENTIFICATION OF PARATHYROID HORMONE IN NON-PARATHYROID NEOPLASMS ASSOCIATED WITH HYPERCALCEMIA , 1964, The Journal of experimental medicine.

[39]  W. Gevers,et al.  THE EFFECT OF PH ON GLYCOLYSIS IN VITRO. , 1963, Clinical science.

[40]  A. Moses,et al.  HYPERCALCEMIA IN PATIENTS WITH MALIGNANT LYMPHOMA. , 1963, Annals of internal medicine.

[41]  C. Brindley,et al.  Serum lactic dehydrogenase and glutamic-oxaloacetic transminase correlations with measurements of tumor masses during therapy. , 1963, Cancer research.

[42]  Jacobs Hg,et al.  Renal involvement in lymphomas and leukemias in adults. , 1962 .

[43]  N. J. David,et al.  The diagnostic spectrum of hypercalcemia. Case reports and discussion. , 1962, The American journal of medicine.

[44]  G. Nichols,et al.  Concerning pH gradients between the extracellular compartment and fluids bathing the bone mineral surface and their relation to calcium ion distribution. , 1962, The Journal of clinical investigation.

[45]  L. Persky,et al.  The kidney in childhood leukemia. , 1962, Radiology.

[46]  R. J. Erickson,et al.  Clinical use of lactic dehydrogenase. , 1961, The New England journal of medicine.

[47]  O. Bodansky.  Biochemistry of Human Cancer , 1961 .

[48]  C. Forkner,et al.  The skeletal lesions of acute leukemia , 1961, Cancer.

[49]  G. Nichols,et al.  Metabolic studies of bone in vitro. I. Normal bone. , 1960, The Journal of biological chemistry.

[50]  W. Neuman,et al.  THE CHEMICAL DYNAMICS OF BONE MINERAL , 1959 .

[51]  R. Holman,et al.  Hypercalcaemia in acute leukaemia. , 1957, Lancet.

[52]  A. Gellhorn,et al.  Hypercalcemia in malignant disease without evidence of bone destruction. , 1956, The American journal of medicine.

[53]  F. Wróblewski,et al.  Lactic dehydrogenase activity of serum in mice with transplantable leukemia. , 1956, Science.

[54]  O. Warburg.  [Origin of cancer cells]. , 1956, Oncologia.

[55]  E. V. Cowdry,et al.  Serum Lactic Dehydrogenase Activity as Indication of Neoplastic Growth and Regression.∗ , 1955, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[56]  A. Smelin,et al.  Hypercalcemia secondary to bone metastases from carcinoma of the breast. I. Relationship between serum calcium and alkaline phosphatase values. , 1954, The Journal of clinical endocrinology and metabolism.

[57]  Jaffe Hl.  Skeletal manifestations of leukemia and malignant lymphoma. , 1952 .

[58]  P. Herbut,et al.  The bone changes of leukemia in children. , 1946, Radiology.

[59]  C. Cori,et al.  THE CARBOHYDRATE METABOLISM OF TUMORS II. CHANGES IN THE SUGAR, LACTIC ACID, AND CO2-COMBINING POWER OF BLOOD PASSING THROUGH A TUMOR , 1925 .

[60]  E. Conklin.  The Analysis of Racial Descent in Animals. , 1906, Science.