Regulation of liver-specific steroid metabolizing cytochromes P450: Cholesterol 7α-hydroxylase, bile acid 6β-hydroxylase, and growth hormone-responsive steroid hormone hydroxylases

[1]  J. Gustafsson,et al.  The role and mechanism of growth hormone in the regulation of sexually dimorphic P450 enzymes in rat liver , 1992, The Journal of Steroid Biochemistry and Molecular Biology.

[2]  M. Negishi,et al.  Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: Steroid-binding site and orientation , 1992, The Journal of Steroid Biochemistry and Molecular Biology.

[3]  D. T. Molowa,et al.  Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene. , 1992, Biochemistry.

[4]  D. Waxman,et al.  Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone. , 1992, The Journal of biological chemistry.

[5]  D. Waxman,et al.  Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes. , 1992, The Journal of biological chemistry.

[6]  D. Waxman,et al.  Thyroid hormone stimulation of NADPH P450 reductase expression in liver and extrahepatic tissues. Regulation by multiple mechanisms. , 1992, The Journal of biological chemistry.

[7]  G. Everson,et al.  Regulation of cholesterol and bile acid homoeostasis in bile-obstructed rats. , 1991, The Biochemical journal.

[8]  M. Waters,et al.  The nuclear growth hormone receptor binding protein. Antigenic and physicochemical characterization. , 1991, The Journal of biological chemistry.

[9]  K. Clauser,et al.  Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. , 1991, Science.

[10]  G. Gil,et al.  Cloning, expression, and regulation of lithocholic acid 6 beta-hydroxylase. , 1991, The Journal of biological chemistry.

[11]  J. Gustafsson,et al.  A role for protein kinases in the growth hormone regulation of cytochrome P4502C12 and insulin-like growth factor-I messenger RNA expression in primary adult rat hepatocytes. , 1991, Molecular endocrinology.

[12]  P. Thomas,et al.  Evidence from dwarf rats that growth hormone may not regulate the sexual differentiation of liver cytochrome P450 enzymes and steroid 5 alpha-reductase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[13]  M. J. Coon,et al.  The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. , 1991, DNA and cell biology.

[14]  D. Russell,et al.  Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. , 1991, The Journal of biological chemistry.

[15]  O. Gotoh,et al.  Structural analysis of the gene encoding rat cholesterol alpha-hydroxylase, the key enzyme for bile acid biosynthesis. , 1991, The Journal of biological chemistry.

[16]  M. Straka,et al.  Activation of the silent endogenous cholesterol-7-alpha-hydroxylase gene in rat hepatoma cells: a new complementation group having resistance to 25-hydroxycholesterol , 1991, Molecular and cellular biology.

[17]  D. Waxman,et al.  Distinct forms of cytochrome P-450 are responsible for 6 beta-hydroxylation of bile acids and of neutral steroids. , 1991, The Biochemical journal.

[18]  P. Hylemon,et al.  Regulation of bile acid synthesis , 1991, Hepatology.

[19]  P. Hylemon,et al.  Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat. , 1991, The Journal of biological chemistry.

[20]  G. Ness,et al.  Regulation of cholesterol 7 alpha-hydroxylase by hepatic 7 alpha-hydroxylated bile acid flux and newly synthesized cholesterol supply. , 1991, The Journal of biological chemistry.

[21]  B. Cochran,et al.  Rapid events in growth hormone action. Induction of c-fos and c-jun transcription in 3T3-F442A preadipocytes. , 1990, Endocrinology.

[22]  A. Mode,et al.  Growth hormone (GH) regulation of cytochrome P-450IIC12, insulin-like growth factor-I (IGF-I), and GH receptor messenger RNA expression in primary rat hepatocytes: a hormonal interplay with insulin, IGF-I, and thyroid hormone. , 1990, Molecular endocrinology.

[23]  J. Chiang,et al.  Effect of thyroid hormone on hepatic cholesterol 7 alpha hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein A-I mRNA levels in hypophysectomized rats. , 1990, Biochemical and biophysical research communications.

