siRNA delivery systems for cancer treatment.

[1]  Y. Maitani,et al.  Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[2]  Dale L. Greiner,et al.  T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice , 2008, Cell.

[3]  M. Hensel,et al.  Small interfering RNA (siRNA) delivery into murine bone marrow-derived dendritic cells by electroporation. , 2008, Journal of immunological methods.

[4]  John J Rossi,et al.  Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

[5]  M. Ogris,et al.  Induction of apoptosis in murine neuroblastoma by systemic delivery of transferrin-shielded siRNA polyplexes for downregulation of Ran. , 2008, Oligonucleotides.

[6]  T. Park,et al.  Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[7]  Ji-Eun Kim,et al.  Poly(ester amine)-mediated, aerosol-delivered Akt1 small interfering RNA suppresses lung tumorigenesis. , 2008, American journal of respiratory and critical care medicine.

[8]  R. Juliano,et al.  Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides , 2008, Nucleic acids research.

[9]  Doheon Lee,et al.  AsiDesigner: exon-based siRNA design server considering alternative splicing , 2008, Nucleic Acids Res..

[10]  Yuhan Lee,et al.  Cationic solid lipid nanoparticles reconstituted from low density lipoprotein components for delivery of siRNA. , 2008, Molecular pharmaceutics.

[11]  Robert Langer,et al.  A combinatorial library of lipid-like materials for delivery of RNAi therapeutics , 2008, Nature Biotechnology.

[12]  M. Rubin Targeted therapy of cancer: new roles for pathologists—prostate cancer , 2008, Modern Pathology.

[13]  S. Takeoka,et al.  Evaluation of cationic assemblies constructed with amino acid based lipids for plasmid DNA delivery. , 2008, Bioconjugate chemistry.

[14]  Justine R. Smith,et al.  Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 , 2008, Nature.

[15]  Liz Y. Han,et al.  Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth. , 2008, Journal of the National Cancer Institute.

[16]  K. Ui-Tei,et al.  New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer , 2008, Cancer Gene Therapy.

[17]  A. Akinc,et al.  Delivering silence: advancements in developing siRNA therapeutics. , 2008, Current opinion in drug discovery & development.

[18]  S. Elbashir,et al.  Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). , 2008, Antiviral research.

[19]  Leaf Huang,et al.  Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[20]  D. Peer,et al.  Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target , 2008, Science.

[21]  Ting Liu,et al.  Calcium carbonate nanoparticle delivering vascular endothelial growth factor-C siRNA effectively inhibits lymphangiogenesis and growth of gastric cancer in vivo , 2008, Cancer Gene Therapy.

[22]  L. Ellis,et al.  Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver. , 2008, Journal of the National Cancer Institute.

[23]  P. Couvreur,et al.  siRNA nanoformulation against the Ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma , 2007, Nucleic acids research.

[24]  A. Gewirtz On future's doorstep: RNA interference and the pharmacopeia of tomorrow. , 2007, The Journal of clinical investigation.

[25]  S. Nakaike,et al.  Modulation of scratching behavior by silencing an endogenous cyclooxygenase‐1 gene in the skin through the administration of siRNA , 2007, The journal of gene medicine.

[26]  Michael S. Goldberg,et al.  Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway , 2007, Nature.

[27]  W. Pardridge,et al.  Intravenous siRNA of Brain Cancer with Receptor Targeting and Avidin–Biotin Technology , 2007, Pharmaceutical Research.

[28]  S. Choi,et al.  Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[29]  C. Lavigne,et al.  Specific subcellular localization of siRNAs delivered by lipoplex in MCF-7 breast cancer cells. , 2007, Biochimie.

[30]  M. Stoffel,et al.  Mechanisms and optimization of in vivo delivery of lipophilic siRNAs , 2007, Nature Biotechnology.

[31]  B. Lebleu,et al.  Inhibition of PAI-1 expression in breast cancer carcinoma cells by siRNA at nanomolar range. , 2007, Biochimie.

