Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunode fi ciency virus * Clinical Microbiology and Infection

Objective: To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fi brosis/cirrhosis in HCV seroconverters among persons with human immunode fi ciency virus (HIV) infection. Methods: We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy. Results: Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men- who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fi brosis/ cirrhosis was 30% by 10 years after seroconversion. Conclusions: New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals. M. Puoti, Clin Microbiol Infect

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