Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury

[1]  K. Lai,et al.  Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy , 2018, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[2]  Leslie S. Gewin,et al.  Renal fibrosis: Primacy of the proximal tubule. , 2018, Matrix biology : journal of the International Society for Matrix Biology.

[3]  Shuang Hu,et al.  miR-29b regulates Ang II-induced EMT of rat renal tubular epithelial cells via targeting PI3K/AKT signaling pathway. , 2018, International journal of molecular medicine.

[4]  Xiao-Feng Tang,et al.  Membrane rafts–redox signalling pathway contributes to renal fibrosis via modulation of the renal tubular epithelial–mesenchymal transition , 2018, The Journal of physiology.

[5]  Ying Li,et al.  Tranilast prevents renal interstitial fibrosis by blocking mast cell infiltration in a rat model of diabetic kidney disease. , 2018, Molecular medicine reports.

[6]  K. Ma,et al.  mROS-TXNIP axis activates NLRP3 inflammasome to mediate renal injury during ischemic AKI. , 2018, The international journal of biochemistry & cell biology.

[7]  I. L. Noronha,et al.  Acute Kidney Injury as a Condition of Renal Senescence , 2018, Cell transplantation.

[8]  H. Chung,et al.  Impairment of PPARα and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging. , 2018, Journal of the American Society of Nephrology : JASN.

[9]  K. Bernstein,et al.  Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy. , 2018, American journal of physiology. Renal physiology.

[10]  J. Nortier,et al.  CD4+ and CD8+ T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy , 2018, Scientific Reports.

[11]  R. Tan,et al.  Specific Inhibitor of Smad3 (SIS3) Attenuates Fibrosis, Apoptosis, and Inflammation in Unilateral Ureteral Obstruction Kidneys by Inhibition of Transforming Growth Factor β (TGF-β)/Smad3 Signaling , 2018, Medical science monitor : international medical journal of experimental and clinical research.

[12]  Mingjun Shi,et al.  Notch1 regulates PTEN expression to exacerbate renal tubulointerstitial fibrosis in diabetic nephropathy by inhibiting autophagy via interactions with Hes1. , 2018, Biochemical and biophysical research communications.

[13]  L. Lv,et al.  Renal tubule injury: a driving force toward chronic kidney disease. , 2018, Kidney international.

[14]  Yi Tang,et al.  TGF-β1/p53 signaling in renal fibrogenesis. , 2018, Cellular signalling.

[15]  J. Bonventre,et al.  Acute Kidney Injury and Progression of Diabetic Kidney Disease. , 2018, Advances in chronic kidney disease.

[16]  H. Aburatani,et al.  Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes , 2018, Scientific Reports.

[17]  L. Jin,et al.  Microvesicles containing microRNA-21 secreted by proximal tubular epithelial cells are involved in renal interstitial fibrosis by activating AKT pathway. , 2018, European review for medical and pharmacological sciences.

[18]  Leslie S. Gewin,et al.  Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe? , 2018, Genes.

[19]  Limin Liu,et al.  Hypoxia-induced activation of Twist/miR-214/E-cadherin axis promotes renal tubular epithelial cell mesenchymal transition and renal fibrosis. , 2018, Biochemical and biophysical research communications.

[20]  P. He,et al.  SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction , 2018, Molecular and Cellular Endocrinology.

[21]  Z. Ye,et al.  Uric acid upregulates the adiponectin-adiponectin receptor 1 pathway in renal proximal tubule epithelial cells , 2017, Molecular medicine reports.

[22]  Liping Huang,et al.  Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI. , 2017, Journal of the American Society of Nephrology : JASN.

[23]  S. K. Park,et al.  Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice , 2017, International journal of molecular medicine.

[24]  F-Q Li,et al.  FGF23 promotes renal interstitial fibrosis by activating β-catenin. , 2018, European review for medical and pharmacological sciences.

[25]  Scott R. Manson,et al.  Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease. , 2017, JCI insight.

[26]  Hui You,et al.  HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2α ubiquitylation and degradation , 2017, Cell Death & Disease.

[27]  P. Boor,et al.  Macrophage Migration Inhibitory Factor Limits Renal Inflammation and Fibrosis by Counteracting Tubular Cell Cycle Arrest. , 2017, Journal of the American Society of Nephrology : JASN.

[28]  J. He,et al.  Febuxostat attenuates ER stress mediated kidney injury in a rat model of hyperuricemic nephropathy , 2017, Oncotarget.

[29]  R. Geffers,et al.  Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1. , 2017, Kidney international.

[30]  D. Nikolic-Paterson,et al.  The JNK Signaling Pathway in Renal Fibrosis , 2017, Front. Physiol..

