Primitive origins of prostate cancer: In vivo evidence for prostate‐regenerating cells and prostate cancer‐initiating cells

[1]  Jiaoti Huang,et al.  Identification of a Cell of Origin for Human Prostate Cancer , 2010, Science.

[2]  Zhiwei Wang,et al.  Down‐regulation of Notch‐1 and Jagged‐1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF‐κB signaling pathways , 2010, Journal of cellular biochemistry.

[3]  Jiaoti Huang,et al.  A seminal finding for prostate cancer? , 2010, The New England journal of medicine.

[4]  S. Memarzadeh,et al.  Basal epithelial stem cells are efficient targets for prostate cancer initiation , 2010, Proceedings of the National Academy of Sciences.

[5]  J. Epstein.  Prostatic Ductal Adenocarcinoma: A Mini Review , 2009, Medical Principles and Practice.

[6]  M. Rubin,et al.  Human Prostate Sphere-Forming Cells Represent a Subset of Basal Epithelial Cells Capable of Glandular Regeneration in Vivo , 2009, The Prostate.

[7]  O. Witte,et al.  Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. , 2009, Cancer research.

[8]  D. Moscatelli,et al.  High Aldehyde Dehydrogenase Activity: A Novel Functional Marker of Murine Prostate Stem/Progenitor Cells , 2009, Stem cells.

[9]  Howard Y. Chang,et al.  Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells , 2009, Proceedings of the National Academy of Sciences.

[10]  M. Shen,et al.  A luminal epithelial stem cell that is a cell of origin for prostate cancer , 2009, Nature.

[11]  Scott H. Randell,et al.  Basal cells as stem cells of the mouse trachea and human airway epithelium , 2009, Proceedings of the National Academy of Sciences.

[12]  S. Fox,et al.  Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers , 2009, Nature Medicine.

[13]  C. Perou,et al.  Mammary development meets cancer genomics , 2009, Nature Medicine.

[14]  M. Teitell,et al.  ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells , 2009, Proceedings of the National Academy of Sciences.

[15]  T. H. van der Kwast,et al.  Accumulating Progenitor Cells in the Luminal Epithelial Cell Layer Are Candidate Tumor Initiating Cells in a Pten Knockout Mouse Prostate Cancer Model , 2009, PloS one.

[16]  K. Williams,et al.  Selective expression of CD44, a putative prostate cancer stem cell marker, in neuroendocrine tumor cells of human prostate cancer , 2009, The Prostate.

[17]  Hans Clevers,et al.  Crypt stem cells as the cells-of-origin of intestinal cancer , 2009, Nature.

[18]  O. Witte,et al.  Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics , 2008, Proceedings of the National Academy of Sciences.

[19]  K. Leong,et al.  Generation of a prostate from a single adult stem cell , 2008, Nature.

[20]  G. Turashvili,et al.  A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability , 2008, Nature Medicine.

[21]  A. DeMarzo,et al.  The role of CD133 in normal human prostate stem cells and malignant cancer-initiating cells. , 2008, Cancer research.

[22]  S. Dehm.  A causal role for ERG in neoplastic transformation of prostate epithelium. Klezovitch O, Risk M, Coleman I, Lucas JM, Null M, True LD, Nelson PS, Vasioukhin V, Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA , 2008 .

[23]  R. Richardson,et al.  Prominin1 marks intestinal stem cells that are susceptible to neoplastic transformation , 2008, Nature.

[24]  S. Morrison,et al.  Efficient tumor formation by single human melanoma cells , 2008, Nature.

[25]  S. Salm,et al.  Axin2 expression identifies progenitor cells in the murine prostate , 2008, The Prostate.

[26]  Jun Luo,et al.  Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis , 2008, Modern Pathology.

[27]  J. Lees,et al.  Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion , 2008, Proceedings of the National Academy of Sciences.

[28]  K. Leong,et al.  The Notch pathway in prostate development and cancer. , 2008, Differentiation; research in biological diversity.

[29]  R. Behringer,et al.  Horizontal Basal Cells Are Multipotent Progenitors in Normal and Injured Adult Olfactory Epithelium , 2008, Stem cells.

