Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis

[1]  K. Wiesmüller,et al.  NSP4 Is Stored in Azurophil Granules and Released by Activated Neutrophils as Active Endoprotease with Restricted Specificity , 2013, The Journal of Immunology.

[2]  H. Shimomura,et al.  Specificity of antimicrobial peptide LL-37 to neutralize periodontopathogenic lipopolysaccharide activity in human oral fibroblasts. , 2013, Journal of periodontology.

[3]  Liliane Schoofs,et al.  A comprehensive summary of LL-37, the factotum human cathelicidin peptide. , 2012, Cellular immunology.

[4]  U. Kornak,et al.  The Antimicrobial Peptide, LL-37, Inhibits in vitro Osteoclastogenesis , 2012, Journal of dental research.

[5]  G. Hajishengallis,et al.  The keystone-pathogen hypothesis , 2012, Nature Reviews Microbiology.

[6]  B. Paster,et al.  The subgingival microbiota of Papillon-Lefèvre syndrome. , 2012, Journal of periodontology.

[7]  M. Selsted,et al.  High Fidelity Processing and Activation of the Human α-Defensin HNP1 Precursor by Neutrophil Elastase and Proteinase 3 , 2012, PloS one.

[8]  N. Mookherjee,et al.  Cationic Host Defence Peptides: Multifaceted Role in Immune Modulation and Inflammation , 2012, Journal of Innate Immunity.

[9]  Wuyuan Lu,et al.  α‐Defensins in human innate immunity , 2012, Immunological reviews.

[10]  L. Engstrand,et al.  Mutations in the ELANE Gene are Associated with Development of Periodontitis in Patients with Severe Congenital Neutropenia , 2011, Journal of Clinical Immunology.

[11]  J. Potempa,et al.  Comparison of gingival crevicular fluid sampling methods in patients with severe chronic periodontitis. , 2011, Journal of periodontology.

[12]  S. Eick,et al.  Comparison of real-time polymerase chain reaction and DNA-strip technology in microbiological evaluation of periodontitis treatment. , 2011, Diagnostic microbiology and infectious disease.

[13]  B. Dalgıç,et al.  Pyogenic liver abscess and peritonitis due to Rhizopus oryzae in a child with Papillon–Lefevre syndrome , 2011, European Journal of Pediatrics.

[14]  M. Horwitz,et al.  Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases , 2010, Pharmacological Reviews.

[15]  B. Henderson,et al.  Aggregatibacter (Actinobacillus) actinomycetemcomitans: a triple A* periodontopathogen? , 2010, Periodontology 2000.

[16]  P. Papapanou,et al.  Epidemiologic patterns of chronic and aggressive periodontitis. , 2010, Periodontology 2000.

[17]  J. Potempa,et al.  Analysis of neutrophil-derived antimicrobial peptides in gingival crevicular fluid suggests importance of cathelicidin LL-37 in the innate immune response against periodontogenic bacteria. , 2008, Oral microbiology and immunology.

[18]  H. Schackert,et al.  Functional Cathepsin C mutations cause different Papillon-Lefèvre syndrome phenotypes. , 2008, Journal of clinical periodontology.

[19]  T. Hart,et al.  Mendelian forms of periodontitis. , 2007, Periodontology 2000.

[20]  B. Lee,et al.  Susceptibility of various oral bacteria to antimicrobial peptides and to phagocytosis by neutrophils. , 2007, Journal of periodontal research.

[21]  H. Shimauchi,et al.  Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients. , 2007, Molecular immunology.

[22]  S. Normark,et al.  Neutrophil extracellular traps: casting the NET over pathogenesis. , 2007, Current opinion in microbiology.

[23]  F. Baron,et al.  Periodontal therapy in siblings with Papillon-Lefèvre syndrome and tinea capitis: a report of two cases. , 2006, Journal of clinical periodontology.

[24]  V. Everts,et al.  Role of Polymorphonuclear Leukocyte-Derived Serine Proteinases in Defense against Actinobacillus actinomycetemcomitans , 2006, Infection and Immunity.