[24]  J. Yoon,et al.  An inducible nuclear factor binds to a growth hormone-regulated gene. , 1990, The Journal of biological chemistry.

[25]  D. Waxman,et al.  Pretranslational control by thyroid hormone of rat liver steroid 5 alpha-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. , 1990, The Journal of biological chemistry.

[26]  R. Johnson,et al.  Growth hormone stimulates the formation of sn-1,2-diacylglycerol in rat hepatocytes. , 1990, Endocrinology.

[27]  E. Morgan,et al.  Transcriptional and post‐transcriptional suppression of P450IIC11 and P450IIC12 by inflammation , 1990, FEBS letters.

[28]  D. Waxman,et al.  Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response. , 1990, The Biochemical journal.

[29]  R. Kato,et al.  Modulation of hepatic level of microsomal testosterone 7 alpha-hydroxylase, P-450a (P450IIA), by thyroid hormone and growth hormone in rat liver. , 1990, Journal of biochemistry.

[30]  D. Waxman,et al.  Hepatic P-450 cholesterol 7 alpha-hydroxylase. Regulation in vivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback. , 1990, The Journal of biological chemistry.

[31]  D. Russell,et al.  Structure of the rat gene encoding cholesterol 7α-hydroxylase , 1990 .

[32]  M. Noshiro,et al.  Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7α‐hydroxylase , 1990 .

[33]  J. Chiang,et al.  Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA. , 1990, The Journal of biological chemistry.

[34]  M. Noshiro,et al.  Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational regulation for circadian rhythm. , 1990, The Journal of biological chemistry.

[35]  C. Slaughter,et al.  Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. , 1990, The Journal of biological chemistry.

[36]  Joseph Schlessinger,et al.  Signal transduction by receptors with tyrosine kinase activity , 1990, Cell.

[37]  M. Noshiro,et al.  Molecular cloning of cDNA for vitamin D3 25‐hydroxylase from rat liver mitochondria , 1990, FEBS letters.

[38]  D. Waxman,et al.  Pituitary regulation of the male-specific steroid 6 beta-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational leve;. , 1990, Molecular endocrinology.

[39]  J. Goldstein,et al.  Regulation of the mevalonate pathway , 1990, Nature.

[40]  D. Waxman,et al.  Hormonal regulation of levels of the messenger RNA encoding hepatic P450 2c (IIC11), a constitutive male-specific form of cytochrome P450. , 1990, Molecular endocrinology.

[41]  J. MacLeod,et al.  Depletion of serum growth hormone in adult female rats by neonatal monosodium glutamate treatment without loss of female-specific hepatic enzymes P450 2d (IIC12) and steroid 5 alpha-reductase. , 1990, Endocrinology.

[42]  E. Schuetz,et al.  Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane. , 1990, The Journal of biological chemistry.

[43]  H. Sasamura,et al.  Effect of growth hormone on rat hepatic cytochrome P-450f mRNA: a new mode of regulation , 1990, Molecular and Cellular Endocrinology.

[44]  T. Aoyama,et al.  Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine. , 1989, The Journal of biological chemistry.

[45]  J. MacLeod,et al.  Signalling elements in the ultradian rhythm of circulating growth hormone regulating expression of sex-dependent forms of hepatic cytochrome P450. , 1989, Endocrinology.

[46]  N. Ling,et al.  Identification of rat S14 protein and comparison of its regulation with that of mRNA S14 employing synthetic peptide antisera. , 1989, The Journal of biological chemistry.

[47]  J. Goldstein,et al.  Hormonal regulation of male-specific rat hepatic cytochrome P-450g (P-450IIC13) by androgens and the pituitary. , 1989, The Journal of biological chemistry.

[48]  J. Shafer,et al.  Phosphorylation of highly purified growth hormone receptors by a growth hormone receptor-associated tyrosine kinase. , 1989, The Journal of biological chemistry.

