论文信息 - UGT bioactivation of AαC 1 UDP-Glucuronosyltransferase-Mediated Metabolic Activation of the Tobacco Carcinogen 2-Amino-9 H-Pyrido [ 2 , 3-b ] indole *

UGT bioactivation of AαC 1 UDP-Glucuronosyltransferase-Mediated Metabolic Activation of the Tobacco Carcinogen 2-Amino-9 H-Pyrido [ 2 , 3-b ] indole *

Background: 2-Amino-9H-pyrido[2,3-b]indole (AαC) is a carcinogen formed in tobacco smoke, but little is known about its metabolism in humans. Result: UDP-Glucuronosyltransferases catalyze the binding of N-oxidized-AαC to DNA. Conclusion: Glucuronidation, normally a detoxication pathway, contributes to the genotoxicity of AαC. Significance: The exposure to and UGTbioactivation of AαC provides a biochemical mechanism for the elevated risk of liver and digestive tract cancers in smokers.

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