Severe Asthma in Children: Lessons Learned and Future Directions

[1]  A. Fitzpatrick,et al.  Cysteine oxidation impairs systemic glucocorticoid responsiveness in children with difficult-to-treat asthma. , 2015, The Journal of allergy and clinical immunology.

[2]  J. McDunn,et al.  Metabolomic Endotype of Asthma , 2015, The Journal of Immunology.

[3]  L. Bacharier,et al.  Severe Asthma in School-Age Children: Evaluation and Phenotypic Advances , 2015, Current Allergy and Asthma Reports.

[4]  E. Bleecker,et al.  Obstructive Sleep Apnea Risk, Asthma Burden, and Lower Airway Inflammation in Adults in the Severe Asthma Research Program (SARP) II. , 2015, The journal of allergy and clinical immunology. In practice.

[5]  E. Bleecker,et al.  Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40. , 2015, The Journal of allergy and clinical immunology.

[6]  A. Fitzpatrick,et al.  Characterization of a high TNF-α phenotype in children with moderate-to-severe asthma. , 2015, The Journal of allergy and clinical immunology.

[7]  W. Busse,et al.  Erratum. Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity. , 2015, The European respiratory journal.

[8]  S. Hazen,et al.  Biomarker-based asthma phenotypes of corticosteroid response. , 2015, The Journal of allergy and clinical immunology.

[9]  P. Nietert,et al.  Identification of Asthma Phenotypes in a Tertiary Care Medical Center , 2014, The American journal of the medical sciences.

[10]  F. Virant.  Cotinine in Children Admitted for Asthma and Readmission , 2014, Pediatrics.

[11]  P. Chanez,et al.  Prognostic value of cluster analysis of severe asthma phenotypes. , 2014, The Journal of allergy and clinical immunology.

[12]  W. Busse,et al.  Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity , 2014, European Respiratory Journal.

[13]  Ziv Bar-Joseph,et al.  Gene expression in relation to exhaled nitric oxide identifies novel asthma phenotypes with unique biomolecular pathways. , 2014, American journal of respiratory and critical care medicine.

[14]  E. Hoffman,et al.  Longitudinal changes in airway remodeling and air trapping in severe asthma. , 2014, Academic radiology.

[15]  H. Grönlund,et al.  Prevalence of severe childhood asthma according to the WHO. , 2014, Respiratory medicine.

[16]  W. Busse,et al.  Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. , 2014, The Journal of allergy and clinical immunology.

[17]  M. Schatz,et al.  Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma. , 2014, The Journal of allergy and clinical immunology.

[18]  Kuo-Chin Huang,et al.  Pathway from central obesity to childhood asthma. Physical fitness and sedentary time are leading factors. , 2014, American journal of respiratory and critical care medicine.

[19]  D. Curran‐Everett,et al.  Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. , 2014, The Journal of allergy and clinical immunology.

[20]  S. Weiss,et al.  Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications. , 2014, The Journal of allergy and clinical immunology.

[21]  I. Momas,et al.  Childhood allergic asthma is not a single phenotype. , 2014, The Journal of pediatrics.

[22]  W. Busse,et al.  Characterization of factors associated with systemic corticosteroid use in severe asthma: data from the Severe Asthma Research Program. , 2014, The Journal of allergy and clinical immunology.

[23]  M. Gladwin,et al.  An Airway Epithelial iNOS-DUOX2-Thyroid Peroxidase Metabolome Drives Th1/Th2 Nitrative Stress in Human Severe Asthma , 2014, Mucosal Immunology.

[24]  C. D. Page,et al.  Childhood asthma clusters and response to therapy in clinical trials. , 2014, The Journal of allergy and clinical immunology.

[25]  Dean P. Jones,et al.  Children with severe asthma have unique oxidative stress-associated metabolomic profiles. , 2013, The Journal of allergy and clinical immunology.

[26]  E. Bleecker,et al.  International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma , 2013, European Respiratory Journal.

[27]  E. Bleecker,et al.  Clinical heterogeneity in the severe asthma research program. , 2013, Annals of the American Thoracic Society.

[28]  S. Sullivan,et al.  Trends in cost and outcomes among adult and pediatric patients with asthma: 2000-2009. , 2013, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[29]  Alan E. Simon,et al.  Impact of environmental tobacco smoke on children with asthma, United States, 2003-2010. , 2013, Academic pediatrics.

[30]  W. Busse,et al.  Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. , 2013, The Journal of allergy and clinical immunology.

