Iron Overload Causes Oxidative Stress and Impaired Insulin Signaling in AML-12 Hepatocytes

[1]  James E. Nelson,et al.  Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations , 2012, Hepatology.

[2]  L. N. Valenti,et al.  Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target. , 2011, Journal of hepatology.

[3]  James E. Nelson,et al.  Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease , 2011, Hepatology.

[4]  H. Yki-Järvinen.  Nutritional modulation of nonalcoholic fatty liver disease and insulin resistance: human data , 2010, Current opinion in clinical nutrition and metabolic care.

[5]  B. Neuschwander‐Tetri.  Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites , 2010, Hepatology.

[6]  K. Petersen,et al.  Lipid-induced insulin resistance: unravelling the mechanism , 2010, The Lancet.

[7]  P. Brissot,et al.  Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form , 2010, Journal of Molecular Medicine.

[8]  Matteo Ricchi,et al.  Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes , 2009, Journal of gastroenterology and hepatology.

[9]  T. Okanoue,et al.  Role of hepatic iron in non‐alcoholic steatohepatitis , 2009, Hepatology research : the official journal of the Japan Society of Hepatology.

[10]  P. Micheli,et al.  Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis. , 2009, Journal of hepatology.

[11]  K. Kowdley,et al.  Curcumin reduces the toxic effects of iron loading in rat liver epithelial cells , 2009, Liver international : official journal of the International Association for the Study of the Liver.

[12]  J. Olefsky,et al.  Insulin sensitivity: modulation by nutrients and inflammation. , 2008, The Journal of clinical investigation.

[13]  N. Sattar,et al.  Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations. , 2008, Clinical science.

[14]  R. Leibel,et al.  Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. , 2008, Endocrinology.

[15]  L. Valenti,et al.  Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. , 2008, The American journal of pathology.

[16]  G. Tell,et al.  Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis. , 2008, Trends in molecular medicine.

[17]  K. Pantopoulos,et al.  Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects , 2008 .

[18]  P. Wardman,et al.  Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects. , 2007, Free radical biology & medicine.

[19]  James E. Nelson,et al.  HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis , 2007, Hepatology.

[20]  K. Petersen,et al.  Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction , 2006, Diabetes.

[21]  R. Rodrigo,et al.  Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease. , 2006, Trends in molecular medicine.

[22]  C. Bica,et al.  Prevalence of the hemochromatosis gene mutation in patients with nonalcoholic steatohepatitis and correlation with degree of liver fibrosis. , 2006, Arquivos de gastroenterologia.

[23]  G. Gores,et al.  Free Fatty Acids Induce JNK-dependent Hepatocyte Lipoapoptosis* , 2006, Journal of Biological Chemistry.

[24]  E. Lander,et al.  Reactive oxygen species have a causal role in multiple forms of insulin resistance , 2006, Nature.

[25]  R. Bruck,et al.  Therapeutic potential of curcumin in non-alcoholic steatohepatitis , 2005, Nutrition Research Reviews.

[26]  Joseph L Evans,et al.  The molecular basis for oxidative stress-induced insulin resistance. , 2005, Antioxidants & redox signaling.

[27]  Xianglin Shi,et al.  Metal-induced oxidative stress and signal transduction. , 2004, Free radical biology & medicine.

[28]  C. Sempoux,et al.  Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. , 2004, Journal of hepatology.

[29]  J. Horton,et al.  Molecular mediators of hepatic steatosis and liver injury. , 2004, The Journal of clinical investigation.

[30]  G. Marchesini,et al.  Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver , 2004, Hepatology.

[31]  L. Ridnour,et al.  Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats , 2003, Liver international : official journal of the International Association for the Study of the Liver.

[32]  A. Laudanna,et al.  Lack of evidence for the pathogenic role of iron and HFE gene mutations in Brazilian patients with nonalcoholic steatohepatitis. , 2003, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[33]  J. Eaton,et al.  Molecular bases of cellular iron toxicity. , 2002, Free radical biology & medicine.

[34]  D. J. Messner,et al.  Abbreviated cell cycle progression induced by the serine/threonine protein phosphatase inhibitor okadaic acid at concentrations that promote neoplastic transformation. , 2001, Carcinogenesis.

[35]  J. Kehrer.  The Haber-Weiss reaction and mechanisms of toxicity. , 2000, Toxicology.

[36]  K. Batts,et al.  Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis , 1999, Hepatology.

[37]  H. Bonkovsky,et al.  Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis. , 1999, Journal of hepatology.

[38]  F. Facchini.  Effect of Phlebotomy on Plasma Glucose and Insulin Concentrations , 1998, Diabetes Care.

[39]  D. Gorson.  Reduction of Macroalbuminuria With Pentoxifylline in Diabetic Nephropathy: Report of three cases , 1998, Diabetes Care.

[40]  P. Ward,et al.  Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. , 1998, Gastroenterology.

[41]  B. Neuschwander‐Tetri,et al.  Nonalcoholic steatohepatitis: an expanded clinical entity. , 1994, Gastroenterology.

[42]  G. Merlino,et al.  Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[43]  J. L. Ramírez-Zacarías,et al.  Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with oil red O , 1992, Histochemistry.

[44]  P. Sadler,et al.  Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy. , 1989, The Journal of biological chemistry.

[45]  B. Pressman,et al.  BIOLOGICAL APPLICATIONS OF IONOPHORES: THEORY AND PRACTICE fn1 , 1975 .

[46]  M. Wheby,et al.  EFFECT OF TRANSFERRIN SATURATION ON IRON ABSORPTION IN MAN. , 1964, The New England journal of medicine.

[47]  A. Sanyal.  Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease , 2005, Nature Clinical Practice Gastroenterology &Hepatology.

[48]  C. Wrede,et al.  Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1. , 2001, Endocrinology.