[30]  S. Signoretti,et al.  p63 in prostate biology and pathology , 2008, Journal of cellular biochemistry.

[31]  P. Nelson,et al.  A causal role for ERG in neoplastic transformation of prostate epithelium , 2008, Proceedings of the National Academy of Sciences.

[32]  E. Hurt,et al.  CD44+CD24− prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis , 2008, British Journal of Cancer.

[33]  T. Reya,et al.  Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In Vivo , 2007 .

[34]  W. Bushman,et al.  Anchorage-independent culture maintains prostate stem cells. , 2007, Developmental biology.

[35]  D. Birnbaum,et al.  ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. , 2007, Cell stem cell.

[36]  O. Witte,et al.  Self‐Renewal and Multilineage Differentiation In Vitro from Murine Prostate Stem Cells , 2007, Stem cells.

[37]  H. Clevers,et al.  Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.

[38]  C. Sherr,et al.  Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia. , 2007, Genes & development.

[39]  S. Dhanasekaran,et al.  Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer , 2007, Nature.

[40]  J Alfred Witjes,et al.  Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features. , 2007, European urology.

[41]  Aleksandar Dakic,et al.  Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells , 2007, Science.

[42]  R. Schneider-Broussard,et al.  Hierarchical Organization of Prostate Cancer Cells in Xenograft Tumors: The CD44+α2β1+ Cell Population Is Enriched in Tumor-Initiating Cells , 2007 .

[43]  Liang Cheng,et al.  Function and molecular mechanisms of neuroendocrine cells in prostate cancer. , 2007, Analytical and quantitative cytology and histology.

[44]  Marie-Liesse Asselin-Labat,et al.  Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation , 2007, Nature Cell Biology.

[45]  J. Dick,et al.  A human colon cancer cell capable of initiating tumour growth in immunodeficient mice , 2007, Nature.

[46]  O. Witte,et al.  Isolation and functional characterization of murine prostate stem cells , 2007, Proceedings of the National Academy of Sciences.

[47]  Zhiwei Wang,et al.  Retracted: Down‐regulation of Jagged‐1 induces cell growth inhibition and S phase arrest in prostate cancer cells , 2006, International journal of cancer.

[48]  P. di Sant'Agnese,et al.  Immunohistochemical characterization of neuroendocrine cells in prostate cancer , 2006, The Prostate.

[49]  Paulo A. S. Nuin,et al.  Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias. , 2006, Cancer genetics and cytogenetics.

[50]  T. Golub,et al.  Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9 , 2006, Nature.

[51]  R. Hoffman,et al.  Essential Role for Activation of the Polycomb Group (PcG) Protein Chromatin Silencing Pathway in Metastatic Prostate Cancer , 2006, Cell cycle.

[52]  H. Li,et al.  Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells , 2006, Oncogene.

[53]  Haiyan I. Li,et al.  Purification and unique properties of mammary epithelial stem cells , 2006, Nature.

[54]  Zhijun Tang,et al.  Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. , 2006, Developmental biology.

[55]  Shunyou Wang,et al.  Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[56]  François Vaillant,et al.  Generation of a functional mammary gland from a single stem cell , 2006, Nature.

[57]  N. Maitland,et al.  Prospective identification of tumorigenic prostate cancer stem cells. , 2005, Cancer research.

[58]  H. Scher,et al.  Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[59]  A. D. De Marzo,et al.  Role of notch-1 and E-cadherin in the differential response to calcium in culturing normal versus malignant prostate cells. , 2005, Cancer research.

[60]  T. H. van der Kwast,et al.  Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. , 2005, Cancer research.

[61]  G. Glinsky,et al.  Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. , 2005, The Journal of clinical investigation.

[62]  D. Moscatelli,et al.  Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[63]  O. Witte,et al.  The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[64]  M. Walker,et al.  Hey1, a Mediator of Notch Signaling, Is an Androgen Receptor Corepressor , 2005, Molecular and Cellular Biology.

