Nanotechnology has emerged as the most innovative and revolutionary scientific field in decades that deals with matter in the range of nanoscale (1–100 nm). These nanoscale materials, commonly called as nanoparticles (NPs), exhibit unique physical, chemical and biological properties. The great potential of NPs has been explored to a large extent in multifarious fields such as medical, electronics, cosmetics and environmental remediation for societal benefits. However, the full potential of nanotechnology in agricultural sector is still budding and yet to be explored. After unsustainable approach of green revolution, recently nanoparticles based strategy is gaining considerable attention in agriculture owing to its unique properties, as compared to biopesticides leading to nano-revolution for maintaining sustainability in agriculture. Undoubtedly, nanotechnology in agriculture is the unexplored area which is expected to expand in the coming years. Besides expecting excellent applications of nanotechnology in agriculture, there are some biosafety issues which need to be addressed in future research endeavor. In this regard, the present review deals with both opportunities and constraints of nanotechnological applications in agriculture.