Magnetic resonance imaging measurement of volume magnetic susceptibility using a boundary condition.

A magnetic resonance imaging method is described for measuring the magnetic susceptibility difference between two homogeneous macroscopic compartments in contact with each other. A boundary condition is derived for the interface of the two compartments. This boundary condition predicts that across the interface there is a resonant frequency jump, which is a function of interfacial orientation relative to B0 field and the difference in susceptibility of the two sides. Based on this relationship, the magnetic susceptibility difference between two materials can be obtained from MR gradient echo imaging using signals from both sides in the vicinity of the boundary. This method is demonstrated by solution phantom experiments.

[1]  P J Diaz,et al.  MR susceptometry: an external‐phantom method for measuring bulk susceptibility from field‐echo phase reconstruction maps , 1994, Journal of magnetic resonance imaging : JMRI.

[2]  C. Springer,et al.  Bulk magnetic susceptibility shifts in nmr studies of compartmentalized samples: use of paramagnetic reagents , 1990, Magnetic resonance in medicine.

[3]  Robert J. Gillies,et al.  NMR in physiology and biomedicine , 1994 .

[4]  G H Glover,et al.  Three‐point dixon technique for true water/fat decomposition with B0 inhomogeneity correction , 1991, Magnetic resonance in medicine.

[5]  C. Slichter.  Principles of magnetic resonance , 1963 .

[6]  J. Tripp,et al.  Magnetic-susceptibility measurement of human iron stores. , 1982, The New England journal of medicine.

[7]  O Beuf,et al.  Magnetic resonance imaging for the determination of magnetic susceptibility of materials. , 1996, Journal of magnetic resonance. Series B.

[8]  R. Weisskoff,et al.  MRI susceptometry: Image‐based measurement of absolute susceptibility of MR contrast agents and human blood , 1992, Magnetic resonance in medicine.

[9]  T J Mosher,et al.  Magnetic susceptibility measurement using a double‐DANTE tagging (DDT) sequence , 1991, Magnetic resonance in medicine.

[10]  D. A. Dunnett.  Classical Electrodynamics , 2020, Nature.

[11]  D W Kormos,et al.  Separation of true fat and water images by correcting magnetic field inhomogeneity in situ. , 1986, Radiology.

[12]  W. Roberts,et al.  Iron in the heart. Etiology and clinical significance. , 1971, The American journal of medicine.

[13]  J H Bauman,et al.  Estimation of hepatic iron stores by vivo measurement of magnetic susceptibility. , 1967, The Journal of laboratory and clinical medicine.

[14]  C. S. Springer,et al.  Physicochemical Principles Influencing Magnetopharmaceuticals , 1994 .

[15]  Richter Gw.  The iron-loaded cell--the cytopathology of iron storage. A review. , 1978 .