[31]  Linghong Huang,et al.  An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix , 2017, Biology Open.

[32]  F. Das,et al.  Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion. , 2017, American journal of physiology. Cell physiology.

[33]  O. Ichii,et al.  Local CD34-positive capillaries decrease in mouse models of kidney disease associating with the severity of glomerular and tubulointerstitial lesions , 2017, BMC Nephrology.

[34]  H. Duan,et al.  Sphingosine kinase 1 protects renal tubular epithelial cells from renal fibrosis via induction of autophagy. , 2017, The international journal of biochemistry & cell biology.

[35]  F. Das,et al.  PDGF receptor-β uses Akt/mTORC1 signaling node to promote high glucose-induced renal proximal tubular cell collagen I (α2) expression. , 2017, American journal of physiology. Renal physiology.

[36]  Ming Wang,et al.  Role of RAS/Wnt/β-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy. , 2017, Chemico-biological interactions.

[37]  Qing He,et al.  TRAP1 ameliorates renal tubulointerstitial fibrosis in mice with unilateral ureteral obstruction by protecting renal tubular epithelial cell mitochondria , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[38]  Ray Wilkinson,et al.  Interferon-γ production by tubulointerstitial human CD56bright natural killer cells contributes to renal fibrosis and chronic kidney disease progression. , 2017, Kidney international.

[39]  Jessica M. Overstreet,et al.  Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[40]  Edward R. Smith,et al.  FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts , 2017, Scientific Reports.

[41]  T. Hewitson,et al.  Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-β1 Stimulation , 2017, Front. Pharmacol..

[42]  Jie Huang,et al.  Atgl gene deletion predisposes to proximal tubule damage by impairing the fatty acid metabolism. , 2017, Biochemical and biophysical research communications.

[43]  K. Zen,et al.  UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury. , 2017, American journal of physiology. Renal physiology.

[44]  A. Webster,et al.  Chronic Kidney Disease , 2017, The Lancet.

[45]  Kyung Lee,et al.  The Role of Endoplasmic Reticulum Stress in Diabetic Nephropathy , 2017, Current Diabetes Reports.

[46]  H. Schnaper.  The Tubulointerstitial Pathophysiology of Progressive Kidney Disease. , 2017, Advances in chronic kidney disease.

[47]  R. Kramann,et al.  Gli1+ Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury. , 2017, Journal of the American Society of Nephrology : JASN.

[48]  J. Chun,et al.  Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor. , 2017, Kidney international.

[49]  A. Pozzi,et al.  Progression of chronic kidney disease: too much cellular talk causes damage. , 2017, Kidney international.

[50]  Y. Isaka,et al.  Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules , 2017, Diabetes.

[51]  J. Lambris,et al.  Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis. , 2017, American journal of physiology. Renal physiology.

[52]  Ai-hua Zhang,et al.  Retraction statement: ‘Urotensin II inhibits autophagy in renal tubular epithelial cells and induces extracellular matrix production in early diabetic mice’ by Guan‐Jong Chen, Fei Wu, Xin‐Xin Pang, Ai‐Hua Zhang, Jun‐Bao Shi, Min Lu and Chao‐Shu Tang , 2016, Journal of diabetes investigation.

[53]  Ming Wang,et al.  Title Role of RAS / Wnt / beta-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy , 2017 .

[54]  Tetsuhiro Tanaka.  A mechanistic link between renal ischemia and fibrosis , 2017, Medical Molecular Morphology.

[55]  Caixia Liu,et al.  Inhibition of p38 mitogen-activated protein kinases attenuates renal interstitial fibrosis in a murine unilateral ureteral occlusion model. , 2016, Life sciences.

[56]  Xiaoqiang Ding,et al.  Silencing HIF-1α aggravates growth inhibition and necrosis of proximal renal tubular epithelial cell under hypoxia , 2016, Renal failure.

[57]  S. Waikar,et al.  ADAM17 substrate release in proximal tubule drives kidney fibrosis. , 2016, JCI insight.

[58]  Soohong Min,et al.  The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis , 2016, Scientific Reports.

[59]  Shinya Yamamoto,et al.  Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis. , 2016, Journal of the American Society of Nephrology : JASN.

[60]  Scott R. Manson,et al.  Tubular Overexpression of Angiopoietin-1 Attenuates Renal Fibrosis , 2016, PloS one.

[61]  Huiyan Li,et al.  Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis , 2016, Autophagy.

[62]  P. Pennekamp,et al.  Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments. , 2016, Journal of the American Society of Nephrology : JASN.

[63]  Youhua Liu,et al.  Signaling Crosstalk between Tubular Epithelial Cells and Interstitial Fibroblasts after Kidney Injury , 2016, Kidney Diseases.