[31]  Stanley J Kruger,et al.  Markers of vascular perturbation correlate with airway structural change in asthma. , 2013, American journal of respiratory and critical care medicine.

[32]  W. Busse,et al.  Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the Severe Asthma Research Program. , 2013, Chest.

[33]  Christopher R. Gignoux,et al.  A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. , 2013, The Journal of allergy and clinical immunology.

[34]  Alan E. Simon,et al.  US Prevalence and Trends in Tobacco Smoke Exposure Among Children and Adolescents With Asthma , 2013, Pediatrics.

[35]  W. Busse,et al.  An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. , 2013, American journal of respiratory and critical care medicine.

[36]  W. Busse,et al.  Sleep quality and asthma control and quality of life in non-severe and severe asthma , 2012, Sleep and Breathing.

[37]  L. Akinbami,et al.  National surveillance of asthma: United States, 2001-2010. , 2012, Vital & health statistics. Series 3, Analytical and epidemiological studies.

[38]  W. Busse,et al.  Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. , 2012, The Journal of allergy and clinical immunology.

[39]  Y. Shao,et al.  Application of the Asthma Phenotype Algorithm from the Severe Asthma Research Program to an Urban Population , 2012, PloS one.

[40]  S. Wenzel,et al.  Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset , 2012, Thorax.

[41]  Christopher R. Gignoux,et al.  Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects. , 2012, The Journal of allergy and clinical immunology.

[42]  W. Busse,et al.  The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma. , 2012, The Journal of allergy and clinical immunology.

[43]  Tonya S. King,et al.  Cluster Analysis of Obesity and Asthma Phenotypes , 2012, PloS one.

[44]  Robert A Silverman,et al.  Effect of asthma exacerbations on health care costs among asthmatic patients with moderate and severe persistent asthma. , 2012, The Journal of allergy and clinical immunology.

[45]  A. Bush,et al.  Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines. , 2012, The Journal of allergy and clinical immunology.

[46]  Mario Castro,et al.  Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. , 2012, American journal of respiratory and critical care medicine.

[47]  A. Fitzpatrick,et al.  Airway TGF-β1 and oxidant stress in children with severe asthma: association with airflow limitation. , 2012, The Journal of allergy and clinical immunology.

[48]  W. Busse,et al.  The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients. , 2012, The Journal of allergy and clinical immunology.

[49]  I. Annesi-Maesano,et al.  Two novel, severe asthma phenotypes identified during childhood using a clustering approach , 2012, European Respiratory Journal.

[50]  W. Busse,et al.  Safety of investigative bronchoscopy in the Severe Asthma Research Program. , 2011, The Journal of allergy and clinical immunology.

[51]  S. Szefler,et al.  Economic burden of impairment in children with severe or difficult-to-treat asthma. , 2011, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[52]  Ryan D. Hernandez,et al.  Meta-analysis of Genome-wide Association Studies of Asthma In Ethnically Diverse North American Populations , 2011, Nature Genetics.

[53]  W. Busse,et al.  Importance of hedgehog interacting protein and other lung function genes in asthma. , 2011, The Journal of allergy and clinical immunology.

[54]  Dean P. Jones,et al.  Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2. , 2011, The Journal of allergy and clinical immunology.

[55]  W. Busse,et al.  Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity , 2011, PloS one.

[56]  W. Busse,et al.  Obesity and asthma: an association modified by age of asthma onset. , 2011, The Journal of allergy and clinical immunology.

[57]  A. Fitzpatrick,et al.  Sex dependence of airflow limitation and air trapping in children with severe asthma. , 2011, The Journal of allergy and clinical immunology.

[58]  Mario Castro,et al.  Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. , 2011, The Journal of allergy and clinical immunology.

[59]  W. Busse,et al.  Determinants of exhaled breath condensate pH in a large population with asthma. , 2011, Chest.

[60]  D. Laskowski,et al.  Glutathione Oxidation Is Associated With Airway Macrophage Functional Impairment in Children With Severe Asthma , 2011, Pediatric Research.

[61]  Adnan Custovic,et al.  Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. , 2011, The Journal of allergy and clinical immunology.

[62]  W. Busse,et al.  Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program. , 2011, American journal of respiratory and critical care medicine.

[63]  D. Jarvis,et al.  Identifying adult asthma phenotypes using a clustering approach , 2011, European Respiratory Journal.

[64]  W. Busse,et al.  Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program. , 2010, The Journal of allergy and clinical immunology.

[65]  Martyn R Partridge,et al.  Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. , 2010, The Journal of allergy and clinical immunology.