[32]  Wolfgang A. Weber,et al.  Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging , 2007, Proceedings of the National Academy of Sciences.

[33]  Simon W. Jones,et al.  Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity. , 2007, Bioconjugate chemistry.

[34]  Y. Won,et al.  Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[35]  P. Arbuthnot,et al.  Opportunities for treating chronic hepatitis B and C virus infection using RNA interference , 2007, Journal of viral hepatitis.

[36]  Judy Lieberman,et al.  Interfering with disease: a progress report on siRNA-based therapeutics , 2007, Nature Reviews Drug Discovery.

[37]  G. Cheon,et al.  Systemic and specific delivery of small interfering RNAs to the liver mediated by apolipoprotein A-I. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

[38]  A. Aigner Nonviral in vivo delivery of therapeutic small interfering RNAs. , 2007, Current opinion in molecular therapeutics (Print).

[39]  J Teissié,et al.  In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery , 2007, Gene Therapy.

[40]  Mark E. Davis,et al.  Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA , 2007, Proceedings of the National Academy of Sciences.

[41]  Steven F Dowdy,et al.  Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides. , 2007, Advanced drug delivery reviews.

[42]  Shan Jiang,et al.  Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference. , 2007, Biomaterials.

[43]  John J. Rossi,et al.  Strategies for silencing human disease using RNA interference , 2007, Nature Reviews Genetics.

[44]  J. Carlquist,et al.  Gene mutations, atrial fibrillation, and the elusive cigar , 2007, Clinical pharmacology and therapeutics.

[45]  M. Manoharan,et al.  RNAi therapeutics: a potential new class of pharmaceutical drugs , 2006, Nature chemical biology.

[46]  A. C. Hunter Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity. , 2006, Advanced drug delivery reviews.

[47]  Soo Hyun Lee,et al.  PEG conjugated VEGF siRNA for anti-angiogenic gene therapy. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[48]  P. Opolon,et al.  Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer. , 2006, Human gene therapy.

[49]  T. Ochiya,et al.  Atelocollagen‐Mediated Systemic DDS for Nucleic Acid Medicines , 2006, Annals of the New York Academy of Sciences.

[50]  Kenneth A Howard,et al.  RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[51]  Ho Sup Yoon,et al.  Co-delivery of drugs and DNA from cationic core–shell nanoparticles self-assembled from a biodegradable copolymer , 2006, Nature materials.

[52]  T. Kissel,et al.  Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes. , 2006, Bioconjugate chemistry.

[53]  A. Klippel,et al.  RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy , 2006, Gene Therapy.

[54]  Qi Zhou,et al.  Chemically Modified Short Interfering Hybrids (siHYBRIDS): Nanoimmunoliposome Delivery In Vitro and In Vivo for RNAi of HER-2 , 2006, Nucleosides, nucleotides & nucleic acids.

[55]  T. Ochiya,et al.  Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer. , 2006, International journal of oncology.

[56]  Liz Y. Han,et al.  Focal Adhesion Kinase Targeting Using In vivo Short Interfering RNA Delivery in Neutral Liposomes for Ovarian Carcinoma Therapy , 2006, Clinical Cancer Research.

[57]  Yuan Zhang,et al.  Delivery of Telomerase Reverse Transcriptase Small Interfering RNA in Complex with Positively Charged Single-Walled Carbon Nanotubes Suppresses Tumor Growth , 2006, Clinical Cancer Research.

[58]  Shubiao Zhang,et al.  Toxicity of cationic lipids and cationic polymers in gene delivery. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[59]  D. Bunka,et al.  Aptamers come of age – at last , 2006, Nature Reviews Microbiology.

[60]  Liz Y. Han,et al.  Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma , 2006, Nature Medicine.

[61]  Amy C Richards Grayson,et al.  Biophysical and Structural Characterization of Polyethylenimine-Mediated siRNA Delivery in Vitro , 2006, Pharmaceutical Research.

