Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia

Dodiya et al. characterize an APPPS1-21 mouse model of Aβ amyloidosis with an antibiotic-perturbed microbiome. Fecal transplantation approaches and microglial depletion studies are employed to establish the causality between the gut microbiota, microglia, Aβ, and neurodegeneration.

[1]  Houeto Jean-Luc.  [Parkinson's disease]. , 2022, La Revue du praticien.

[2]  Haokui Zhou,et al.  Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer's Disease , 2020, BioMed research international.

[3]  M. Prinz,et al.  How microbiota shape microglial phenotypes and epigenetics , 2020, Glia.

[4]  K. Shannon,et al.  Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease , 2020, Neurobiology of Disease.

[5]  J. Elstrott,et al.  Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model , 2020, The Journal of Neuroscience.

[6]  Yanshu Li,et al.  Sex-specific association between the gut microbiome and high-fat diet-induced metabolic disorders in mice , 2020, Biology of sex differences.

[7]  H. Weiner,et al.  The sex-specific interaction of the microbiome in neurodegenerative diseases , 2019, Brain Research.

[8]  Caleb Webber,et al.  CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice , 2019, Brain : a journal of neurology.

[9]  Chao Zhang,et al.  Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model , 2019, Nature Communications.

[10]  Tianyu Gong,et al.  Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice , 2019, Translational Psychiatry.

[11]  K. Blennow,et al.  Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis. , 2019, JAMA neurology.

[12]  J. Gilbert,et al.  Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes , 2019, The Journal of experimental medicine.

[13]  S. Chinnathambi,et al.  Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease , 2019, Cellular and Molecular Life Sciences.

[14]  Alireza Hadj Khodabakhshi,et al.  Metascape provides a biologist-oriented resource for the analysis of systems-level datasets , 2019, Nature Communications.

[15]  F. Naef,et al.  The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism , 2019, Cell metabolism.

[16]  M. Tremblay,et al.  Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury , 2019, Nature Communications.

[17]  M. Bajénoff,et al.  Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal , 2018, The Journal of experimental medicine.

[18]  M. Staufenbiel,et al.  Innate immune memory in the brain shapes neurological disease hallmarks , 2018, Nature.

[19]  F. LaFerla,et al.  Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease , 2018, Molecular Neurodegeneration.

[20]  J. Hanson,et al.  Microglia in Alzheimer’s disease , 2018, The Journal of cell biology.

[21]  I. Amit,et al.  Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner , 2017, Cell.

[22]  M. Heneka,et al.  Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease , 2017, Nature.

[23]  Sterling C. Johnson,et al.  Gut microbiome alterations in Alzheimer’s disease , 2017, Scientific Reports.

[24]  K. Berer,et al.  Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice , 2017, Proceedings of the National Academy of Sciences.

[25]  Stephen L. Hauser,et al.  Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models , 2017, Proceedings of the National Academy of Sciences.

[26]  R. Tanzi,et al.  Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease , 2017, Scientific Reports.

[27]  M. Rosenblum,et al.  A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease , 2017, Nature.

[28]  R. Feil,et al.  Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging , 2017, Nature Neuroscience.

[29]  Maxim N. Artyomov,et al.  TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease , 2017, Cell.

[30]  I. Amit,et al.  A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease , 2017, Cell.

[31]  J. Nicholson,et al.  Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes , 2017, Scientific Reports.

[32]  Tuan Leng Tay,et al.  Microglia across the lifespan: from origin to function in brain development, plasticity and cognition , 2017, The Journal of physiology.

[33]  Jose A Navas-Molina,et al.  Deblur Rapidly Resolves Single-Nucleotide Community Sequence Patterns , 2017, mSystems.

[34]  G. Frisoni,et al.  Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota , 2017, Scientific Reports.

[35]  P. Tognini,et al.  Gut Microbiota: A Potential Regulator of Neurodevelopment , 2017, Front. Cell. Neurosci..

[36]  Rob Knight,et al.  Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease , 2016, Cell.

[37]  Paul J. Lucassen,et al.  The Indispensable Roles of Microglia and Astrocytes during Brain Development , 2016, Front. Hum. Neurosci..

[38]  C. Huttenhower,et al.  Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity , 2016, Cell.

[39]  Daniel H. Geschwind,et al.  The Central Nervous System and the Gut Microbiome , 2016, Cell.

[40]  Ben Nichols,et al.  VSEARCH: a versatile open source tool for metagenomics , 2016, PeerJ.