[66]  Mario Castro,et al.  Predicting Intermediate Phenotypes in Asthma Using Bronchoalveolar Lavage‐Derived Cytokines , 2010, Clinical and translational science.

[67]  S. Erzurum,et al.  Breath Formate Is a Marker of Airway S-Nitrosothiol Depletion in Severe Asthma , 2010, PloS one.

[68]  W. Busse,et al.  Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. , 2010, American journal of respiratory and critical care medicine.

[69]  Deborah A Meyers,et al.  Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. , 2010, The Journal of allergy and clinical immunology.

[70]  A. Fitzpatrick,et al.  The molecular phenotype of severe asthma in children. , 2010, The Journal of allergy and clinical immunology.

[71]  A. Fitzpatrick,et al.  Obesity, asthma, and oxidative stress. , 2010, Journal of applied physiology.

[72]  D. Curran‐Everett,et al.  Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. , 2010, American journal of respiratory and critical care medicine.

[73]  A. Jackson,et al.  A Deep Breath Bronchoconstricts Obese Asthmatics , 2010, The Journal of asthma : official journal of the Association for the Care of Asthma.

[74]  A. Fitzpatrick,et al.  Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma. , 2009, The Journal of allergy and clinical immunology.

[75]  D. Laskowski,et al.  Effects of the menstrual cycle on lung function variables in women with asthma. , 2009, American journal of respiratory and critical care medicine.

[76]  M. Weatherall,et al.  Distinct clinical phenotypes of airways disease defined by cluster analysis , 2009, European Respiratory Journal.

[77]  E. Israel,et al.  Noninvasive Markers of Airway Inflammation in Asthma , 2009, Clinical and translational science.

[78]  Jie Zheng,et al.  Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology. , 2008, Chest.

[79]  W. Busse,et al.  Alterations of the arginine metabolome in asthma. , 2008, American journal of respiratory and critical care medicine.

[80]  Mike Thomas,et al.  Cluster analysis and clinical asthma phenotypes. , 2008, American journal of respiratory and critical care medicine.

[81]  A. Fitzpatrick,et al.  Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma. , 2008, The Journal of allergy and clinical immunology.

[82]  W. Busse,et al.  Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. , 2008, Journal of applied physiology.

[83]  K. Schechtman,et al.  Epithelial cell proliferation contributes to airway remodeling in severe asthma. , 2007, American journal of respiratory and critical care medicine.

[84]  D. Curran‐Everett,et al.  Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. , 2007, The Journal of allergy and clinical immunology.

[85]  S. Erzurum,et al.  Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxide. , 2006, The Journal of allergy and clinical immunology.

[86]  S. Erzurum,et al.  Buffering airway acid decreases exhaled nitric oxide in asthma. , 2006, The Journal of allergy and clinical immunology.

[87]  S. Hazen,et al.  Nitrotyrosine Proteome Survey in Asthma Identifies Oxidative Mechanism of Catalase Inactivation1 , 2006, The Journal of Immunology.

[88]  L. Palmer,et al.  Diminished lipoxin biosynthesis in severe asthma. , 2005, American journal of respiratory and critical care medicine.

[89]  W. Busse,et al.  Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. , 2005, American journal of respiratory and critical care medicine.

[90]  Third Expert Panel on theDiagnosis,et al.  Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma , 1997 .

[91]  L. Bacharier,et al.  Severe Asthma in Children. , 2017, The journal of allergy and clinical immunology. In practice.

[92]  Hollis G. Potter,et al.  Author Manuscript , 2013 .

[93]  A. Fitzpatrick,et al.  Poor asthma control in obese children may be overestimated because of enhanced perception of dyspnea. , 2013, The journal of allergy and clinical immunology. In practice.

[94]  T. Nurmagambetov,et al.  Costs of asthma in the United States: 2002-2007. , 2011, The Journal of allergy and clinical immunology.

[95]  A. Fitzpatrick,et al.  Progressive airflow limitation is a feature of children with severe asthma. , 2011, The Journal of allergy and clinical immunology.

[96]  Jeannine S. Schiller,et al.  Early release of selected estimates based on data from the January-March 2011 National Health Interview Survey , 2011 .

[97]  A. Fitzpatrick,et al.  Severe Asthma in Children: Insights from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. , 2010, Pediatric allergy, immunology, and pulmonology.

[98]  Fernando Holguin,et al.  Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress. , 2009, The Journal of allergy and clinical immunology.

[99]  Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. , 2007, The Journal of allergy and clinical immunology.

[100]  S. Spector,et al.  Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society. , 2000, American journal of respiratory and critical care medicine.