Chitosan-poly(ethylene oxide) nanofibrous mat as a vaginal platform for tenofovir disoproxyl fumarate - The effect of vaginal pH on drug carrier performance.

[1]  T. Ciach,et al.  Shear and elongational rheometry for determination of spinnability window of polymer solutions in solution blow spinning , 2022, Journal of Applied Polymer Science.

[2]  E. Chinarro,et al.  Optimized hydration dynamics in mucoadhesive xanthan-based trilayer vaginal films for the controlled release of tenofovir. , 2021, Carbohydrate polymers.

[3]  S. Van Vlierberghe,et al.  Design, preparation and in vitro characterization of biomimetic and bioactive chitosan/polyethylene oxide based nanofibers as wound dressings. , 2021, International journal of biological macromolecules.

[4]  B. Sarmento,et al.  Women-specific routes of administration for drugs: a critical overview. , 2021, Advanced drug delivery reviews.

[5]  T. Rashid,et al.  Mechanical Properties of Electrospun Fibers—A Critical Review , 2021, Advanced Engineering Materials.

[6]  K. Alexandre,et al.  Lobostemon trigonus (Thunb.) H. Buek, a medicinal plant from South Africa as a potential natural microbicide against HIV-1. , 2021, Journal of ethnopharmacology.

[7]  Sowjanya Gummadi,et al.  A Simple Stability Indicating Rp-Hplc-Dad Method For Concurrent Analysis Of Tenofovir Disoproxil Fumarate, Doravirine And Lamivudine In Pure Blend And Their Combined Film Coated Tablets. , 2021, Annales pharmaceutiques francaises.

[8]  B. Sarmento,et al.  Electrospun fibers for vaginal administration of tenofovir disoproxil fumarate and emtricitabine in the context of topical pre-exposure prophylaxis. , 2021, Journal of controlled release : official journal of the Controlled Release Society.

[9]  L. Bedoya,et al.  Smart vaginal bilayer films of Tenofovir based on Eudragit® L100/natural polymer for the prevention of the sexual transmission of HIV. , 2021, International journal of pharmaceutics.

[10]  P. Sajkiewicz,et al.  Solution Blow Spinning of Polycaprolactone—Rheological Determination of Spinnability and the Effect of Processing Conditions on Fiber Diameter and Alignment , 2021, Materials.

[11]  M. Krzyżowska,et al.  Potential of mucoadhesive chitosan glutamate microparticles as microbicide carriers – antiherpes activity and penetration behavior across the human vaginal epithelium , 2021, Drug delivery.

[12]  Manisha Pandey,et al.  Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update , 2020, Polymers.

[13]  L. Tijing,et al.  Solution blow spinning (SBS) and SBS-spun nanofibers: Materials, methods, and applications , 2020 .

[14]  T. Ciach,et al.  Superhydrophilic Polyurethane/Polydopamine Nanofibrous Materials Enhancing Cell Adhesion for Application in Tissue Engineering , 2020, International journal of molecular sciences.

[15]  K. Culwell,et al.  A novel vaginal pH regulator: results from the phase 3 AMPOWER contraception clinical trial☆☆☆★ , 2020, Contraception: X.

[16]  Jing Gao,et al.  Sequential release of drugs form a dual-delivery system based on pH-responsive nanofibrous mats towards wound care. , 2020, Journal of materials chemistry. B.

[17]  L. Bedoya,et al.  Vaginal Polyelectrolyte Layer-by-Layer Films Based on Chitosan Derivatives and Eudragit® S100 for pH Responsive Release of Tenofovir , 2020, Marine drugs.

[18]  M. Markuszewski,et al.  Could spray-dried microbeads with chitosan glutamate be considered as promising vaginal microbicide carriers? The effect of process variables on the in vitro functional and physicochemical characteristics. , 2019, International journal of pharmaceutics.

