Wound Healing Activity of Ethanolic Extract Of Hemidesmus Indicus (Linn) R.Br Leaves In Rats

The study was carried out to evaluate the wound healing activity of ethanolic extract of Hemidesmus indicus leaves in rats. Twenty four healthy animals of Wister strain were assigned to four groups, containing six animals each. Group 1 (positive control) was provided with nitrofurantoin ointment, group 2 (solvent control) with 70% ethanol, group 3 (test dose I) with 5% w/w Hemidesmus indicus ointment and group 4 (test dose II) with 10% w/w Hemidesmus indicus ointment. The total exposure of the study was 16 days. The groups were compared for the percentage of wound healing. It was observed that the group treated with nitrofurantoin ointment showed an increase in the rate and percentage of wound contraction and period of epithelization compared to the ethanol treated group. The alcoholic extract of Hemidesmus indicus (5% and 10% ointment) increased rate of wound contraction and period of epithelization than solvent and control groups. Comparison between test dose I and test dose II showed that the percentage and rate of wound healing was increased at test dose I than test dose II. The