Alterations of BDNF, mGluR5, Homer1a, p11 and excitatory/inhibitory balance in corticolimbic brain regions of suicide decedents.

[1]  De-xiang Liu,et al.  Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats , 2023, Psychopharmacology.

[2]  M. Ali,et al.  Antidepressant and anti-suicidal effects of ketamine in treatment-resistant depression associated with psychiatric and personality comorbidities: A double-blind randomized trial. , 2023, Journal of affective disorders.

[3]  A. Rosa,et al.  Differentially regulated targets in the fast-acting antidepressant effect of (R)-ketamine: A systems biology approach , 2023, Pharmacology Biochemistry and Behavior.

[4]  Y. Oh,et al.  S100A10 and its binding partners in depression and antidepressant actions , 2022, Frontiers in Molecular Neuroscience.

[5]  Yonggui Yuan,et al.  The interaction of P11 methylation and early-life stress impacts the antidepressant response in patients with major depressive disorder. , 2022, Journal of affective disorders.

[6]  P. Verhaert,et al.  Hippocampal neuropathology in suicide: Gaps in our knowledge and opportunities for a breakthrough , 2021, Neuroscience & Biobehavioral Reviews.

[7]  P. Masand,et al.  Ketamine for treatment of mood disorders and suicidality: A narrative review of recent progress. , 2021, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

[8]  J. Mann,et al.  The rapid anti-suicidal ideation effect of ketamine: A systematic review. , 2021, Preventive medicine.

[9]  P. Svenningsson,et al.  Ketamine decreases neuronally released glutamate via retrograde stimulation of presynaptic adenosine A1 receptors , 2021, Molecular Psychiatry.

[10]  Xiaotao Xu,et al.  mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress , 2021, Molecular Neurobiology.

[11]  P. Conn,et al.  Targeting metabotropic glutamate receptors for the treatment of depression and other stress-related disorders , 2021, Neuropharmacology.

[12]  N. Bondar,et al.  The Role of Stress-Induced Changes of Homer1 Expression in Stress Susceptibility , 2021, Biochemistry (Moscow).

[13]  P. Svenningsson,et al.  P11 (S100A10) as a potential predictor of ketamine response in patients with SSRI-resistant depression. , 2021, Journal of affective disorders.

[14]  T. Plösch,et al.  Antidepressant treatment is associated with epigenetic alterations of Homer1 promoter in a mouse model of chronic depression. , 2020, Journal of affective disorders.

[15]  M. Picciotto,et al.  Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses , 2020, Molecular Psychiatry.

[16]  E. Ballard,et al.  Network Changes in Insula and Amygdala Connectivity Accompany Implicit Suicidal Associations , 2020, Frontiers in Psychiatry.

[17]  J. Kleinman,et al.  Sex differences in the transcription of glutamate transporters in major depression and suicide. , 2020, Journal of affective disorders.

[18]  Yanjun Cao,et al.  mGluR5 mediates ketamine antidepressant response in susceptible rats exposed to prenatal stress. , 2020, Journal of affective disorders.

[19]  P. Greengard,et al.  AP-1 controls the p11-dependent antidepressant response , 2020, Molecular Psychiatry.

[20]  Fengfei Ding,et al.  Neuroprotective efficacy of different levels of high-frequency repetitive transcranial magnetic stimulation in mice with CUMS-induced depression: Involvement of the p11/BDNF/Homer1a signaling pathway. , 2020, Journal of psychiatric research.

[21]  K. Hashimoto Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine. , 2020, Biochemical pharmacology.

[22]  Feng Wu,et al.  Structural and Functional Abnormities of Amygdala and Prefrontal Cortex in Major Depressive Disorder With Suicide Attempts , 2020, Frontiers in Psychiatry.

[23]  M. van den Buuse,et al.  Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders , 2020, Molecular Psychiatry.

[24]  Cheng-Ta Li,et al.  Antidepressant and antisuicidal effects of ketamine on the functional connectivity of prefrontal cortex-related circuits in treatment-resistant depression: A double-blind, placebo-controlled, randomized, longitudinal resting fMRI study. , 2019, Journal of affective disorders.

