Consciousness In The Universe

The nature of consciousness, the mechanism by which it occurs in the brain, and its ultimate place in the universe are unknown. We proposed in the mid 1990's that consciousness depends on biologically 'orchestrated' coherent quantum processes in collections of microtubules within brain neurons, that these quantum processes correlate with, and regulate, neuronal synaptic and membrane activity, and that the continuous Schrodinger evolution of each such process terminates in accordance with the specific Diosi-Penrose (DP) scheme of 'objective reduction' ('OR') of the quantum state. This orchestrated OR activity ('Orch OR') is taken to result in moments of conscious awareness and/or choice. The DP form of OR is related to the fundamentals of quantum mechanics and space-time geometry, so Orch OR suggests that there is a connection between the brain's biomolecular processes and the basic structure of the universe. Here we review Orch OR in light of criticisms and developments in quantum biology, neuroscience, physics and cosmology. We also introduce a novel suggestion of 'beat frequencies' of faster microtubule vibrations as a possible source of the observed electro-encephalographic ('EEG') correlates of consciousness. We conclude that consciousness plays an intrinsic role in the universe.

[1]  W. James,et al.  The Principles of Psychology. , 1983 .

[2]  T. Huxley Method and results , 1901 .

[3]  C. Sherrington Man On His Nature , 1940 .

[4]  F. Attneave,et al.  The Organization of Behavior: A Neuropsychological Theory , 1949 .

[5]  K. Maccorquodale Organization of Behavior : A Neuropsychological Theory , 1951 .

[6]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1952, The Journal of physiology.

[7]  H. Everett "Relative State" Formulation of Quantum Mechanics , 1957 .

[8]  A. A. Mullin,et al.  Principles of neurodynamics , 1962 .

[9]  F. Károlyházy,et al.  Gravitation and quantum mechanics of macroscopic objects , 1966 .

[10]  J. M. Stroud THE FINE STRUCTURE OF PSYCHOLOGICAL TIME , 1967 .

[11]  B. Pontecorvo Neutrino Experiments and the Problem of Conservation of Leptonic Charge , 1967 .

[12]  H. Fröhlich Long-range coherence and energy storage in biological systems , 1968 .

[13]  H. Fröhlich Long Range Coherence and the Action of Enzymes , 1970, Nature.

[14]  J. Atema,et al.  Microtube theory of sensory transduction. , 1973, Journal of theoretical biology.

[15]  A. Klug,et al.  Arrangement of subunits in flagellar microtubules. , 1974, Journal of cell science.

[16]  F. Károlyházy Gravitation and quantum mechanics of macroscopic bodies , 1974 .

[17]  H. Fröhlich,et al.  The extraordinary dielectric properties of biological materials and the action of enzymes. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[18]  B. Libet,et al.  Subjective Referral of the Timing for a Conscious Sensory Experience , 1979 .

[19]  B. Libet,et al.  Subjective referral of the timing for a conscious sensory experience: a functional role for the somatosensory specific projection system in man. , 1979, Brain : a journal of neurology.

[20]  S. Edelstein,et al.  Evidence for a mixed lattice in microtubules reassembled in vitro. , 1980, Journal of molecular biology.

[21]  R. Forward Dragon's Egg , 1980 .

[22]  T. Kibble Is a Semi-Classical Theory of Gravity Viable? , 1981 .

[23]  Alastair I M Rae,et al.  Quantum Mechanics , 1981 .

[24]  R C Watt,et al.  Information processing in microtubules. , 1982, Journal of theoretical biology.

[25]  P. Benioff Quantum mechanical hamiltonian models of turing machines , 1982 .

[26]  General anesthetics directly inhibit electron mobility: dipole dispersion theory of anesthetic action. , 1982, Physiological chemistry and physics.

[27]  S. Hameroff,et al.  Do anesthetics act by altering electron mobility? , 1983, Anesthesia and Analgesia.

[28]  Dan Monroe,et al.  Biochemistry, 2nd edition: by Frank B. Armstrong, Oxford University Press, 1983. £24.50 (xxv + 653 pages) ISBN 0 195 03109 1 (£9.95 paper back 0 198 55178 9) , 1983 .

[29]  M. Kirschner,et al.  Dynamic instability of microtubule growth , 1984, Nature.

[30]  S. Hameroff,et al.  Cellular automata in cytoskeletal lattices , 1984 .