[49]  S. Imaoka,et al.  Suppression of hepatic levels of an ethanol-inducible P-450DM/j by growth hormone: relationship between the increased level of P-450DM/j and depletion of growth hormone in diabetes. , 1989, Molecular pharmacology.

[50]  T. Kronbach,et al.  Hybrid cytochromes P-450 identify a substrate binding domain in P-450IIC5 and P-450IIC4. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[51]  M. Noshiro,et al.  Molecular cloning of cDNA for cholesterol 7 alpha-hydroxylase from rat liver microsomes. Nucleotide sequence and expression. , 1989, FEBS letters.

[52]  Z. Hochberg,et al.  The dynamics of somatogenic and lactogenic growth hormone binding: internalization to Golgi fractions in the male rat. , 1989, Endocrinology.

[53]  Z. Hochberg,et al.  Adaptation of liver membrane somatogenic and lactogenic growth hormone (GH) binding to the spontaneous pulsation of GH secretion in the male rat. , 1989, Endocrinology.

[54]  J. Gustafsson,et al.  Transcriptional and posttranscriptional regulation of sexually differentiated rat liver cytochrome P-450 by growth hormone. , 1989, Molecular endocrinology.

[55]  T. Aoyama,et al.  Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. , 1989, The Journal of biological chemistry.

[56]  R. Lindberg,et al.  Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue , 1989, Nature.

[57]  L. Mathews,et al.  Regulation of rat growth hormone receptor gene expression. , 1989, The Journal of biological chemistry.

[58]  D. Waxman,et al.  Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms. , 1989, Endocrinology.

[59]  D. Waxman,et al.  Detoxification of lithocholic acid. Elucidation of the pathways of oxidative metabolism in rat liver microsomes. , 1989, Journal of lipid research.

[60]  D. Waxman,et al.  Hypophysectomy differentially alters P-450 protein levels and enzyme activities in rat liver: pituitary control of hepatic NADPH cytochrome P-450 reductase. , 1989, Molecular pharmacology.

[61]  J. Gustafsson,et al.  Regulation of sexual differentiation in drug and steroid metabolism. , 1989, Trends in pharmacological sciences.

[62]  C. Dani,et al.  Growth hormone stimulates c-fos gene expression by means of protein kinase C without increasing inositol lipid turnover. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[63]  A. Herington,et al.  Cellular mechanisms in the processing of growth hormone and its receptor , 1989, Molecular and Cellular Endocrinology.

[64]  J. Gustafsson,et al.  Sex change in cytochrome P-450 phenotype by growth hormone treatment of adult rat hepatocytes maintained in a culture system on matrigel. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[65]  S. Imaoka,et al.  A sex-specific form of cytochrome P-450 catalyzing propoxycoumarin O-depropylation and its identity with testosterone 6 beta-hydroxylase in untreated rat livers: reconstitution of the activity with microsomal lipids. , 1988, Journal of biochemistry.

[66]  J. Schenkman,et al.  Further characterization of RLM2 and comparison with a related form of cytochrome P-450, RLM2b. , 1988, Archives of biochemistry and biophysics.

[67]  T. Tanabe,et al.  Developmental changes of the content of acetyl-CoA carboxylase mRNA in chicken liver. , 1988, Archives of biochemistry and biophysics.

[68]  B. Bloch,et al.  Growth hormone-deficient dwarfism in the rat: a new mutation. , 1988, The Journal of endocrinology.

[69]  J. Kwekkeboom,et al.  Feedback inhibition of bile acid synthesis in cultured pig hepatocytes. , 1988, Biochemical and biophysical research communications.

[70]  J. Staunton,et al.  Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression. , 1988, The Journal of biological chemistry.

[71]  D. Waxman,et al.  Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme. , 1988, Archives of biochemistry and biophysics.

[72]  N. Javitt,et al.  Bile acid synthesis: down‐regulation by monohydroxy bile acids 1 , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[73]  M. Straka,et al.  Examination of bile acid negative feedback regulation in rats. , 1988, Journal of lipid research.