[41]  Sung Hoon Baik,et al.  Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model , 2016, Glia.

[42]  D. Holtzman,et al.  Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease , 2016, Scientific Reports.

[43]  M. Dichgans,et al.  Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke , 2016, The Journal of Neuroscience.

[44]  M. Staufenbiel,et al.  Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases , 2016, Neuron.

[45]  T. Drake,et al.  Sex differences and hormonal effects on gut microbiota composition in mice , 2016, Gut microbes.

[46]  Laura M Cox,et al.  Alterations of the human gut microbiome in multiple sclerosis , 2016, Nature Communications.

[47]  Måns Magnusson,et al.  MultiQC: summarize analysis results for multiple tools and samples in a single report , 2016, Bioinform..

[48]  B. Stevens,et al.  New insights on the role of microglia in synaptic pruning in health and disease , 2016, Current Opinion in Neurobiology.

[49]  Mariana Vargas-Caballero,et al.  Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology , 2016, Brain : a journal of neurology.

[50]  Jennifer Luebke,et al.  Depletion of microglia and inhibition of exosome synthesis halt tau propagation , 2015, Nature Neuroscience.

[51]  B. Stevens,et al.  Microglia Function in Central Nervous System Development and Plasticity. , 2015, Cold Spring Harbor perspectives in biology.

[52]  Ali Keshavarzian,et al.  Colonic bacterial composition in Parkinson's disease , 2015, Movement disorders : official journal of the Movement Disorder Society.

[53]  L. Lue,et al.  Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains , 2015, Alzheimer's Research & Therapy.

[54]  A. Najafi,et al.  Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice , 2015, Journal of Neuroinflammation.

[55]  P. De Camilli,et al.  Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques , 2015, Proceedings of the National Academy of Sciences.

[56]  I. Amit,et al.  Host microbiota constantly control maturation and function of microglia in the CNS , 2015, Nature Neuroscience.

[57]  Rob Knight,et al.  Analysis of composition of microbiomes: a novel method for studying microbial composition , 2015, Microbial ecology in health and disease.

[58]  Lai Guan Ng,et al.  The gut microbiota influences blood-brain barrier permeability in mice , 2014, Science Translational Medicine.

[59]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[60]  T. Dinan,et al.  Microbiota and neurodevelopmental windows: implications for brain disorders. , 2014, Trends in molecular medicine.

[61]  Paul Theodor Pyl,et al.  HTSeq—a Python framework to work with high-throughput sequencing data , 2014, bioRxiv.

[62]  M. Blaser,et al.  Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences , 2014, Cell.

[63]  J. Hardy,et al.  Genetics of Alzheimer's disease. , 1998, Essays in biochemistry.

[64]  R. Knight,et al.  Finding the missing links among metabolites, microbes, and the host. , 2014, Immunity.

[65]  S. Hornemann,et al.  ASC has extracellular and prionoid activities that propagate inflammation , 2014, Nature Immunology.

[66]  Brian L. West,et al.  Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain , 2014, Neuron.

[67]  A. M. Martín-Moreno,et al.  Leptin gene therapy attenuates neuronal damages evoked by amyloid-β and rescues memory deficits in APP/PS1 mice , 2014, Gene Therapy.

[68]  S. Gygi,et al.  Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia , 2013, Nature Neuroscience.

[69]  Toshiro K. Ohsumi,et al.  The Microglial Sensome Revealed by Direct RNA Sequencing , 2013, Nature Neuroscience.

[70]  Aly A. Khan,et al.  Gender bias in autoimmunity is influenced by microbiota. , 2013, Immunity.

[71]  Mark T. W. Ebbert,et al.  Genetics of Alzheimer's Disease , 2013, BioMed research international.

[72]  Sarah L. Westcott,et al.  Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform , 2013, Applied and Environmental Microbiology.

[73]  Y. Belkaid,et al.  Compartmentalized and systemic control of tissue immunity by commensals , 2013, Nature Immunology.

[74]  Sang-Uk Seo,et al.  Role of the gut microbiota in immunity and inflammatory disease , 2013, Nature Reviews Immunology.

[75]  M. Shoichet,et al.  Positron emission tomography imaging of fibrillar parenchymal and vascular amyloid-β in TgCRND8 mice. , 2013, ACS chemical neuroscience.

[76]  A. K. Hansen,et al.  Customizing laboratory mice by modifying gut microbiota and host immunity in an early “window of opportunity” , 2013, Gut microbes.