[25]  P. Courtet,et al.  Suicide Has Many Faces, So Does Ketamine: a Narrative Review on Ketamine’s Antisuicidal Actions , 2019, Current Psychiatry Reports.

[26]  A. Serretti,et al.  Cortico-limbic functional connectivity mediates the effect of early life stress on suicidality in bipolar depressed 5-HTTLPR*s carriers. , 2019, Journal of affective disorders.

[27]  M. Picciotto,et al.  GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions. , 2019, The Journal of clinical investigation.

[28]  R. Shelton,et al.  Ketamine for acute suicidal ideation. An emergency department intervention: A randomized, double‐blind, placebo‐controlled, proof‐of‐concept trial , 2019, Depression and anxiety.

[29]  C. Loo,et al.  Ketamine for suicidal ideation in adults with psychiatric disorders: A systematic review and meta-analysis of treatment trials , 2019, The Australian and New Zealand journal of psychiatry.

[30]  A. Bertelsen,et al.  Hippocampal volume and cell number in depression, schizophrenia, and suicide subjects , 2019, Brain Research.

[31]  M. Lindsay,et al.  Ketamine Increases Proliferation of Human iPSC-Derived Neuronal Progenitor Cells via Insulin-Like Growth Factor 2 and Independent of the NMDA Receptor , 2019, Cells.

[32]  K. Hawton,et al.  Effects of ketamine treatment on suicidal ideation: a qualitative study of patients’ accounts following treatment for depression in a UK ketamine clinic , 2019, BMJ Open.

[33]  J. Rey,et al.  Intranasal Esketamine (SpravatoTM) for Use in Treatment-Resistant Depression In Conjunction With an Oral Antidepressant. , 2019, P & T : a peer-reviewed journal for formulary management.

[34]  Sophie E. Holmes,et al.  In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation , 2019, Proceedings of the National Academy of Sciences.

[35]  J. Krystal,et al.  Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments , 2019, Neuron.

[36]  S. Cuzzocrea,et al.  Role of Metabotropic Glutamate Receptors in Neurological Disorders , 2019, Front. Mol. Neurosci..

[37]  E. Forbes,et al.  Amygdala Functional Connectivity During Self-Face Processing in Depressed Adolescents With Recent Suicide Attempt. , 2019, Journal of the American Academy of Child and Adolescent Psychiatry.

[38]  M. Waye,et al.  Associations of Homer Scaffolding Protein 1 gene and psychological correlates with suicide attempts in Chinese: A pilot study of multifactorial risk model. , 2018, Gene.

[39]  Fei Wang,et al.  Amygdala functional connectivity in female patients with major depressive disorder with and without suicidal ideation , 2018, Annals of General Psychiatry.

[40]  J. Ramos-Quiroga,et al.  Antidepressant Efficacy and Tolerability of Ketamine and Esketamine: A Critical Review , 2018, CNS Drugs.

[41]  W. Drevets,et al.  Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study. , 2018, The American journal of psychiatry.

[42]  P. Jedlicka,et al.  Synaptic Plasticity and Excitation-Inhibition Balance in the Dentate Gyrus: Insights from In Vivo Recordings in Neuroligin-1, Neuroligin-2, and Collybistin Knockouts , 2018, Neural plasticity.

[43]  R. Shelton,et al.  Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial , 2017, JAMA psychiatry.

[44]  Sophie E. Holmes,et al.  Metabotropic Glutamatergic Receptor 5 and Stress Disorders: Knowledge Gained From Receptor Imaging Studies , 2017, Biological Psychiatry.

[45]  B. Giros,et al.  Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide , 2017, Translational Psychiatry.

[46]  C. Phillips Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection , 2017, Neural plasticity.

[47]  Tianwei Lin,et al.  Antidepressant-like activity of icariin mediated by group I mGluRs in prenatally stressed offspring , 2017, Brain and Development.

[48]  Sophie E. Holmes,et al.  Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence , 2017, Proceedings of the National Academy of Sciences.