[74]  Y. Fujii‐Kuriyama,et al.  Gene structure of cytochrome P-450(M-1) specifically expressed in male rat liver. , 1987, Biochemistry.

[75]  William I. Wood,et al.  Growth hormone receptor and serum binding protein: purification, cloning and expression , 1987, Nature.

[76]  T. Kamataki,et al.  Further studies on the persistence of neonatal androgen imprinting on sex-specific cytochrome P-450, testosterone and drug oxidations. , 1987, Japanese journal of pharmacology.

[77]  D. Waxman,et al.  Cytochrome P-450 cholesterol 7 alpha-hydroxylase: inhibition of enzyme deactivation by structurally diverse calmodulin antagonists and phosphatase inhibitors. , 1987, Archives of biochemistry and biophysics.

[78]  T. Tephly,et al.  Glucuronidation of 6 alpha-hydroxy bile acids by human liver microsomes. , 1987, The Journal of clinical investigation.

[79]  T. Ogishima,et al.  Purification and characterization of cholesterol 7 alpha-hydroxylase from rat liver microsomes. , 1987, The Journal of biological chemistry.

[80]  R. Kato,et al.  Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. , 1987, The Journal of biological chemistry.

[81]  J. Goldstein,et al.  Phenotypic differences in expression of cytochrome P-450g but not its mRNA in outbred male Sprague-Dawley rats. , 1987, Archives of biochemistry and biophysics.

[82]  M. Noshiro,et al.  Pretranslational regulation of sex-dependent testosterone hydroxylases by growth hormone in mouse liver. , 1986, The Journal of biological chemistry.

[83]  T. Kamataki,et al.  Effect of growth hormone and ectopic transplantation of pituitary gland on sex-specific forms of cytochrome P-450 and testosterone and drug oxidations in rat liver. , 1986, Journal of biochemistry.

[84]  F. Gonzalez,et al.  Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA. , 1986, The Journal of biological chemistry.

[85]  D. Waxman,et al.  Hormonal regulation of rat liver microsomal enzymes. Role of gonadal steroids in programming, maintenance, and suppression of delta 4-steroid 5 alpha-reductase, flavin-containing monooxygenase, and sex-specific cytochromes P-450. , 1986, The Journal of biological chemistry.

[86]  P. Thomas,et al.  Age- and sex-related expression of cytochromes p450f and P450g in rat liver. , 1986, Archives of biochemistry and biophysics.

[87]  D. Nebert,et al.  Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation , 1986, Molecular and cellular biology.

[88]  D. Waxman Rat hepatic cholesterol 7 alpha-hydroxylase: biochemical properties and comparison to constitutive and xenobiotic-inducible cytochrome P-450 enzymes. , 1986, Archives of biochemistry and biophysics.

[89]  P. Hylemon,et al.  Absence of negative feedback control of bile acid biosynthesis in cultured rat hepatocytes. , 1985, The Journal of biological chemistry.

[90]  J. Gustafsson,et al.  Hypothalamo-Pituitary Regulation of Cytochrome P-45015β Apoprotein Levels in Rat Liver , 1985 .

[91]  J. Gustafsson,et al.  Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16 alpha-hydroxylase cytochrome P-450 apoprotein in the rat. , 1985, The Journal of biological chemistry.

[92]  D. Waxman,et al.  Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes. , 1985, Biochemistry.

[93]  J. Jansson,et al.  Sexual dimorphism in the control of growth hormone secretion. , 1985, Endocrine reviews.

[94]  J. Mittler Studies on the kinetics of the interaction of 7α-hydroxytestosterone with the steroid 5α-reductase , 1985, Steroids.

[95]  D. Waxman Rat hepatic cytochrome P-450 isoenzyme 2c. Identification as a male-specific, developmentally induced steroid 16 alpha-hydroxylase and comparison to a female-specific cytochrome P-450 isoenzyme. , 1984, The Journal of biological chemistry.

[96]  R. Baxter,et al.  Induction of hepatic receptors for growth hormone (GH) and prolactin by GH infusion is sex independent. , 1984, Endocrinology.