[19]  J. Billingsley,et al.  Tenofovir disoproxil fumarate intravaginal ring for HIV pre-exposure prophylaxis in sexually active women: a phase 1, single-blind, randomised, controlled trial. , 2019, The Lancet HIV.

[20]  A. Serrano-Medina,et al.  Mucoadhesive electrospun nanofibers for drug delivery systems: applications of polymers and the parameters’ roles , 2019, International journal of nanomedicine.

[21]  Y. Ni,et al.  Chitosan-based Polymer Matrix for Pharmaceutical Excipients and Drug Delivery. , 2019, Current medicinal chemistry.

[22]  B. Sarmento,et al.  Pharmaceutical Vehicles for Vaginal and Rectal Administration of Anti-HIV Microbicide Nanosystems , 2019, Pharmaceutics.

[23]  P. Ma,et al.  pH-responsive injectable hydrogels with mucosal adhesiveness based on chitosan-grafted-dihydrocaffeic acid and oxidized pullulan for localized drug delivery. , 2019, Journal of colloid and interface science.

[24]  B. Sarmento,et al.  Composite films for vaginal delivery of tenofovir disoproxil fumarate and emtricitabine , 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[25]  M. Másson,et al.  Antimicrobial Chitosan and Chitosan Derivatives: A Review of the Structure-Activity Relationship. , 2017, Biomacromolecules.

[26]  Suzanna C Francis,et al.  Sexually transmitted infections: challenges ahead. , 2017, The Lancet. Infectious diseases.

[27]  N. Durán,et al.  Electrospun poly(ethylene oxide)/chitosan nanofibers with cellulose nanocrystals as support for cell culture of 3T3 fibroblasts , 2017, Cellulose.

[28]  Kevin M. Tyo,et al.  Evaluation of poly(lactic-co-glycolic acid) and poly(dl-lactide-co-ε-caprolactone) electrospun fibers for the treatment of HSV-2 infection. , 2017, Materials science & engineering. C, Materials for biological applications.

[29]  Z. Shariatinia,et al.  Controlled release of cefazolin sodium antibiotic drug from electrospun chitosan-polyethylene oxide nanofibrous Mats. , 2017, Materials science & engineering. C, Materials for biological applications.

[30]  B. Sarmento,et al.  Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs. , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[31]  S. Baumgartner,et al.  Formulation and evaluation of chitosan/polyethylene oxide nanofibers loaded with metronidazole for local infections. , 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[32]  E. Fuchs,et al.  Comparison of Dapivirine Vaginal Gel and Film Formulation Pharmacokinetics and Pharmacodynamics (FAME 02B). , 2016, AIDS research and human retroviruses.

[33]  Sung Hyun Park,et al.  Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis , 2015, Antimicrobial Agents and Chemotherapy.

[34]  Wai Yee Chan,et al.  Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications , 2015, Marine drugs.

[35]  Xingyou Hu,et al.  Composite chitosan/poly(ethylene oxide) electrospun nanofibrous mats as novel wound dressing matrixes for the controlled release of drugs , 2015 .

[36]  Jing Gao,et al.  Antibacterial wound dressing from chitosan/polyethylene oxide nanofibers mats embedded with silver nanoparticles , 2015, Journal of biomaterials applications.

[37]  N. Škalko-Basnet,et al.  Chitosan in Mucoadhesive Drug Delivery: Focus on Local Vaginal Therapy , 2015, Marine drugs.

[38]  M. Pilarek,et al.  Comparative Studies of Electrospinning and Solution Blow Spinning Processes for the Production of Nanofibrous Poly(L-Lactic Acid) Materials for Biomedical Engineering , 2014 .

[39]  F. Rodrigues,et al.  Vaginal Mucosa and Drug Delivery , 2014 .

[40]  M. Dilamian,et al.  Nanofibrous Chitosan-Polyethylene Oxide Engineered Scaffolds: A Comparative Study between Simulated Structural Characteristics and Cells Viability , 2014, BioMed research international.

