Basic Aspects of Allergy and Hypersensitivity Reactions

Key players within immunologically mediated hypersensitivity reactions are allergen-specific IgE or IgG antibodies, immune complexes, or lymphocytes. According to these diverse pathophysiological mechanisms behind the clinical appearance, hypersensitivity reactions are classified into type I through IV. The focus of this chapter lies on the characterization of type I, i.e. IgE-mediated reactions.

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