Shift-multiplexing complex spectral-domain optical coherence tomography

Abstract. We propose and experimentally demonstrate a shift-multiplexing complex spectral-domain optical coherence tomography (shift-multiplexing CSD-OCT) method, in which the maximum detection depth of SD-OCT can be greatly extended by incorporating the shift-multiplexing of detection positions with CSD-OCT. The tomographic imaging with twofold or threefold microscopic slides as the target sample is performed. The experimental results show that the tomographic imaging with more uniform brightness and clarity for the different depth regions in a thick sample can be achieved by the shift-multiplexing CSD-OCT system. In particular, even while the sample’s depth is beyond the maximum imaging depth of CSD-OCT system, the tomographic imaging of this sample can still be realized by using the shift-multiplexing CSD-OCT method without the need for any replacement of the equipment, such as high spectral capacity grating or high resolution of CCD. The shift-multiplexing CSD-OCT system can perform the imaging with the optimization and less reduction of sensitivity for the deeper detection position in the sample.

[1]  R. Leitgeb,et al.  High speed full range complex spectral domain optical coherence tomography. , 2005, Optics express.

[2]  A. Fercher,et al.  Full range complex spectral optical coherence tomography technique in eye imaging. , 2002, Optics letters.

[3]  J. D. de Boer,et al.  Phase-stabilized optical frequency domain imaging at 1-µm for the measurement of blood flow in the human choroid. , 2011, Optics Express.

[4]  Risto Myllylä,et al.  Complex Conjugate Resolved Retinal Imaging by One-micrometer Spectral Domain Optical Coherence Tomography Using an Electro-optical Phase Modulator , 2011 .

[5]  M. Wojtkowski,et al.  Flow velocity estimation using joint Spectral and Time domain Optical Coherence Tomography. , 2008, Optics express.

[6]  Michael Pircher,et al.  Sample motion-insensitive, full-range, complex, spectral-domain optical-coherence tomography. , 2010, Optics letters.

[7]  Kai Wang,et al.  Time-domain interpolation for Fourier-domain optical coherence tomography. , 2009, Optics letters.

[8]  Wooyoung Jang,et al.  Complex wavefront shaping for optimal depth-selective focusing in optical coherence tomography. , 2013, Optics express.

[9]  A. Fercher,et al.  Performance of fourier domain vs. time domain optical coherence tomography. , 2003, Optics express.

[10]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[11]  Joseph A Izatt,et al.  High-speed complex conjugate resolved retinal spectral domain optical coherence tomography using sinusoidal phase modulation. , 2007, Optics letters.

[12]  A. Fercher,et al.  Phase-shifting algorithm to achieve high-speed long-depth-range probing by frequency-domain optical coherence tomography. , 2003, Optics letters.

[13]  Q. Ren,et al.  Evaluation of spectrometric parameters in spectral-domain optical coherence tomography. , 2011, Applied optics.

[14]  Kang Zhang,et al.  Full-range Fourier domain optical coherence tomography imaging probe with a magnetic-driven resonant fiber cantilever , 2011 .

[15]  Maciej Wojtkowski,et al.  Complex spectral OCT in human eye imaging in vivo , 2004 .

[17]  Anna Szkulmowska,et al.  Flow velocity estimation by complex ambiguity free joint Spectral and Time domain Optical Coherence Tomography. , 2009, Optics express.

[18]  Zhijia Yuan,et al.  Increasing the imaging depth of spectral-domain OCT by using interpixel shift technique. , 2006, Optics express.

[19]  Zhihua Ding,et al.  High-resolution optical coherence tomography over a large depth range with an axicon lens. , 2002, Optics letters.

[20]  Ruikang K. Wang,et al.  High-resolution 1050 nm spectral domain retinal optical coherence tomography at 120 kHz A-scan rate with 6.1 mm imaging depth , 2013, Biomedical optics express.

[21]  Michael Pircher,et al.  Full range complex spectral domain optical coherence tomography without additional phase shifters. , 2007, Optics express.

[22]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991, LEOS '92 Conference Proceedings.

[23]  Experimental demonstration of high-speed full-range Fourier domain optical coherence tomography imaging using orthogonally polarized light and a phase-shifting algorithm. , 2012, Applied optics.

[24]  O. Sasaki,et al.  Dynamic full-range Fourier-domain optical coherence tomography using sinusoidal phase-modulating interferometry , 2007 .

[25]  Maciej Szkulmowski,et al.  Averaging techniques for OCT imaging. , 2013, Optics express.