[49]  G. Turecki,et al.  Neuropathology of suicide: recent findings and future directions , 2017, Molecular Psychiatry.

[50]  I. Zaletel,et al.  Hippocampal BDNF in physiological conditions and social isolation , 2017, Reviews in the neurosciences.

[51]  M. Waye,et al.  Resequencing three candidate genes discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese. , 2017, Gene.

[52]  R. Parsey,et al.  Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression , 2017, Molecular Psychiatry.

[53]  Eric D A Hermes,et al.  Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. , 2017, The American journal of psychiatry.

[54]  M. Waye,et al.  Association of HOMER1 rs2290639 with suicide attempts in Hong Kong Chinese and the potentially functional role of this polymorphism , 2016, SpringerPlus.

[55]  S. Duan,et al.  A significant association between BDNF promoter methylation and the risk of drug addiction. , 2016, Gene.

[56]  J. Henley,et al.  Synaptic AMPA receptor composition in development, plasticity and disease , 2016, Nature Reviews Neuroscience.

[57]  R. Heumann,et al.  Signaling pathways regulating Homer1a expression: implications for antidepressant therapy , 2016, Biological chemistry.

[58]  B. Dean,et al.  Changes in cortical N-methyl-d-aspartate receptors and post-synaptic density protein 95 in schizophrenia, mood disorders and suicide , 2016, The Australian and New Zealand journal of psychiatry.

[59]  K. Hashimoto,et al.  Serum n-3 polyunsaturated fatty acids and psychological distress in early pregnancy: Adjunct Study of Japan Environment and Children's Study , 2016, Translational Psychiatry.

[60]  P. Greengard,et al.  p11 regulates the surface localization of mGluR5 , 2015, Molecular Psychiatry.

[61]  P. Greengard,et al.  Alteration by p11 of mGluR5 localization regulates depression-like behaviors , 2015, Molecular Psychiatry.

[62]  Jiwon Choi,et al.  mGluR5 in the nucleus accumbens is critical for promoting resilience to chronic stress , 2015, Nature Neuroscience.

[63]  C. Turck,et al.  Homer1/mGluR5 Activity Moderates Vulnerability to Chronic Social Stress , 2015, Neuropsychopharmacology.

[64]  Jamie L. Hanson,et al.  Behavioral Problems After Early Life Stress: Contributions of the Hippocampus and Amygdala , 2015, Biological Psychiatry.

[65]  M. Śmiałowska,et al.  Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression , 2014, Behavioural Brain Research.

[66]  G. Turecki,et al.  Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression. , 2014, The international journal of neuropsychopharmacology.

[67]  Zhi-qiang Zhou,et al.  Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex , 2014, European Psychiatry.

[68]  S. Chaki,et al.  Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats , 2014, Behavioural Brain Research.

[69]  J. Herman,et al.  Glucocorticoid actions on synapses, circuits, and behavior: Implications for the energetics of stress , 2014, Frontiers in Neuroendocrinology.

[70]  S. Stahl,et al.  Novel agents in development for the treatment of depression , 2013, CNS Spectrums.

[71]  J. Wierońska,et al.  Is the mGlu5 receptor a possible target for new antidepressant drugs? , 2013, Pharmacological reports : PR.

[72]  P. Greengard,et al.  p11 and its role in depression and therapeutic responses to antidepressants , 2013, Nature Reviews Neuroscience.

[73]  P. Pregelj,et al.  The role of brain-derived neurotrophic factor in the pathophysiology of suicidal behavior. , 2013, Psychiatria Danubina.

[74]  J. Manzanares,et al.  Gene and protein alterations of FKBP5 and glucocorticoid receptor in the amygdala of suicide victims , 2013, Psychoneuroendocrinology.

[75]  R. Lebel,et al.  Structural Changes in Hippocampal Subfields in Major Depressive Disorder: A High-Field Magnetic Resonance Imaging Study , 2013, Biological Psychiatry.

[76]  M. Boldrini,et al.  Hippocampal Granule Neuron Number and Dentate Gyrus Volume in Antidepressant-Treated and Untreated Major Depression , 2013, Neuropsychopharmacology.

