Relations between intestinal alkaline phosphatase activity and insulin secretion in obese patients.

Adult intestinal alkaline phosphatase (IAP) isoenzyme has long been known to be a minor component of serum alkaline phosphatase (ALP). On electrophoresis it migrates in the β-globulin position and is detectable at low activity (<20% of total ALP) in ∼20% of sera from healthy individuals (1). Increased IAP activity has been reported in chronic renal failure (55%), liver cirrhosis (46%), and diabetes (54%) (2). Moreover, subjects with blood groups O and B have also been reported to have increased serum IAP activity, especially in postprandial samples after a fatty meal (3). A high percentage of IAP-positive samples …