[77]  O. Ghribi,et al.  Leptin signaling and Alzheimer's disease. , 2012, American journal of neurodegenerative disease.

[78]  R. Tanzi.  The genetics of Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.

[79]  Amin R. Mazloom,et al.  Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages , 2012, Nature Immunology.

[80]  Hans-Ulrich Demuth,et al.  Prion-Like Behavior and Tau-dependent Cytotoxicity of Pyroglutamylated β-Amyloid , 2012, Nature.

[81]  A. K. Hansen,et al.  Patterns of Early Gut Colonization Shape Future Immune Responses of the Host , 2012, PloS one.

[82]  William A. Walters,et al.  Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms , 2012, The ISME Journal.

[83]  K. Berer,et al.  Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination , 2011, Nature.

[84]  J. Pollard,et al.  Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits , 2011, PloS one.

[85]  E. Kavanagh,et al.  Caspase signalling controls microglia activation and neurotoxicity , 2011, Nature.

[86]  H. Forssberg,et al.  Normal gut microbiota modulates brain development and behavior , 2011, Proceedings of the National Academy of Sciences.

[87]  R. Ransohoff,et al.  CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. , 2010, The American journal of pathology.

[88]  William A. Walters,et al.  Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample , 2010, Proceedings of the National Academy of Sciences.

[89]  William A. Walters,et al.  QIIME allows analysis of high-throughput community sequencing data , 2010, Nature Methods.

[90]  Dan R. Littman,et al.  Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria , 2009, Cell.

[91]  P. Reddy,et al.  Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease. , 2009, Human molecular genetics.

[92]  W. R. Wikoff,et al.  Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites , 2009, Proceedings of the National Academy of Sciences.

[93]  Israel Steinfeld,et al.  BMC Bioinformatics BioMed Central , 2008 .

[94]  Min-Jeong Shin,et al.  Bioplex analysis of plasma cytokines in Alzheimer's disease and mild cognitive impairment. , 2008, Immunology letters.

[95]  Elizabeth Head,et al.  Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers , 2007, Molecular Neurodegeneration.

[96]  S. Mathur,et al.  A novel role of glia maturation factor: induction of granulocyte‐macrophage colony‐stimulating factor and pro‐inflammatory cytokines , 2007, Journal of neurochemistry.

[97]  Colm Cunningham,et al.  Systemic infections and inflammation affect chronic neurodegeneration , 2007, Nature Reviews Immunology.

[98]  Hartwig Wolburg,et al.  Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology , 2006, EMBO reports.

[99]  R. Knight,et al.  UniFrac: a New Phylogenetic Method for Comparing Microbial Communities , 2005, Applied and Environmental Microbiology.

[100]  S. Mazmanian,et al.  An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System , 2005, Cell.

[101]  A. Nagai,et al.  Cytokines, chemokines, and cytokine receptors in human microglia , 2002, Journal of neuroscience research.

[102]  M. Graves,et al.  Cyclooxygenase‐2‐positive macrophages infiltrate the Alzheimer’s disease brain and damage the blood–brain barrier , 2002, European journal of clinical investigation.

[103]  D. Borchelt,et al.  Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. , 2001, Biomolecular engineering.

[104]  L. Adorini,et al.  Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. , 2000, Immunology today.

[105]  D. Teplow,et al.  Metabolism of the Swedish Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells , 1996, The Journal of Biological Chemistry.

[106]  T. Deerinck,et al.  Re‐Evaluation of the Structural Organization of Neuritic Plaques in Alzheimer's Disease , 1993 .

[107]  Brian J Cummings,et al.  Induction of basic fibroblast growth factor in Alzheimer's disease pathology. , 1990, Neuroreport.

[108]  R. Catalano,et al.  Fibroblast growth factor induces beta-amyloid precursor mRNA in glial but not neuronal cultured cells. , 1990, Biochemical and biophysical research communications.

[109]  K. Shannon,et al.  The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy. , 2017, Journal of Parkinson's disease.

[110]  R. Ransohoff,et al.  Microglia in Health and Disease. , 2015, Cold Spring Harbor perspectives in biology.

[111]  Thomas R. Gingeras,et al.  STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..

[112]  Y. Benno,et al.  Gut Bacteria , 2009, Mucosal Immunology.

[113]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[114]  D Giulian,et al.  The impact of microglia-derived cytokines upon gliosis in the CNS. , 1994, Developmental neuroscience.

[115]  M. Fink.  from in the Gut , 2022 .