[77]  G. Rajkowska,et al.  Hippocampal volume and total cell numbers in major depressive disorder. , 2013, Journal of psychiatric research.

[78]  S. Chaki,et al.  mGlu2/3 and mGlu5 receptors: Potential targets for novel antidepressants , 2013, Neuropharmacology.

[79]  M. Millan,et al.  Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine , 2013, Psychopharmacology.

[80]  Daniel J. Whitcomb,et al.  Translational Concepts of mGluR5 in Synaptic Diseases of the Brain , 2012, Front. Pharmacol..

[81]  J. Kennedy,et al.  The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis. , 2012, The international journal of neuropsychopharmacology.

[82]  T. Manabe,et al.  Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L‐type Ca2+ channel in mouse CA1 pyramidal cells , 2012, The Journal of physiology.

[83]  J. Kennedy,et al.  Association study of early-immediate genes in childhood-onset mood disorders and suicide attempt , 2012, Psychiatry Research.

[84]  V. Diwadkar,et al.  Structural brain abnormalities and suicidal behavior in borderline personality disorder. , 2012, Journal of psychiatric research.

[85]  K. Pajer,et al.  Impaired decision making in adolescent suicide attempters. , 2012, Journal of the American Academy of Child and Adolescent Psychiatry.

[86]  P. Worley,et al.  Epigenetic Modulation of Homer1a Transcription Regulation in Amygdala and Hippocampus with Pavlovian Fear Conditioning , 2012, The Journal of Neuroscience.

[87]  L. Minuzzi,et al.  Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: An autoradiographic study , 2012, Brain Research Bulletin.

[88]  Zhen Yan,et al.  The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission , 2011, Nature Reviews Neuroscience.

[89]  S. Chaki,et al.  Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression , 2011, Behavioural Brain Research.

[90]  Cheng-Ta Li,et al.  P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide. , 2011, Journal of psychiatric research.

[91]  E. Sibille,et al.  Reduced somatostatin in subgenual anterior cingulate cortex in major depression , 2011, Neurobiology of Disease.

[92]  D. Rujescu,et al.  Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients. , 2011, Journal of psychiatric research.

[93]  C. Heeringen,et al.  Neuroscience and Biobehavioral Reviews Suicidal Brains: a Review of Functional and Structural Brain Studies in Association with Suicidal Behaviour , 2022 .

[94]  Mathias V. Schmidt,et al.  Individual Stress Vulnerability Is Predicted by Short-Term Memory and AMPA Receptor Subunit Ratio in the Hippocampus , 2010, The Journal of Neuroscience.

[95]  N. Tronson,et al.  Metabotropic Glutamate Receptor 5/Homer Interactions Underlie Stress Effects on Fear , 2010, Biological Psychiatry.

[96]  P. Greengard,et al.  A Role for p11 in the Antidepressant Action of Brain-Derived Neurotrophic Factor , 2010, Biological Psychiatry.

[97]  S. Cichon,et al.  Genome-Wide Association-, Replication-, and Neuroimaging Study Implicates HOMER1 in the Etiology of Major Depression , 2010, Biological Psychiatry.

[98]  Norbert Schuff,et al.  Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder. , 2010, Archives of general psychiatry.

[99]  Paul B. Fitzgerald,et al.  Evidence of Cortical Inhibitory Deficits in Major Depressive Disorder , 2010, Biological Psychiatry.

[100]  J. Uslaner,et al.  Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus , 2009, Neuropharmacology.

[101]  G. Muscettola,et al.  HOMER1 Promoter Analysis in Parkinson’s Disease: Association Study with Psychotic Symptoms , 2009, Neuropsychobiology.

[102]  R. Anwyl,et al.  Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene-environment rat model of depression. , 2009, The international journal of neuropsychopharmacology.

[103]  M. Furey,et al.  Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression , 2008, Brain Structure and Function.

[104]  T. Su,et al.  p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter , 2008, Neuroscience.

[105]  H. Anisman,et al.  Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects. , 2008, Journal of psychiatry & neuroscience : JPN.

