Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis

[1]  M. Lagerquist,et al.  Amelioration of collagen-induced arthritis and immune-associated bone loss through signaling via estrogen receptor alpha, and not estrogen receptor beta or G protein-coupled receptor 30. , 2010, Arthritis and rheumatism.

[2]  J. Gustafsson,et al.  In vivo activation of gene transcription via oestrogen response elements by a raloxifene analogue. , 2009, The Journal of endocrinology.

[3]  F. Cicuttini,et al.  Targeting IL-6 in the treatment of inflammatory and autoimmune diseases , 2009, Expert opinion on investigational drugs.

[4]  J. Zwerina,et al.  Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo. , 2009, Arthritis and rheumatism.

[5]  M. Lagerquist,et al.  Long‐term anti‐arthritic and anti‐osteoporotic effects of raloxifene in established experimental postmenopausal polyarthritis , 2008, Clinical and experimental immunology.

[6]  C. Christiansen,et al.  Oestrogen exhibits type II collagen protective effects and attenuates collagen‐induced arthritis in rats , 2008, Clinical and experimental immunology.

[7]  M. Lagerquist,et al.  Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis. , 2007, Arthritis and rheumatism.

[8]  R. Holmdahl,et al.  Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species. , 2007, The Journal of clinical investigation.

[9]  L. Alfredsson,et al.  A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity , 2007, Arthritis research & therapy.

[10]  V. Beral Ovarian cancer and hormone replacement therapy in the Million Women Study , 2007, The Lancet.

[11]  T. Kvien,et al.  Epidemiological Aspects of Rheumatoid Arthritis , 2006, Annals of the New York Academy of Sciences.

[12]  A. Silman,et al.  Risk factors for the development of rheumatoid arthritis , 2006, Scandinavian journal of rheumatology.

[13]  F. Orio,et al.  Antiproliferative and proapoptotic effects of raloxifene on uterine leiomyomas in postmenopausal women. , 2005, Fertility and sterility.

[14]  C. Ohlsson,et al.  Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation , 2005, Arthritis research & therapy.

[15]  R. Holmdahl,et al.  Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[16]  L. Levine Tamoxifen and the Rafoxifene analog LY117018: their effects on arachidonic acid release from cells in culture and on prostaglandin I2 production by rat liver cells , 2004, BMC Cancer.

[17]  John Robbins,et al.  National cross sectional survey to determine whether the decision to delivery interval is critical in emergency caesarean section , 2004, BMJ : British Medical Journal.

[18]  Mark Garton,et al.  Breast cancer and hormone-replacement therapy: the Million Women Study , 2003, The Lancet.

[19]  D. Mellström,et al.  Radiographic joint destruction in postmenopausal rheumatoid arthritis is strongly associated with generalised osteoporosis , 2003, Annals of the rheumatic diseases.

[20]  D. Mellström,et al.  Influence of hormone replacement therapy on disease progression and bone mineral density in rheumatoid arthritis. , 2003, The Journal of rheumatology.

[21]  C. Ohlsson,et al.  Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice. , 2002, The Journal of endocrinology.

[22]  Charles Kooperberg,et al.  Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. , 2002, JAMA.

[23]  S. Gabriel,et al.  Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. , 2002, Arthritis and rheumatism.

[24]  R. Holmdahl,et al.  Enhancement of collagen-induced arthritis in female mice by estrogen receptor blockage. , 2001, Arthritis and rheumatism.

[25]  H. Carlsten,et al.  Effects of raloxifene, a selective estrogen receptor modulator, on thymus, T cell reactivity, and inflammation in mice. , 2000, Cellular immunology.

[26]  S. Adami,et al.  A multicenter cross sectional study on bone mineral density in rheumatoid arthritis. Italian Study Group on Bone Mass in Rheumatoid Arthritis. , 2000, The Journal of rheumatology.

[27]  N. Dubin,et al.  The effect of raloxifene on the uterine weight response in immature mice exposed to 17beta-estradiol, 1,1,1-trichloro-2, 2-bis(p-chlorophenyl)ethane, and methoxychlor. , 2000, American journal of obstetrics and gynecology.

[28]  Chisato Miyaura,et al.  Comparative Effects of Estrogen and Raloxifene on B Lymphopoiesis and Bone Loss Induced by Sex Steroid Deficiency in Mice , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[29]  J. Gustafsson,et al.  Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice. , 1999, The Journal of clinical investigation.

[30]  S. Cummings,et al.  The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation. , 1999, JAMA.

[31]  A. Silman,et al.  Oral contraceptives and rheumatoid arthritis: results from a primary care-based incident case-control study. , 1997, Seminars in arthritis and rheumatism.

[32]  R. Higgs,et al.  Advantages of raloxifene over alendronate or estrogen on nonreproductive and reproductive tissues in the long-term dosing of ovariectomized rats. , 1996, The Journal of pharmacology and experimental therapeutics.

[33]  H. Bryant,et al.  Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[34]  T. Spector,et al.  A randomised controlled trial of the effect of hormone replacement therapy on disease activity in postmenopausal rheumatoid arthritis. , 1994, Annals of the rheumatic diseases.

[35]  S. Ralston,et al.  Effects of hormone replacement therapy in rheumatoid arthritis: a double blind placebo-controlled study. , 1994, Annals of the rheumatic diseases.

[36]  A. Tarkowski,et al.  Histopathological and serological progression of experimental Staphylococcus aureus arthritis , 1992, Infection and immunity.

[37]  R. Holmdahl,et al.  Oestrogen induced suppression of collagen arthritis. IV: Progesterone alone does not affect the course of arthritis but enhances the oestrogen-mediated therapeutic effect. , 1989, Journal of reproductive immunology.

[38]  L. Aarden,et al.  Functional discrimination between interleukin 6 and interleukin 1 , 1988, European journal of immunology.

[39]  R. Holmdahl,et al.  Oestrogen‐Induced Suppression of Collagen Arthritis , 1987 .

[40]  J. Bijlsma,et al.  Effect of oestrogen treatment on clinical and laboratory manifestations of rheumatoid arthritis. , 1987, Annals of the rheumatic diseases.

[41]  R. Holmdahl,et al.  Female sex hormones suppress development of collagen-induced arthritis in mice. , 1986, Arthritis and rheumatism.

[42]  A. Kang,et al.  Autoimmunity to type II collagen an experimental model of arthritis , 1977, The Journal of experimental medicine.

[43]  Jens Holmberg,et al.  Positional identification of Ncf1 as a gene that regulates arthritis severity in rats , 2003, Nature Genetics.

[44]  O. Førre,et al.  The prevalence and severity of rheumatoid arthritis in Oslo. Results from a county register and a population survey. , 1997, Scandinavian journal of rheumatology.

[45]  D. Williams,et al.  Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. , 1994, The Journal of clinical investigation.

[46]  L. Klareskog,et al.  Homologous type II collagen induces chronic and progressive arthritis in mice. , 1986, Arthritis and rheumatism.