Monte Carlo modeling of light propagation in highly scattering tissues. II. Comparison with measurements in phantoms

For pt.I see ibid., vol.36, no.12, p.1162-8 (1989). Measurements of the fluence-depth distributions and the diffuse reflectance of 633-nm light in liquid media with optical properties similar to soft tissues are discussed. The results are compared with predictions of Monte Carlo computer calculations in order to test the adequacy of Monte Carlo modeling of light transport in tissues. Except at extremely high albedo, the experimental data and the Monte Carlo results agree well for the depth dependence of the fluence as a function of incident light beam diameter and optical absorption and scattering, and for the dependence of the diffuse reflectance on the albedo. The absolute experimental values for the fluence must be renormalized by a factor which varies with the albedo in order to match the model values, and the possible sources of this discrepancy are discussed.<<ETX>>

[1]  A Ishimaru,et al.  Diffuse reflectance from a finite blood medium: applications to the modeling of fiber optic catheters. , 1976, Applied optics.

[2]  R. Hemenger,et al.  Optical properties of turbid media with specularly reflecting boundaries: applications to biological problems. , 1977, Applied optics.

[3]  Van de Hulst,et al.  Multiple Light Scattering: Tables, Formulas, and Applications , 1980 .

[4]  B. Wilson,et al.  Similarity relations for anisotropic scattering in monte carlo simulations of deeply penetrating neu , 1989 .

[5]  A E Profio,et al.  Fluorescence of HpD for tumor detection and dosimetry in photoradiation therapy. , 1984, Progress in clinical and biological research.

[6]  M. V. van Gemert,et al.  Light dosimetry: status and prospects. , 1987, Journal of photochemistry and photobiology. B, Biology.

[7]  M S Patterson,et al.  Total attenuation coefficients and scattering phase functions of tissues and phantom materials at 633 nm. , 1987, Medical physics.

[8]  M S Patterson,et al.  INDIRECT VERSUS DIRECT TECHNIQUES FOR THE MEASUREMENT OF THE OPTICAL PROPERTIES OF TISSUES , 1987, Photochemistry and photobiology.

[9]  M. Keijzer,et al.  LIGHT DOSIMETRY FOR PHOTODYNAMIC THERAPY BY WHOLE BLADDER WALL IRRADIATION , 1987, Photochemistry and photobiology.

[10]  B. Wilson,et al.  Monte Carlo modeling of light propagation in highly scattering tissues. I. Model predictions and comparison with diffusion theory , 1989, IEEE Transactions on Biomedical Engineering.