[25]  T. Hart,et al.  Clinical, genetic, and biochemical findings in two siblings with Papillon-Lefèvre Syndrome. , 2005, Journal of periodontology.

[26]  A. Read,et al.  Coinheritance of two rare genodermatoses (Papillon–Lefèvre syndrome and oculocutaneous albinism type 1) in two families: a genetic study , 2004, The British journal of dermatology.

[27]  H. Schackert,et al.  Novel Mutations in the Cathepsin C Gene in Patients with Pre-pubertal Aggressive Periodontitis and Papillon-Lefèvre Syndrome , 2004, Journal of dental research.

[28]  Andrew P Read,et al.  The role of cathepsin C in Papillon‐Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis , 2004, Human mutation.

[29]  J. Reynolds,et al.  Cytokines, matrix metalloproteinases and tissue inhibitor of metalloproteinases‐1 in gingival crevicular fluid from patients with Papillon‐Lefèvre syndrome , 2004, Acta odontologica Scandinavica.

[30]  K. Muramoto,et al.  Neutrophil Serine Proteinases Activate Human Nonepithelial Cells to Produce Inflammatory Cytokines Through Protease-Activated Receptor 21 , 2003, The Journal of Immunology.

[31]  V. Nizet,et al.  Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. , 2003, The Journal of investigative dermatology.

[32]  上原 亜希子 Activation of human oral epithelial cells by neutrophil proteinase 3 through protease-activated receptor-2 , 2003 .

[33]  Göran Carlsson,et al.  Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study , 2002, The Lancet.

[34]  A. Belaaouaj Neutrophil elastase-mediated killing of bacteria: lessons from targeted mutagenesis. , 2002, Microbes and infection.

[35]  Giorgio Gabella,et al.  Killing activity of neutrophils is mediated through activation of proteases by K+ flux , 2002, Nature.

[36]  J. Calafat,et al.  Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. , 2001, Blood.

[37]  P. Eickholz,et al.  Combined mechanical and antibiotic periodontal therapy in a case of Papillon-Lefèvre syndrome. , 2001, Journal of periodontology.

[38]  R. Lehrer,et al.  Sensitivity of Actinobacillus actinomycetemcomitans and Capnocytophaga spp. to the bactericidal action of LL-37: a cathelicidin found in human leukocytes and epithelium. , 2000, Oral microbiology and immunology.

[39]  P. A. Raj,et al.  Large-scale synthesis and functional elements for the antimicrobial activity of defensins. , 2000, The Biochemical journal.

[40]  G. Armitage,et al.  Development of a classification system for periodontal diseases and conditions. , 1999, Annals of periodontology.

[41]  C. Cao,et al.  Leukocyte functions in 2 cases of Papillon-Lefèvre syndrome. , 2000, Journal of clinical periodontology.

[42]  T. Flemmig,et al.  Combined systemic and local antimicrobial therapy of periodontal disease in Papillon-Lefèvre syndrome. A report of 4 cases. , 1999, Journal of clinical periodontology.

[43]  Emma Roberts,et al.  Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis , 1999, Nature Genetics.

[44]  G. Seymour,et al.  Microbiological and serological investigations of oral lesions in Papillon-Lefèvre syndrome. , 1996, Journal of clinical pathology.

[45]  J. Hoidal,et al.  Biosynthesis and Processing of Proteinase 3 in U937 Cells , 1996, The Journal of Biological Chemistry.

[46]  W. Shafer,et al.  Human lysosomal cathepsin G and granzyme B share a functionally conserved broad spectrum antibacterial peptide. , 1991, The Journal of biological chemistry.

[47]  T. Ganz,et al.  In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins , 1990, Infection and immunity.

[48]  H. Schägger,et al.  Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. , 1987, Analytical biochemistry.

[49]  S. Socransky,et al.  The Papillon-Lefèvre syndrome: neutrophil dysfunction with severe periodontal disease. , 1984, Clinical immunology and immunopathology.