Intoxication by tremorgenic mycotoxin (penitrem A) in a dog.

A 1-year-old Siberian Husky dog presented with severe muscle tremors after ingestion of a mouldy hamburger bun. Penicillium crustosum and the tremorgenic mycotoxin penitrem A were isolated from the remaining portion of the hamburger bun. When grown in pure culture, the isolate of P. crustosum produced large amounts of penitrem A, along with other penitrem compounds. This is the first reported Australian case of toxicosis by naturally occurring penitrem A.

[1]  D. Lauren,et al.  Effect of culture conditions on tremorgen production by some Penicillium species , 1986, Applied and environmental microbiology.

[2]  C. Reid,et al.  The role of fungal tremorgens in ryegrass staggers , 1977 .

[3]  C. W. Hesseltine,et al.  Tremorgenic toxins from Penicillia. I. Colorimetric determination of tremortins A and B. , 1970, Analytical biochemistry.

[4]  M. Tizard,et al.  A novel process for the production of penitrem mycotoxins by submerged fermentation of Penicillium nigricans. , 1984, Journal of general microbiology.

[5]  P. Mantle,et al.  Mycotoxic tremorgens of Claviceps paspali and Penicillium cyclopium: a comparative study of effects on sheep and cattle in relation to natural staggers syndromes. , 1978, Research in veterinary science.

[6]  W. Hull,et al.  Structure and biosynthesis of the penitrems A–F, six novel tremorgenic mycotoxins from Penicillium crustosum , 1981 .

[7]  G. Smith,et al.  Absorption and translocation of Penicillium by ryegrass plants. , 1980 .

[8]  A. Hayes,et al.  Acute toxicity of penitrem A in dogs. , 1976, Toxicology and applied pharmacology.

[9]  W. Dettbarn,et al.  Effects of a fungus tremorgenic toxin (penitrem A) on transmission in rat phrenic nerve-diaphragm preparations. , 1972, Brain research.

[10]  P. Steyn,et al.  High-performance liquid chromatography and thin-layer chromatography of penitrems A–F, tremorgenic mycotoxins from Penicillium crustosum , 1982 .

[11]  J. Pitt Penicillium crustosum and P. simplicissimum, the Correct Names for Two Common Species Producing Tremorgenic Mycotoxins , 1979 .

[12]  Arp Lh,et al.  Intoxication of dogs with the mycotoxin penitrem A. , 1979 .

[13]  R. Penny,et al.  A comparative study of sheep and pigs given the tremorgenic mycotoxins verruculogen and penitrem A. , 1982, Research in veterinary science.