Pharmacological GLUT3 salvage augments the efficacy of vitamin C-induced TET2 restoration in acute myeloid leukemia

[1]  R. Shiekhattar,et al.  Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia , 2023, Cell reports.

[2]  B. Manavathi,et al.  AMPK: An odyssey of a metabolic regulator, a tumor suppressor, and now a contextual oncogene. , 2022, Biochimica et biophysica acta. Reviews on cancer.

[3]  M. Voso,et al.  Vitamin C Deficiency in Patients With Acute Myeloid Leukemia , 2022, Frontiers in Oncology.

[4]  M. Hampton,et al.  Ascorbate Inhibits Proliferation and Promotes Myeloid Differentiation in TP53-Mutant Leukemia , 2021, Frontiers in Oncology.

[5]  H. Lalić,et al.  AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review , 2021, Cells.

[6]  L. Nováková,et al.  Vitamin C—Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination , 2021, Nutrients.

[7]  J. Qin,et al.  GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies , 2020, Signal Transduction and Targeted Therapy.

[8]  Junshik Hong,et al.  Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restoration , 2020, British Journal of Cancer.

[9]  M. Chorilli,et al.  Vitamin c: One compound, several uses. Advances for delivery, efficiency and stability. , 2020, Nanomedicine : nanotechnology, biology, and medicine.

[10]  M. Nicolas,et al.  Acadesine Circumvents Azacitidine Resistance in Myelodysplastic Syndrome and Acute Myeloid Leukemia , 2019, International journal of molecular sciences.

[11]  Eric Song,et al.  ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses , 2018, Proceedings of the National Academy of Sciences.

[12]  Fei Lan,et al.  Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer , 2018, Nature.

[13]  N. Cabezas-Wallscheid,et al.  Vitamin C: C-ing a New Way to Fight Leukemia. , 2017, Cell stem cell.

[14]  O. Abdel-Wahab,et al.  Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression , 2017, Cell.

[15]  R. Deberardinis,et al.  Ascorbate regulates haematopoietic stem cell function and leukaemogenesis , 2017, Nature.

[16]  Saijuan Chen,et al.  Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential. , 2016, Cancer cell.

[17]  Peter A. Jones,et al.  Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine , 2016, Proceedings of the National Academy of Sciences.

[18]  L. Notarangelo,et al.  Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency , 2016, Science Translational Medicine.

[19]  K. Helin,et al.  Role of TET enzymes in DNA methylation, development, and cancer , 2016, Genes & development.

[20]  O. Bernard,et al.  TET proteins and the control of cytosine demethylation in cancer , 2015, Genome Medicine.

[21]  R. Winn,et al.  The soft agar colony formation assay. , 2014, Journal of visualized experiments : JoVE.

[22]  D. Douer,et al.  Adding ascorbic acid to arsenic trioxide produces limited benefit in patients with acute myeloid leukemia excluding acute promyelocytic leukemia , 2014, Annals of Hematology.

[23]  I. Lossos,et al.  Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas , 2014, Nature Genetics.

[24]  C Haferlach,et al.  Landscape of genetic lesions in 944 patients with myelodysplastic syndromes , 2013, Leukemia.

[25]  Zechen Chong,et al.  Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. , 2013, Journal of the American Chemical Society.

[26]  William A. Pastor,et al.  TETonic shift: biological roles of TET proteins in DNA demethylation and transcription , 2013, Nature Reviews Molecular Cell Biology.

[27]  E. González-Barca,et al.  Acadesine for patients with relapsed/refractory chronic lymphocytic leukemia (CLL): a multicenter phase I/II study , 2012, Cancer Chemotherapy and Pharmacology.

[28]  B. Halliwell.  Vitamin C: antioxidant or pro-oxidant in vivo? , 1996, Free radical research.