CORRELATION OF HISTOMORPHOLOGICAL PARAMETERS AS BIOMARKERS OF CERVICAL LYMPH NODE METASTASIS IN ORAL SQUAMOUS CELL CARCINOMA: A PROSPECTIVE STUDY

Background: Histopathological parameters markers as potential predictive factors for LN metastasis. Objective: The study is designed to compare various histomorphological factors in Oral Squamous Cell Carcinoma with respect to Lymph Node metastasis. Materials and methods: A prospective, comparative study conducted at Bhagwan Mahaveer Cancer Hospital and Research Center Jaipur. Data regarding the histomorphological parameter were analyzed. Results: 100 cases of of oral squamous cell carcinoma were analyzed in present study.. Most common site for oral squamous cell carcinoma in this study was buccal mucosa in 62% of cases. In present study, of the total 79 cases with Grade 1 degree of differentiation, 31 cases had LN metastasis while 42 cases were negative for LN involvement. Out of 100 patients, 43 cases showed PNI while in 57 cases PNI was absent and 41 cases showed LVI while in 59 cases LVI was absent. Among 100 cases, 22 cases had marked lymphocytic response, 69 cases lymphocytic response was moderate while in 9 cases it was mild lymphocytic response. pattern comprising of WPOI IV& Vwere 31 and 45 respectively. Conclusion: Buccal mucosa was the commonest subsite of origin of primary carcinoma in the oral cavity and size of primary tumor did not affect the rate of cervical lymph node metastasis.

[1]  Anand Gupta,et al.  Tumor Budding and Worse Pattern of Invasion Can Predict Nodal Metastasis in Oral Cancers and Associated With Poor Survival in Early-Stage Tumors , 2019, Ear, nose, & throat journal.

[2]  N. Hedne,et al.  Correlation between histological grading, LVI and PNI of carcinoma oral tongue to lymph node metastasis , 2018, International Journal of Otorhinolaryngology and Head and Neck Surgery.

[3]  A. Samaranayaka,et al.  A model to predict nodal metastasis in patients with oral squamous cell carcinoma , 2018, PloS one.

[4]  H. Hiratsuka,et al.  Tumor budding is an independent prognostic marker in early stage oral squamous cell carcinoma: With special reference to the mode of invasion and worst pattern of invasion , 2018, PloS one.

[5]  S. Warnakulasuriya.  Global epidemiology of oral and oropharyngeal cancer. , 2009, Oral oncology.

[6]  Artur Ferreira,et al.  Oral squamous cell carcinoma: review of prognostic and predictive factors. , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[7]  J. Woolgar.  Pathology of the N0 neck. , 1999, The British journal of oral & maxillofacial surgery.

[8]  R A Greenberg,et al.  Thickness as prognostic aid in upper aerodigestive tract cancer. , 1986, Archives of surgery.

[9]  A. Leonard,et al.  Correlation between prognosis and degree of lymph node involvement in carcinoma of the oral cavity , 1977 .

[10]  T. Suresh,et al.  Evaluation of histomorphological and immunohistochemical parameters as biomarkers of cervical lymph node metastasis in squamous cell carcinoma of oral cavity: A retrospective study , 2015, Journal of oral and maxillofacial pathology : JOMFP.

[11]  R M Byers,et al.  Rationale for elective modified neck dissection. , 1988, Head & neck surgery.