[97]  A. Sanghvi,et al.  Regulation of three key enzymes in cholesterol metabolism by phosphorylation/dephosphorylation. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[98]  J. Kuan,et al.  Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids. , 1983, The Journal of biological chemistry.

[99]  J. Gustafsson,et al.  Association between plasma level of growth hormone and sex differentiation of hepatic steroid metabolism in the rat. , 1982, Endocrinology.

[100]  J. B. Martin,et al.  Evidence that reduced growth hormone secretion observed in monosodium glutamate-treated rats is the result of a deficiency in growth hormone-releasing factor. , 1982, Endocrinology.

[101]  P. Saenger,et al.  6βHydroxy cortisol: A Noninvasive Indicator of Enzyme Induction* , 1981 .

[102]  A. Batta,et al.  Regulation of bile acid synthesis. Measurement of cholesterol 7 alpha-hydroxylase activity in rat liver microsomal preparations in the absence of endogenous cholesterol. , 1981, Journal of lipid research.

[103]  S. Venkatesan,et al.  On the mechanism for the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, of cholesterol 7alpha-hydroxylase and of acyl-coenzyme A:cholesterol acyltransferase by free cholesterol. , 1978, Biochimica et biophysica acta.

[104]  K. Mitropoulos,et al.  Cholesterol 7 alpha-hydroxylase. , 1977, Journal of lipid research.

[105]  J. Sjövall,et al.  Bile acid metabolism. , 1975, Annual review of biochemistry.

[106]  R. Rivlin,et al.  Effects of thyroxine upon biosynthesis of flavin mononucleotide and flavin adenine dinucleotide. , 1969, Endocrinology.

[107]  D. Waxman Rat hepatic P450IIA and P450IIC subfamily expression using catalytic, immunochemical, and molecular probes. , 1991, Methods in enzymology.

[108]  D. Waxman,et al.  Hepatic P450 expression in hypothyroid rats: differential responsiveness of male-specific P450 forms 2a (IIIA2), 2c (IIC11), and RLM2 (IIA2) to thyroid hormone. , 1991, Molecular endocrinology.

[109]  Z. Hochberg,et al.  Alterations of human growth hormone binding by rat liver membranes during hypo- and hyperthyroidism. , 1990, Endocrinology.

[110]  W. Levin,et al.  Purification and characterization of hepatic microsomal cytochrome P-450. , 1990, Pharmacology & therapeutics.

[111]  J. Schenkman,et al.  Effects of testosterone and growth hormone treatment on hepatic microsomal P450 expression in the diabetic rat. , 1990, Molecular pharmacology.

[112]  J. Gustafsson,et al.  Structural and regulatory analysis of a cytochrome P450 gene (CYP2C12) expressed predominantly in female rat liver. , 1990, DNA and cell biology.

[113]  H. Samuels,et al.  Regulation of gene expression by thyroid hormone. , 1988, The Journal of clinical investigation.

[114]  D. Waxman Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression. , 1988, Biochemical pharmacology.

[115]  P. Skett Hormonal regulation and sex differences of xenobiotic metabolism , 1987 .

[116]  A. Arnold,et al.  Gonadal steroid induction of structural sex differences in the central nervous system. , 1984, Annual review of neuroscience.

[117]  J. Gustafsson,et al.  Sex steroid induced changes in hepatic enzymes. , 1983, Annual review of physiology.

[118]  B. Tuchweber,et al.  Bile acid composition in neonatal life in rats. , 1982, Biology of the neonate.

[119]  J. Olney Excitatory neurotoxins as food additives: an evaluation of risk. , 1981, Neurotoxicology.

[120]  R. Kato,et al.  Sex-related differences in drug metabolism. , 1974, Drug metabolism reviews.

[121]  Keiko Suzuki,et al.  Biological Activities of 7±-Hydroxylated C19-Steroids and Changes in Rat Testicular 7±-Hydroxylase Activity with Gonadal Status , 1973 .