[41]  Clare F. McCoy,et al.  Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides. , 2014, Journal of pharmaceutical sciences.

[42]  P. Augustijns,et al.  In vitro profiling of the vaginal permeation potential of anti-HIV microbicides and the influence of formulation excipients. , 2012, Antiviral research.

[43]  S. Karim,et al.  CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck. , 2012, The Journal of infectious diseases.

[44]  Thomas J. Smith,et al.  Tenofovir and tenofovir disoproxil fumarate pharmacokinetics from intravaginal rings , 2012, AIDS.

[45]  R. Shattock,et al.  Microbicides: topical prevention against HIV. , 2012, Cold Spring Harbor perspectives in medicine.

[46]  J. Baeten,et al.  Tenofovir-based pre-exposure prophylaxis for HIV prevention: evolving evidence , 2012, Current opinion in infectious diseases.

[47]  B. Youan,et al.  Engineering tenofovir loaded chitosan nanoparticles to maximize microbicide mucoadhesion. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[48]  A. Nel,et al.  Acceptability of vaginal film, soft-gel capsule, and tablet as potential microbicide delivery methods among African women. , 2011, Journal of women's health.

[49]  Q. A. Karim,et al.  Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women , 2011, The Lancet.

[50]  Lynn Morris,et al.  Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women , 2010, Science.

[51]  C. Lim,et al.  Mechanical properties of electrospun collagen–chitosan complex single fibers and membrane , 2009 .

[52]  Xiaoyan Yuan,et al.  Preparation and antibacterial activity of electrospun chitosan/poly(ethylene oxide) membranes containing silver nanoparticles , 2009 .

[53]  D. Stefanidis,et al.  Evaluation of Polyethylene Oxide Compacts as Gastroretentive Delivery Systems , 2009, AAPS PharmSciTech.

[54]  S. Agarwal,et al.  Use of electrospinning technique for biomedical applications , 2008 .

[55]  R. Gorga,et al.  Fabrication and characterization of electrospun chitosan nanofibers formed via templating with polyethylene oxide. , 2008, Biomacromolecules.

[56]  V. Khutoryanskiy,et al.  Why is chitosan mucoadhesive? , 2008, Biomacromolecules.

[57]  S. Rossi,et al.  Strategies to Improve Systemic and Local Availability of Drugs Administered via Vaginal Route , 2006 .

[58]  William A. Lee,et al.  Perspectives on the development of acyclic nucleotide analogs as antiviral drugs. , 2006, Antiviral research.

[59]  G. Doncel,et al.  In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials. , 2005, AIDS research and human retroviruses.

[60]  S. Olofsson,et al.  Detection and Typing of Herpes Simplex Virus (HSV) in Mucocutaneous Samples by TaqMan PCR Targeting a gB Segment Homologous for HSV Types 1 and 2 , 2005, Journal of Clinical Microbiology.

[61]  John J. Lemasters,et al.  Mitochondrial Dysfunction in the Pathogenesis of Necrotic and Apoptotic Cell Death , 1999, Journal of bioenergetics and biomembranes.

[62]  D. Katz,et al.  A vaginal fluid simulant. , 1999, Contraception.

[63]  M. Mucha.  Rheological characteristics of semi‐dilute chitosan solutions , 1997 .

[64]  Yonghou Jiang,et al.  Tunable Release of Multiclass Anti-HIV Drugs that are Water-Soluble and Loaded at High Drug Content in Polyester Blended Electrospun Fibers , 2015, Pharmaceutical Research.

[65]  Ananya Das,et al.  Vaginal pH: A marker for menopause , 2014, Journal of mid-life health.

[66]  J. Rosiak,et al.  DETERMINATION OF DEGREE OF DEACETYLATION OF CHITOSAN - COMPARISION OF METHODS , 2012 .

[67]  H. Matthews,et al.  The lowry method for protein quantitation. , 1984, Methods in molecular biology.