[62]  A. Aigner,et al.  RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts. , 2006, Human gene therapy.

[63]  Leaf Huang,et al.  Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells. , 2006, Molecular pharmaceutics.

[64]  L. Lim,et al.  Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. , 2006, RNA.

[65]  Yong Wang,et al.  Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras , 2006, Nature Biotechnology.

[66]  P. Jahrling,et al.  Postexposure Protection of Guinea Pigs against a Lethal Ebola Virus Challenge Is Conferred by RNA Interference , 2006, The Journal of infectious diseases.

[67]  B. Baker,et al.  RNA interference by 2',5'-linked nucleic acid duplexes in mammalian cells. , 2006, Bioorganic & medicinal chemistry letters.

[68]  Andrew D. Ellington,et al.  Aptamer mediated siRNA delivery , 2006, Nucleic acids research.

[69]  Jinming Gao,et al.  Efficient suppression of secretory clusterin levels by polymer-siRNA nanocomplexes enhances ionizing radiation lethality in human MCF-7 breast cancer cells in vitro* , 2006, International journal of nanomedicine.

[70]  Matthias John,et al.  RNAi-mediated gene silencing in non-human primates , 2006, Nature.

[71]  In Ho Song,et al.  In vitro and in vivo gene-transferring characteristics of novel cationic lipids, DMKD (O,O'-dimyristyl-N-lysyl aspartate) and DMKE (O,O'-dimyristyl-N-lysyl glutamate). , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[72]  R. Schiffelers,et al.  ICS-283: a system for targeted intravenous delivery of siRNA , 2006, Expert opinion on drug delivery.

[73]  A. Klippel,et al.  A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium , 2006, Gene Therapy.

[74]  Anil K Sood,et al.  Intraperitoneal delivery of liposomal siRNA for therapy of advanced ovarian cancer , 2006, Cancer biology & therapy.

[75]  M. Behlke Progress towards in Vivo Use of siRNAs , 2006, Molecular Therapy.

[76]  V. Torchilin,et al.  siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene , 2006, Journal of Controlled Release.

[77]  T. Wu,et al.  Prospects of RNA interference therapy for cancer , 2006, Gene Therapy.

[78]  R. Griffey,et al.  Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications. , 2006, Journal of medicinal chemistry.

[79]  Qi Zhou,et al.  Tumor-targeting nanoimmunoliposome complex for short interfering RNA delivery. , 2005, Human gene therapy.

[80]  B. Williams,et al.  Activation of the mammalian immune system by siRNAs , 2005, Nature Biotechnology.

[81]  Hongtao Liao,et al.  Biomembrane-permeable and Ribonuclease-resistant siRNA with enhanced activity. , 2005, Oligonucleotides.

[82]  Mark E. Davis,et al.  Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. , 2005, Cancer research.

[83]  M. Hung,et al.  Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[84]  Phillip D. Zamore,et al.  Ribo-gnome: The Big World of Small RNAs , 2005, Science.

[85]  T. Ochiya,et al.  Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[86]  Anil K Sood,et al.  Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. , 2005, Cancer research.

[87]  Keith Bowman,et al.  Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs , 2005, Nature Biotechnology.

[88]  J. Nah,et al.  Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[89]  Judy Lieberman,et al.  Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors , 2005, Nature Biotechnology.

[90]  B. Polisky,et al.  Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication , 2005, Hepatology.

[91]  P. Whittaker,et al.  RNA interference: From gene silencing to gene-specific therapeutics , 2005, Pharmacology & Therapeutics.

[92]  F. He,et al.  Cationic lipids enhance siRNA-mediated interferon response in mice. , 2005, Biochemical and biophysical research communications.

[93]  A. Judge,et al.  Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA , 2005, Nature Biotechnology.

[94]  I. Ahmad,et al.  Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. , 2005, International journal of oncology.

