Cytotoxic activities of monoclonal antibodies against the envelope proteins of murine leukemia virus.

Monoclonal antibodies against the envelope proteins [gp70 and p15(E)] of murine leukemia virus react with the cell surface of virus-infected cells. The specificity and potency of these antibodies exceed those observed with conventional polyvalent antisera. In cytotoxic assays, certain of the monoclonal anti-gp70 antibodies demonstrate 1000-fold differences in their titer on leukemic and normal thymus cells.

[1]  I. Bernstein,et al.  Mouse leukemia: therapy with monoclonal antibodies against a thymus differentiation antigen. , 1980, Science.

[2]  W. N. Burnette,et al.  Monoclonal antibodies against murine leukemia viruses: identification of six antigenic determinants on the p 15(E) and gp70 envelope proteins. , 1979, Virology.

[3]  W. N. Burnette,et al.  The isolation of hybrid cell lines producing monoclonal antibodies against the p15(E) protein of ecotropic murine leukemia viruses. , 1979, Virology.

[4]  R. Eisenman,et al.  Biosynthesis and metabolism of viral proteins expressed on the surface of murine leukemia virus-infected cells. , 1978, Virology.

[5]  L. Old,et al.  Immunogenetics of cell surface antigens of mouse leukemia. , 1977, Annual review of genetics.

[6]  T. Doyle,et al.  Cellular changes in the thymuses of preleukemic AKR mice: Correlation with changes in the expression of murine leukemia viruses , 1977, Cell.

[7]  T. Doyle,et al.  Oncornaviruses produced by murine leukemia cells in culture. , 1977, Virology.

[8]  J. Ledbetter,et al.  Viral proteins expressed on the surface of murine leukemia cells , 1977, Journal of virology.

[9]  T. Yoshiki,et al.  A core polyprotein of murine leukemia virus on the surface of mouse leukemia cells , 1976, Cell.

[10]  J. Riggs,et al.  Induction of lymphoma and associated xenotropic type C virus in C57L mice by whole-body irradiation. , 1976, Journal of the National Cancer Institute.

[11]  C. Milstein,et al.  Derivation of specific antibody‐producing tissue culture and tumor lines by cell fusion , 1976, European journal of immunology.

[12]  V. Moennig,et al.  Properties of mouse leukemia viruses. X. Occurrence of viral structural antigens on the cell surface as revealed by a cytotoxicity test. , 1976, Virology.

[13]  C. Milstein,et al.  Continuous cultures of fused cells secreting antibody of predefined specificity , 1975, Nature.

[14]  L. Herzenberg,et al.  ANALYSIS OF CELL POPULATIONS WITH A FLUORESCENCE‐ACTIVATED CELL SORTER * , 1975, Annals of the New York Academy of Sciences.

[15]  E. Vitetta,et al.  Biochemical evidence linking the GIX thymocyte surface antigen to the gp69/71 envelope glycoprotein of murine leukemia virus , 1975, The Journal of experimental medicine.

[16]  R. Lerner,et al.  The oncornavirus glycoprotein gp69/71: a constituent of the surface of normal and malignant thymocytes , 1975, The Journal of experimental medicine.