HPLC Determination of Entecavir in Pure , Tablet Dosage Form and Spiked Plasma

1 Muhammad Ashraf*, 2 Hafiz Muhammad Nauman Shabbir, 2 Muhammad Munawar Hayat, 1 Jameel Rahman, 3 Samina Ejaz, 3 Muhammad Iqbal, and 1 Faiz-ul-Hassan Nasim Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. Department of Biochemistry & Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan. dr.m.ashraf@gmail.com*

[1]  J. Chen,et al.  Bioequivalence Evaluation of 2 Tablet Formulations of Entecavir in Healthy Chinese Volunteers: A Single-Dose, Randomized-Sequence, Open-Label Crossover Study , 2012, Arzneimittelforschung/Drug Research.

[2]  B. Chandu,et al.  LC-ESI-MS/MS method for the quantification of entecavir in human plasma and its application to bioequivalence study. , 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[3]  D. R. Nogueira,et al.  Development and validation of a stability-indicating capillary zone electrophoretic method for the assessment of entecavir and its correlation with liquid chromatographic methods. , 2011, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[4]  P. Subrahmanyam,et al.  Novel Spectrophotometric Methods For The Determination Of Entecavir In Pharmaceutical Dosage Forms , 2011 .

[5]  D. R. Nogueira,et al.  Validation of a stability-indicating RP-HPLC method for the determination of entecavir in tablet dosage form. , 2010, Journal of AOAC International.

[6]  J. Gale,et al.  A sensitive method for the determination of entecavir at picogram per milliliter level in human plasma by solid phase extraction and high-pH LC-MS/MS. , 2009, Journal of pharmaceutical and biomedical analysis.

[7]  H. Van Vlierberghe,et al.  Entecavir is superior to lamivudine in reducing hepatitis B virus DNA in patients with chronic hepatitis B infection. , 2002, Gastroenterology.

[8]  L. Corey,et al.  Long-term entecavir treatment results in sustained antiviral efficacy and prolonged life span in the woodchuck model of chronic hepatitis infection. , 2001, The Journal of infectious diseases.