[95]  R. Schiffelers,et al.  Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. , 2005, Arthritis and rheumatism.

[96]  Thomas Tuschl,et al.  Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein , 2005, Nature.

[97]  A. Aigner,et al.  RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo , 2005, Gene Therapy.

[98]  P. Chien,et al.  Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo , 2005, Cancer Gene Therapy.

[99]  S. Akira,et al.  Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7 , 2005, Nature Medicine.

[100]  D. Barford,et al.  Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity , 2004, The EMBO journal.

[101]  Raymond M Schiffelers,et al.  Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. , 2004, The American journal of pathology.

[102]  T. Irimura,et al.  Antitumor Activity of Small Interfering RNA/Cationic Liposome Complex in Mouse Models of Cancer , 2004, Clinical Cancer Research.

[103]  Matthias John,et al.  Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs , 2004, Nature.

[104]  C. Culmsee,et al.  Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer , 2004, The journal of gene medicine.

[105]  J. M. Thomson,et al.  Argonaute2 Is the Catalytic Engine of Mammalian RNAi , 2004, Science.

[106]  T. Rana,et al.  Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. , 2004, Chemistry & biology.

[107]  K. Kinzler,et al.  Cancer genes and the pathways they control , 2004, Nature Medicine.

[108]  T. Tuschl,et al.  Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. , 2004, Molecular cell.

[109]  Y. Yuzawa,et al.  A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics , 2004, Cancer Research.

[110]  Anton P. McCaffrey,et al.  In vivo activity of nuclease-resistant siRNAs. , 2004, RNA.

[111]  M. Eccles,et al.  Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells , 2004, FEBS letters.

[112]  T. Rana,et al.  siRNA function in RNAi: a chemical modification analysis. , 2003, RNA.

[113]  David R Corey,et al.  RNA interference in mammalian cells by chemically-modified RNA. , 2003, Biochemistry.

[114]  A. Klippel,et al.  Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells. , 2003, Nucleic acids research.

[115]  Thomas Tuschl,et al.  Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. , 2003, Antisense & nucleic acid drug development.

[116]  Judy Lieberman,et al.  RNA interference targeting Fas protects mice from fulminant hepatitis , 2003, Nature Medicine.

[117]  Kaoru Saigo,et al.  Short-Interfering-RNA-Mediated Gene Silencing in Mammalian Cells Requires Dicer and eIF2C Translation Initiation Factors , 2003, Current Biology.

[118]  A. Klibanov,et al.  Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[119]  D. Fischer,et al.  Copolymers of ethylene imine and N-(2-hydroxyethyl)-ethylene imine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexes. , 2002, Bioconjugate chemistry.

[120]  J. Lieberman,et al.  siRNA-directed inhibition of HIV-1 infection , 2002, Nature Medicine.

[121]  C. Ahn,et al.  Biodegradable poly(ethylenimine) for plasmid DNA delivery. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[122]  T. Tuschl,et al.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.

[123]  S. Hammond,et al.  An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells , 2000, Nature.

[124]  T. Ochiya,et al.  New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the Minipellet , 1999, Nature Medicine.

[125]  A. Fire,et al.  Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans , 1998, Nature.

[126]  J. Behr,et al.  Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold. , 1996, Gene therapy.

[127]  N. O’higgins,et al.  Advances in treatment of breast cancer. , 1978, Irish medical journal.

[128]  Yun Chen,et al.  Tumor-targeted delivery of siRNA by self-assembled nanoparticles. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

[129]  S. Pun,et al.  Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers. , 2004, Current medicinal chemistry.

[130]  K. Alexander,et al.  RNA interference using boranophosphate siRNAs: structure-activity relationships. , 2004, Nucleic acids research.

[131]  Chen Yi,et al.  On Evaluation of Safety , 2000 .

[132]  P. Felgner,et al.  Cationic liposome mediated transfection. , 1989, Proceedings of the Western Pharmacology Society.