Disease progression promotes changes in adipose tissue signatures in type 2 diabetic (db/db) mice: The potential pathophysiological role of batokines.

[1]  M. E. Starr,et al.  Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation , 2022, GeroScience.

[2]  H. Fang,et al.  Gene–Environment Interaction on Type 2 Diabetes Risk among Chinese Adults Born in Early 1960s , 2022, Genes.

[3]  C. Mandarim-de-Lacerda,et al.  Progressive brown adipocyte dysfunction: whitening and impaired nonshivering thermogenesis as long-term obesity complications. , 2022, The Journal of nutritional biochemistry.

[4]  P. Seale,et al.  Adipose-tissue plasticity in health and disease , 2022, Cell.

[5]  Xianbo Jia,et al.  De Novo Reconstruction of Transcriptome Identified Long Non-Coding RNA Regulator of Aging-Related Brown Adipose Tissue Whitening in Rabbits , 2021, Biology.

[6]  R. Singh,et al.  Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues , 2021, Cells.

[7]  R. Curi,et al.  Impaired brown adipose tissue is differentially modulated in insulin-resistant obese wistar and type 2 diabetic Goto-Kakizaki rats. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[8]  F. Villarroya,et al.  A Differential Pattern of Batokine Expression in Perivascular Adipose Tissue Depots From Mice , 2021, Frontiers in Physiology.

[9]  K. Suchacki,et al.  Nutritional Regulation of Human Brown Adipose Tissue , 2021, Nutrients.

[10]  B. Kwak,et al.  Browning of White Adipose Tissue as a Therapeutic Tool in the Fight against Atherosclerosis , 2021, Metabolites.

[11]  U. Wankhade,et al.  Beige Adipose Tissue Identification and Marker Specificity—Overview , 2021, Frontiers in Endocrinology.

[12]  P. Gao,et al.  Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ , 2021, Frontiers in Cell and Developmental Biology.

[13]  L. Lind,et al.  Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study , 2021, EBioMedicine.

[14]  I. Fong,et al.  Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines. , 2021 .

[15]  P. Sanders,et al.  Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality. , 2020, Journal of the American College of Cardiology.

[16]  K. Stanford,et al.  Exercise-Induced Adaptations to Adipose Tissue Thermogenesis , 2020, Frontiers in Endocrinology.

[17]  A. Kappo,et al.  Isoorientin ameliorates lipid accumulation by regulating fat browning in palmitate-exposed 3T3-L1 adipocytes , 2020, Metabolism open.

[18]  F. Tinahones,et al.  Adipose tissue depot‐specific intracellular and extracellular cues contributing to insulin resistance in obese individuals , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  Yingshan Liu,et al.  Integrative analyses of biomarkers and pathways for adipose tissue after bariatric surgery , 2020, Adipocyte.

[20]  Fabio Marcheggiani,et al.  A systematic review on the functional role of Th1/Th2 cytokines in type 2 diabetes and related metabolic complications. , 2019, Cytokine.

[21]  T. Quesada-López,et al.  Brown Adipocytes Secrete GDF15 in Response to Thermogenic Activation , 2019, Obesity.

[22]  P. Formisano,et al.  Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications , 2019, International journal of molecular sciences.

[23]  P. Mancuso,et al.  The Impact of Aging on Adipose Function and Adipokine Synthesis , 2019, Front. Endocrinol..

[24]  A. Xu,et al.  Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. , 2019, Cell reports.

[25]  Nathan R. Qi,et al.  Adipose tissue senescence and inflammation in aging is reversed by the young milieu. , 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

[26]  M. Kratz,et al.  Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus. , 2018, Comprehensive Physiology.

[27]  G. Baay-Guzmán,et al.  Exercise Induces White Adipose Tissue Browning Across the Weight Spectrum in Humans , 2018, Front. Physiol..

[28]  T. Glumoff,et al.  Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes , 2018, Journal of Physiology and Biochemistry.

[29]  J. Dalley,et al.  Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue , 2018, Nature Communications.

[30]  T. Quesada-López,et al.  CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation. , 2018, Cell metabolism.

[31]  A. Carpentier,et al.  Brown Adipose Tissue Energy Metabolism in Humans , 2018, Front. Endocrinol..

[32]  Y. Jo,et al.  Intracellular glycolysis in brown adipose tissue is essential for optogenetically induced nonshivering thermogenesis in mice , 2018, Scientific Reports.

[33]  R. Zechner,et al.  Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation[S] , 2018, Journal of Lipid Research.

[34]  Frank B. Hu,et al.  Global aetiology and epidemiology of type 2 diabetes mellitus and its complications , 2018, Nature Reviews Endocrinology.

[35]  Y. Bao,et al.  Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat , 2018, Nature Communications.

[36]  N. Casals,et al.  Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice , 2017, Scientific Reports.

[37]  A. Eder,et al.  db/db Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL/6J Mice Fed a Western Diet , 2017, Journal of diabetes research.

[38]  C. Fernandes‐Santos,et al.  Ageing is associated with brown adipose tissue remodelling and loss of white fat browning in female C57BL/6 mice , 2017, International journal of experimental pathology.

[39]  S. Hébert,et al.  Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice , 2016, Neurobiology of Disease.

[40]  P. Pitule,et al.  Mitochondria in White, Brown, and Beige Adipocytes , 2016, Stem cells international.

[41]  T. Rolph,et al.  FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance , 2015, Scientific Reports.

[42]  Jiandie D. Lin,et al.  The brown fat secretome: metabolic functions beyond thermogenesis , 2015, Trends in Endocrinology & Metabolism.

[43]  M. Saito Brown Adipose Tissue as a Therapeutic Target for Obesity: From Mice to Humans , 2015 .

[44]  Zhimin Chen,et al.  The brown fat-enriched secreted factor Nrg 4 preserves metabolic homeostasis through attenuating hepatic lipogenesis , 2016 .

[45]  B. Spiegelman,et al.  Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis , 2014, Cell.

[46]  K. Walsh,et al.  Vascular rarefaction mediates whitening of brown fat in obesity. , 2014, The Journal of clinical investigation.

[47]  J. Jelsing,et al.  Characterisation of Age-Dependent Beta Cell Dynamics in the Male db/db Mice , 2013, PloS one.

[48]  B. Kingwell,et al.  Brown adipose tissue in humans: therapeutic potential to combat obesity. , 2013, Pharmacology & therapeutics.

[49]  F. Villarroya,et al.  BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions , 2012, Cell.

[50]  E. Ravussin,et al.  Brown adipose tissue and aging , 2011, Current opinion in clinical nutrition and metabolic care.

[51]  J. Vieira,et al.  Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals. , 2010, Arquivos de gastroenterologia.

[52]  M. Hur,et al.  Regulation of GLUT4 gene expression by SREBP-1c in adipocytes. , 2006, The Biochemical journal.

[53]  M. Akahane,et al.  Adiponectin receptor 2 expression in liver and insulin resistance in db/db mice given a beta3-adrenoceptor agonist. , 2005, European journal of pharmacology.

[54]  G. Shulman,et al.  Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver , 2001, Nature.

[55]  J. Pessin,et al.  Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). , 1995, The Journal of clinical investigation.