[31]  D. Deutsch Quantum theory, the Church–Turing principle and the universal quantum computer , 1985, Proceedings of the Royal Society of London. A. Mathematical and Physical Sciences.

[32]  Weber,et al.  Unified dynamics for microscopic and macroscopic systems. , 1986, Physical review. D, Particles and fields.

[33]  J. Barrow,et al.  The Anthropic Cosmological Principle , 1987 .

[34]  R. Feynman Quantum mechanical computers , 1986 .

[35]  Lajos Diósi,et al.  A universal master equation for the gravitational violation of quantum mechanics , 1987 .

[36]  J. Bell,et al.  Speakable and Unspeakable in Quatum Mechanics , 1988 .

[37]  Pearle,et al.  Combining stochastic dynamical state-vector reduction with spontaneous localization. , 1989, Physical review. A, General physics.

[38]  A. Zeilinger,et al.  Speakable and Unspeakable in Quantum Mechanics , 1989 .

[39]  S. Matsuyama,et al.  Hypothesis: microtubules, a key to Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[40]  W. Singer,et al.  Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[41]  R. Penrose The emperor's new mind: concerning computers, minds, and the laws of physics , 1989 .

[42]  Diósi,et al.  Models for universal reduction of macroscopic quantum fluctuations. , 1989, Physical review. A, General physics.

[43]  W. Pitts,et al.  A Logical Calculus of the Ideas Immanent in Nervous Activity (1943) , 2021, Ideas That Created the Future.

[44]  Drew McDermott,et al.  A critique of pure reason 1 , 1987, The Philosophy of Artificial Intelligence.

[45]  C. Koch,et al.  Towards a neurobiological theory of consciousness , 1990 .

[46]  Grassi,et al.  Continuous-spontaneous-reduction model involving gravity. , 1989, Physical review. A, Atomic, molecular, and optical physics.

[47]  Steen Rasmussen,et al.  Computational connectionism within neurons: a model of cytoskeletal automata subserving neural networks , 1990 .

[48]  G. Bensimon,et al.  Microtubule disruption and cognitive defects: Effect of colchicine on learning behavior in rats , 1991, Pharmacology Biochemistry and Behavior.

[49]  D. Dennett,et al.  The Nature of Consciousness , 2006 .

[50]  Charles H. Bennett,et al.  Communication via one- and two-particle operators on Einstein-Podolsky-Rosen states. , 1992, Physical review letters.

[51]  J. Eccles Evolution of consciousness. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[52]  R. Penrose Gravity and quantum mechanics , 1993 .

[53]  Abner Shimony,et al.  Search For A Naturalistic World View , 1993 .

[54]  N. Hirokawa,et al.  Direct visualization of the microtubule lattice seam both in vitro and in vivo , 1994, The Journal of cell biology.

[55]  Pearle,et al.  Bound state excitation, nucleon decay experiments and models of wave function collapse. , 1994, Physical review letters.

[56]  I. Percival Primary state diffusion , 1994, Proceedings of the Royal Society of London. Series A: Mathematical and Physical Sciences.

[57]  Jack A. Tuszynski,et al.  Ferroelectric behavior in microtubule dipole lattices: Implications for information processing, signaling and assembly/disassembly* , 1995 .

[58]  E. Wigner Remarks on the Mind-Body Question , 1995 .

[59]  Alexander von Rospatt,et al.  The Buddhist doctrine of momentariness: A survey of the origins and early phase of this doctrine up to Vasubandhu , 1995 .

[60]  E. Mandelkow,et al.  The microtubule lattice--dynamic instability of concepts. , 1995, Trends in cell biology.

[61]  Roger Penrose,et al.  What 'gaps'? Reply to Grush and Churchland , 1995 .

[62]  N. Eldredge,et al.  What Is Life , 1995 .

[63]  D. Dennett Darwin's Dangerous Idea: Evolution and the Meanings of Life , 1995 .

[64]  A. Scott Stairway to the Mind , 1995, Springer New York.

[65]  Rick Grush,et al.  Gaps in Penrose's toiling , 1995 .

[66]  Quantum spacetime fluctuations and primary state diffusion , 1995, Proceedings of the Royal Society of London. Series A: Mathematical and Physical Sciences.

[67]  R. Penrose On Gravity's role in Quantum State Reduction , 1996 .

[68]  G M Shepherd,et al.  The dendritic spine: a multifunctional integrative unit. , 1996, Journal of neurophysiology.

