Influence of Fructus Aurantii Immaturus Flavonoids on Gastrointestinal Motility in Rats with Functional Dyspepsia

Objective To investigate the effect of flavonoids in Fructus Aurantii Immaturus on gastrointestinal motility in rats with functional dyspepsia and to explore its possible mechanism.Methods A total of 60 adult wistar rats were randomly divided into six groups,normal control group,model control group,domperidone group,hesperidin group,neohesperidin group,and naringin group.After treatment,serum motilin(MTL) and vasoactive intestinal peptide(VIP) levels were measured by ELISA,gastric emptying rate and small intestinal propulsion rate were examined.Results Compared with the normal control group,the gastric emptying rate and small intestinal propulsion rate in the model group were markedly decreased(P 0.05,P 0.01).After treatment,the gastric emptying rate and small intestinal propulsion rate were increased in hesperidin group,neohesperidin group and naringin group,which were similar to those in normal control group and domperidone group(P 0.05).MTL level was decreased significantly(P 0.05) and VIP level was significantly increased(P 0.05) in the model group.After treatment with hesperidin,MTL was recovered to the level in normal control group and domperidone group(P 0.05).Conclusion The flavonoids in Fructus Aurantii Immaturus can promote gastrointestinal motility in rats with functional dyspepsia,and hesperidin can improve MTL level.