[64]  Bicheng Chen,et al.  Sonic hedgehog-mediated epithelial-mesenchymal transition in renal tubulointerstitial fibrosis. , 2016, International journal of molecular medicine.

[65]  Shuang Huang,et al.  Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction , 2016, Autophagy.

[66]  Xiangmei Chen,et al.  Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells , 2016, BMC Nephrology.

[67]  Yan Xu,et al.  Endoplasmic reticulum stress and its effects on renal tubular cells apoptosis in ischemic acute kidney injury , 2016, Renal failure.

[68]  Youhua Liu,et al.  Numb contributes to renal fibrosis by promoting tubular epithelial cell cycle arrest at G2/M , 2016, Oncotarget.

[69]  E. Bottinger,et al.  Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI. , 2016, Journal of the American Society of Nephrology : JASN.

[70]  Jenq-Wen Huang,et al.  Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro , 2016, Oncotarget.

[71]  R. Kramann,et al.  Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk. , 2016, Journal of the American Society of Nephrology : JASN.

[72]  G. Gamba,et al.  AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease. , 2016, Kidney international.

[73]  Quanyou Gong,et al.  Silencing of angiotensin II type-1 receptor inhibits high glucose-induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells via inactivation of mTOR/p70S6K signaling pathway. , 2016, Biochemical and biophysical research communications.

[74]  Jian-wei Tian,et al.  MicroRNA-130b improves renal tubulointerstitial fibrosis via repression of Snail-induced epithelial-mesenchymal transition in diabetic nephropathy , 2015, Scientific Reports.

[75]  J. Schelling.  Tubular atrophy in the pathogenesis of chronic kidney disease progression , 2016, Pediatric Nephrology.

[76]  G. Wolf,et al.  Epithelial-to-Mesenchymal Transition in Diabetic Nephropathy: Fact or Fiction? , 2015, Cells.

[77]  G. Kaushal,et al.  Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury , 2015, PloS one.

[78]  R. Kalluri,et al.  Epithelial to Mesenchymal Transition induces cell cycle arrest and parenchymal damage in renal fibrosis , 2015, Nature Medicine.

[79]  Ting-ting Guo,et al.  ATF6 pathway of unfolded protein response mediates advanced oxidation protein product-induced hypertrophy and epithelial-to-mesenchymal transition in HK-2 cells , 2015, Molecular and Cellular Biochemistry.

[80]  Se-Yun Kim,et al.  Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy. , 2015, American journal of physiology. Renal physiology.

[81]  J. Bonventre,et al.  Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD , 2015, Nature Reviews Nephrology.

[82]  Zhanjun Jia,et al.  Mitochondrial dysfunction confers albumin-induced NLRP3 inflammasome activation and renal tubular injury. , 2015, American journal of physiology. Renal physiology.

[83]  P. Boor,et al.  Renal Allograft Fibrosis: Biology and Therapeutic Targets , 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[84]  Jun Li,et al.  TGF-β/Smad signaling in renal fibrosis , 2015, Front. Physiol..

[85]  S. Yagi,et al.  Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney. , 2015, Journal of the American Society of Nephrology : JASN.

[86]  Kumar Sharma,et al.  Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development , 2014, Nature Medicine.

[87]  Tsutomu Inoue,et al.  The contribution of epithelial-mesenchymal transition to renal fibrosis differs among kidney disease models. , 2015, Kidney international.

[88]  K. Ma,et al.  Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: a novel mechanism of albumin-induced tubulointerstitial inflammation. , 2014, The international journal of biochemistry & cell biology.

[89]  E. Rondeau,et al.  Expression of the transcriptional regulator snail1 in kidney transplants displaying epithelial-to-mesenchymal transition features. , 2014, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[90]  A. Djamali,et al.  The role of complement in the pathogenesis of renal ischemia-reperfusion injury and fibrosis , 2014, Fibrogenesis & tissue repair.

[91]  J. Bonventre.  Primary proximal tubule injury leads to epithelial cell cycle arrest, fibrosis, vascular rarefaction, and glomerulosclerosis , 2014, Kidney international supplements.

[92]  K. Zen,et al.  Secreted fibroblast-derived miR-34a induces tubular cell apoptosis in fibrotic kidney , 2014, Journal of Cell Science.

[93]  D. Medici,et al.  Signaling mechanisms of the epithelial-mesenchymal transition , 2014, Science Signaling.

[94]  J. Bonventre.  Maladaptive Proximal Tubule Repair: Cell Cycle Arrest , 2014, Nephron Clinical Practice.

[95]  Limin Liu,et al.  Hypoxia-induced Bmi1 promotes renal tubular epithelial cell–mesenchymal transition and renal fibrosis via PI3K/Akt signal , 2014, Molecular biology of the cell.