[106]  R. Huganir,et al.  The cell biology of synaptic plasticity: AMPA receptor trafficking. , 2007, Annual review of cell and developmental biology.

[107]  P. Worley,et al.  Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors , 2007, Proceedings of the National Academy of Sciences.

[108]  P. Courtet,et al.  Impaired decision-making in suicide attempters may increase the risk of problems in affective relationships. , 2007, Journal of affective disorders.

[109]  T. Soderling,et al.  Regulatory mechanisms of AMPA receptors in synaptic plasticity , 2007, Nature Reviews Neuroscience.

[110]  M. Frye,et al.  Low Cerebrospinal Fluid Glutamate and Glycine in Refractory Affective Disorder , 2007, Biological Psychiatry.

[111]  Xia Li,et al.  Metabotropic Glutamate 5 Receptor Antagonism Is Associated with Antidepressant-Like Effects in Mice , 2006, Journal of Pharmacology and Experimental Therapeutics.

[112]  M. Pfaffl,et al.  Comparison of relative mRNA quantification models and the impact of RNA integrity in quantitative real-time RT-PCR , 2006, Biotechnology Letters.

[113]  Michael W Pfaffl,et al.  RNA integrity and the effect on the real-time qRT-PCR performance. , 2006, Molecular aspects of medicine.

[114]  Marc Flajolet,et al.  Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States , 2006, Science.

[115]  P. Worley,et al.  Distinct Roles for Different Homer1 Isoforms in Behaviors and Associated Prefrontal Cortex Function , 2005, The Journal of Neuroscience.

[116]  P. Worley,et al.  Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia , 2005, Genes, brain, and behavior.

[117]  M. Schwald,et al.  Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. , 2005, Brain research. Molecular brain research.

[118]  M. Leboyer,et al.  Impaired decision making in suicide attempters. , 2005, The American journal of psychiatry.

[119]  I. Izquierdo,et al.  One-trial aversive learning induces late changes in hippocampal CaMKIIalpha, Homer 1a, Syntaxin 1a and ERK2 protein levels. , 2004, Brain research. Molecular brain research.

[120]  B. Moghaddam,et al.  Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release , 2004, Neuropsychopharmacology.

[121]  K. Inokuchi,et al.  Activation of ERK cascade promotes accumulation of Vesl-1S/Homer-1a immunoreactivity at synapses. , 2003, Brain research. Molecular brain research.

[122]  Yogesh K. Dwivedi,et al.  Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. , 2003, Archives of general psychiatry.

[123]  N. Norton,et al.  Mutation screening of the Homer gene family and association analysis in schizophrenia , 2003, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[124]  G. Slegers,et al.  Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide. , 2003, Journal of Affective Disorders.

[125]  Carol A Barnes,et al.  Experience-Dependent Coincident Expression of the Effector Immediate-Early Genes Arc and Homer 1a in Hippocampal and Neocortical Neuronal Networks , 2002, The Journal of Neuroscience.

[126]  David Robbe,et al.  Homer-Dependent Cell Surface Expression of Metabotropic Glutamate Receptor Type 5 in Neurons , 2002, Molecular and Cellular Neuroscience.

[127]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[128]  M. Papp,et al.  Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression. , 2001, Polish journal of pharmacology.

[129]  P. Worley,et al.  Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer , 2001, Nature.

[130]  F. Nicoletti,et al.  Molecular determinants of metabotropic glutamate receptor signaling. , 2001, Trends in pharmacological sciences.

[131]  P. Worley,et al.  Dendritic and Axonal Targeting of Type 5 Metabotropic Glutamate Receptor Is Regulated by Homer1 Proteins and Neuronal Excitation , 2000, Journal of Neuroscience.

[132]  J. Pettegrew,et al.  Increased cerebrospinal fluid glutamine levels in depressed patients , 2000, Biological Psychiatry.

[133]  C Waternaux,et al.  Toward a clinical model of suicidal behavior in psychiatric patients. , 1999, The American journal of psychiatry.

[134]  A. Hillmer,et al.  The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders. , 2023, International review of neurobiology.