[65]  R. Henkelman,et al.  Identification of human brain tumour initiating cells , 2004, Nature.

[66]  K. Akashi,et al.  MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. , 2004, Cancer cell.

[67]  I. Weissman,et al.  JunB Deficiency Leads to a Myeloproliferative Disorder Arising from Hematopoietic Stem Cells , 2004, Cell.

[68]  A. Potti,et al.  Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications. , 2004, Cancer.

[69]  Elaine Fuchs,et al.  Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche , 2004, Cell.

[70]  C. Robson,et al.  CD133, a novel marker for human prostatic epithelial stem cells , 2004, Journal of Cell Science.

[71]  Simon C Watkins,et al.  Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. , 2004, The American journal of pathology.

[72]  I. Weissman,et al.  Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. , 2003, Genes & development.

[73]  O. Witte,et al.  In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[74]  T. Graeber,et al.  Myc-driven murine prostate cancer shares molecular features with human prostate tumors. , 2003, Cancer cell.

[75]  R. Cardiff,et al.  Activation of β-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation , 2003, Oncogene.

[76]  R. Vessella,et al.  LuCaP 35: A new model of prostate cancer progression to androgen independence , 2003, The Prostate.

[77]  G. Dontu,et al.  In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. , 2003, Genes & development.

[78]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[79]  I. Weissman,et al.  MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. , 2003, Cancer cell.

[80]  T. Sun,et al.  Proximal location of mouse prostate epithelial stem cells , 2002, The Journal of cell biology.

[81]  P. Rennie,et al.  The Androgen Receptor Can Promote β-Catenin Nuclear Translocation Independently of Adenomatous Polyposis Coli* , 2002, The Journal of Biological Chemistry.

[82]  D. Longo,et al.  Linking β-Catenin to Androgen-signaling Pathway* , 2002, The Journal of Biological Chemistry.

[83]  C. Huggins,et al.  Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941. , 2002, The Journal of urology.

[84]  D. Neal,et al.  Identification and isolation of human prostate epithelial stem cells based on alpha(2)beta(1)-integrin expression. , 2001, Journal of cell science.

[85]  I. Weissman,et al.  Stem cells, cancer, and cancer stem cells , 2001, Nature.

[86]  H. Koeppen,et al.  Dynamics of notch expression during murine prostate development and tumorigenesis. , 2001, Cancer research.

[87]  C. Eaves,et al.  Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue , 2001, Breast Cancer Research and Treatment.

[88]  A. Belldegrun,et al.  WISH-PC2: a unique xenograft model of human prostatic small cell carcinoma. , 2000, Cancer research.

[89]  S. Schwartz,et al.  Prostate cancer and other xenografts from cells in peripheral blood of patients. , 2000, Cancer research.

[90]  J. Schalken,et al.  Demonstration of Intermediate Cells during Human Prostate Epithelial Differentiation In Situ and In Vitro Using Triple-Staining Confocal Scanning Microscopy , 2000, Laboratory Investigation.

[91]  I. Weissman,et al.  A clonogenic common myeloid progenitor that gives rise to all myeloid lineages , 2000, Nature.

[92]  J. Hugosson,et al.  Regressive changes and neuroendocrine differentiation in prostate cancer after neoadjuvant hormonal treatment , 2000, The Prostate.

[93]  A. Bjartell,et al.  Neurogenic origin of human prostate endocrine cells. , 1999, Urology.

[94]  R. Reiter,et al.  Stem Cell Genes in Androgen-independent Prostate Cancer , 1998, Cancer and Metastasis Reviews.

[95]  A. Collins,et al.  Basal cells are progenitors of luminal cells in primary cultures of differentiating human prostatic epithelium , 1998, The Prostate.

[96]  C. Eaves,et al.  Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast. , 1998, Differentiation; research in biological diversity.

[97]  J. Dick,et al.  Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[98]  A. Bjartell,et al.  Neuroendocrine differentiation in prostatic carcinoma during hormonal treatment. , 1998, Urology.

[99]  J. Dick,et al.  Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell , 1997, Nature Medicine.