[96]  Esther W. Gomez,et al.  Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer , 2014, Clinical and Translational Medicine.

[97]  A. Bennaceur-Griscelli,et al.  Amniotic Fluid‐Derived Mesenchymal Stem Cells Prevent Fibrosis and Preserve Renal Function in a Preclinical Porcine Model of Kidney Transplantation , 2014, Stem cells translational medicine.

[98]  M. Haas.  Chronic allograft nephropathy or interstitial fibrosis and tubular atrophy: what is in a name? , 2014, Current opinion in nephrology and hypertension.

[99]  Robert H. Jenkins,et al.  miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. , 2014, The American journal of pathology.

[100]  M. Coughlan,et al.  Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy? , 2014, British journal of pharmacology.

[101]  J. D. de Fijter,et al.  Mesenchymal stromal cells to prevent fibrosis in kidney transplantation , 2014, Current opinion in organ transplantation.

[102]  R. Dua,et al.  Hypoxia-induced Bmi 1 promotes renal tubular epithelial cell – mesenchymal transition and renal fibrosis via PI 3 K / Akt signal , 2014 .

[103]  C. Paz,et al.  Modulation of albumin-induced endoplasmic reticulum stress in renal proximal tubule cells by upregulation of mapk phosphatase-1. , 2013, Chemico-biological interactions.

[104]  T. Uzu,et al.  Altered unfolded protein response is implicated in the age-related exacerbation of proteinuria-induced proximal tubular cell damage. , 2013, The American journal of pathology.

[105]  J. Megyesi,et al.  Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction. , 2013, American journal of physiology. Renal physiology.

[106]  S. Ledbetter,et al.  Increased Cellular Senescence and Vascular Rarefaction Exacerbate the Progression of Kidney Fibrosis in Aged Mice Following Transient Ischemic Injury , 2013, PloS one.

[107]  E. Rondeau,et al.  Epithelial phenotypic changes are associated with a tubular active fibrogenic process in human renal grafts. , 2013, Human pathology.

[108]  S. Zhuang,et al.  Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury. , 2013, The American journal of pathology.

[109]  S. Alexander,et al.  Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage , 2013, Laboratory Investigation.

[110]  S. Zhuang,et al.  Blocking the Class I Histone Deacetylase Ameliorates Renal Fibrosis and Inhibits Renal Fibroblast Activation via Modulating TGF-Beta and EGFR Signaling , 2013, PloS one.

[111]  N. Lloberas,et al.  Mesenchymal stem cell therapy prevents interstitial fibrosis and tubular atrophy in a rat kidney allograft model. , 2012, Stem cells and development.

[112]  Kanako Yanagida,et al.  Advanced Glycation Endproducts Stimulate Renal Epithelial Cells to Release Chemokines That Recruit Macrophages, Leading to Renal Fibrosis , 2012, Bioscience, biotechnology, and biochemistry.

[113]  Hanmin Wang,et al.  Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells , 2012, PloS one.

[114]  Josef Coresh,et al.  Chronic kidney disease , 2012, The Lancet.

[115]  Youhua Liu.  Cellular and molecular mechanisms of renal fibrosis , 2011, Nature Reviews Nephrology.

[116]  Rong Wang,et al.  The Role of the p38 MAPK Signaling Pathway in High Glucose-Induced Epithelial-Mesenchymal Transition of Cultured Human Renal Tubular Epithelial Cells , 2011, PloS one.

[117]  V. Demarco,et al.  Angiotensin II Activation of mTOR Results in Tubulointerstitial Fibrosis through Loss of N-Cadherin , 2011, American Journal of Nephrology.

[118]  J. Bonventre,et al.  Pathophysiology of acute kidney injury to chronic kidney disease: maladaptive repair. , 2011, Contributions to nephrology.

[119]  J. Duffield,et al.  Resolved: EMT produces fibroblasts in the kidney. , 2010, Journal of the American Society of Nephrology : JASN.

[120]  Youhua Liu.  New insights into epithelial-mesenchymal transition in kidney fibrosis. , 2010, Journal of the American Society of Nephrology : JASN.

[121]  A. McMahon,et al.  Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. , 2010, The American journal of pathology.

[122]  Raghu Kalluri,et al.  The basics of epithelial-mesenchymal transition. , 2009, The Journal of clinical investigation.

[123]  N. Brousse,et al.  Early epithelial phenotypic changes predict graft fibrosis. , 2008, Journal of the American Society of Nephrology : JASN.

[124]  R. Gilbert,et al.  High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanism. , 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[125]  P. Fisher,et al.  Cell cycle arrest. , 1995, Science.