High insulin levels do not influence PC‐1 gene expression and protein content in human muscle tissue and hepatoma cells

To verify whether insulin levels influence PC‐1 tissue content, we studied PC‐1 gene expression and protein content in skeletal muscle of patients with insulinoma, a model of primary hyperinsulinemia. Data were compared with those obtained in matched insulin sensitive or resistant healthy subjects. In addition, the effect of high insulin concentration on PC‐1 protein content was studied in HepG2 cells.

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