[100]  K. A. Klein,et al.  Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice , 1997, Nature Medicine.

[101]  R L Vessella,et al.  Characterization of a novel androgen-sensitive, prostate-specific antigen-producing prostatic carcinoma xenograft: LuCaP 23. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[102]  S. Weiss,et al.  Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. , 1996, Developmental biology.

[103]  S. Schwartz,et al.  CWR22: androgen-dependent xenograft model derived from a primary human prostatic carcinoma. , 1994, Cancer research.

[104]  I. Weissman,et al.  The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. , 1994, Immunity.

[105]  M. Caligiuri,et al.  A cell initiating human acute myeloid leukaemia after transplantation into SCID mice , 1994, Nature.

[106]  T. H. van der Kwast,et al.  Do neuroendocrine cells in human prostate cancer express androgen receptor? , 1993, Histochemistry.

[107]  M. Resnick,et al.  Xenografts of primary human prostatic carcinoma. , 1993, Journal of the National Cancer Institute.

[108]  M. Campbell,et al.  Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. , 1992, Cancer research.

[109]  J. Schalken,et al.  Colocalization of basal and luminal cell-type cytokeratins in human prostate cancer. , 1992, Cancer research.

[110]  P. A. Sant'agnese,et al.  Neuroendocrine differentiation in human prostatic carcinoma , 1992 .

[111]  L. Grimelius,et al.  The course of neuroendocrine differentiation in prostatic carcinomas. An immunohistochemical study testing chromogranin A as an "endocrine marker". , 1989, Pathology, research and practice.

[112]  T. Sun,et al.  Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: Implications on epithelial stem cells , 1989, Cell.

[113]  P. di Sant'Agnese,et al.  Neuroendocrine differentiation in prostatic carcinoma. , 1987, Human pathology.

[114]  G. Cunha,et al.  The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild-type and androgen-insensitive (Tfm) mice. , 1978, The Journal of experimental zoology.

[115]  C. Huggins.  ENDOCRINE CONTROL OF PROSTATIC CANCER. , 1943, Science.

[116]  C. Huggins,et al.  Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. , 1941, CA: a cancer journal for clinicians.

[117]  S. Memarzadeh,et al.  Epithelial stem cells of the prostate and their role in cancer progression. , 2008, Cold Spring Harbor symposia on quantitative biology.

[118]  Mark Shackleton,et al.  Efficient tumour formation by single human melanoma cells , 2008 .

[119]  R. Schneider-Broussard,et al.  Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44+alpha2beta1+ cell population is enriched in tumor-initiating cells. , 2007, Cancer research.

[120]  A. Okamura,et al.  Keratin profiles in normal/hyperplastic prostates and prostate carcinoma , 2005, Virchows Archiv A.

[121]  U. Stein,et al.  Androgen receptor status in endocrine-paracrine cell types of the normal, hyperplastic, and neoplastic human prostate , 2005, Virchows Archiv A.

[122]  S. Catz,et al.  BCL-2 in prostate cancer: A minireview , 2004, Apoptosis.

[123]  A. Belldegrun,et al.  WISH-PC 2 : A Unique Xenograft Model of Human Prostatic Small Cell Carcinoma 1 , 2000 .

[124]  Taylor Murray,et al.  Cancer statistics, 2000 , 2000, CA: a cancer journal for clinicians.

[125]  I. Weissman,et al.  The biology of hematopoietic stem cells. , 1995, Annual review of cell and developmental biology.

[126]  M. Bohrer,et al.  [Immunohistochemical and morphometric studies on neuroendocrine differentiation of prostate carcinomas]. , 1993, Verhandlungen der Deutschen Gesellschaft fur Pathologie.

[127]  P. di Sant'Agnese,et al.  Neuroendocrine differentiation in human prostatic carcinoma. , 1992, Human pathology.

[128]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.

[129]  R. Santen,et al.  Response of glandular versus basal rat ventral prostatic epithelial cells to androgen withdrawal and replacement , 1987, The Prostate.

[130]  Nicola K. Wilson,et al.  Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators , 2011, Developmental cell.