Chemical Reaction Retrieval Using Citation-Based Relationships

It has been reported that a novel method for retrieving reactions similar to a given query reaction is to use relationships created by literature citations. Later publications citing a new reaction are likely to contain pertinent information about related reactions. In this study of all citing papers to 50 new synthetic methods indexed in Current Chemical Reactions, approximately half of the papers found by cited reference searching would not have been retrieved with reaction or substructure search approaches.