[69]  D. Chalmers The conscious mind: in search of a fundamental theory , 1996 .

[70]  Roger Penrose,et al.  Orchestrated Objective Reduction of Quantum Coherence in Brain Microtubules: The "Orch OR" Model for Consciousness , 1996 .

[71]  Alwyn C. Scott,et al.  Toward a science of consciousness: The first Tucson discussions and debates , 1996 .

[72]  R. Penrose,et al.  Conscious Events as Orchestrated Space-Time Selections , 1996 .

[73]  L. Turin,et al.  A spectroscopic mechanism for primary olfactory reception. , 1996, Chemical senses.

[74]  Roger Penrose,et al.  Orchestrated reduction of quantum coherence in brain microtubules: a model for consciousness , 1996 .

[75]  H. Weinfurter,et al.  Experimental quantum teleportation , 1997, Nature.

[76]  D. Radin,et al.  Anomalous Anticipatory Response on Randomized Future Conditions , 1997, Perceptual and motor skills.

[77]  L. Smolin,et al.  The Life of the Cosmos , 1997 .

[78]  Stuart R Hameroff,et al.  `Funda-Mentality': is the conscious mind subtly linked to a basic level of the universe? , 1998, Trends in Cognitive Sciences.

[79]  Paul Benioff QUANTUM ROBOTS AND ENVIRONMENTS , 1998 .

[80]  P. Hawrylak,et al.  Dielectric polarization, electrical conduction, information processing and quantum computation in microtubules. Are they plausible? , 1998, Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[81]  A. Fourest-Lieuvin,et al.  STOP Proteins are Responsible for the High Degree of Microtubule Stabilization Observed in Neuronal Cells , 1998, The Journal of cell biology.

[82]  S. Hameroff,et al.  Anesthesia, consciousness and hydrophobic pockets--a unitary quantum hypothesis of anesthetic action. , 1998, Toxicology letters.

[83]  S. Hameroff Quantum computation in brain microtubules? The Penrose-Hameroff 'Orch OR' model of consciousness , 1998 .

[84]  R. Traub,et al.  Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro , 1998, Nature.

[85]  Irene M. Moroz,et al.  Spherically symmetric solutions of the Schrodinger-Newton equations , 1998 .

[86]  R. Dermietzel,et al.  Gap junction wiring: a `new' principle in cell-to-cell communication in the nervous system? 1 Published on the World Wide Web on 4 November 1997. 1 , 1998, Brain Research Reviews.

[87]  J. Tuszynski,et al.  Mössbauer effect as a possible tool in detecting nonlinear excitations in microtubules , 1998 .

[88]  Christoph von der Malsburg,et al.  The What and Why of Binding The Modeler’s Perspective , 1999, Neuron.

[89]  Christoph von der Malsburg,et al.  The What and Why of Binding: Review The Modeler's Perspective , 1999 .

[90]  D. Debanne,et al.  The role of dendritic filtering in associative long-term synaptic plasticity. , 1999, Learning & memory.

[91]  T. Kosaka,et al.  Gap Junctions Linking the Dendritic Network of GABAergic Interneurons in the Hippocampus , 2000, The Journal of Neuroscience.

[92]  R. Penrose WAVEFUNCTION COLLAPSE AS A REAL GRAVITATIONAL EFFECT , 2000 .

[93]  Max Tegmark,et al.  The importance of quantum decoherence in brain processes , 1999, ArXiv.

[94]  How to know God : the soul's journey into the mystery of mysteries , 2000 .

[95]  T. Nakagaki,et al.  Intelligence: Maze-solving by an amoeboid organism , 2000, Nature.

[96]  Jiří Hašek,et al.  ELECTROMAGNETIC ACTIVITY OF YEAST CELLS IN THE M PHASE , 2001 .

[97]  Nancy J. Woolf,et al.  A quantum approach to visual consciousness , 2001, Trends in Cognitive Sciences.

[98]  W. Zakrzewski,et al.  Electron self-trapping in a discrete two-dimensional lattice , 2001 .

[99]  Bartlett W. Mel,et al.  Impact of Active Dendrites and Structural Plasticity on the Memory Capacity of Neural Tissue , 2001, Neuron.

[100]  S. Hestrin,et al.  Electrical synapses between Gaba-Releasing interneurons , 2001, Nature Reviews Neuroscience.

[101]  John Polkinghorne,et al.  Quantum Theory: A Very Short Introduction , 2002 .

[102]  R. Traub,et al.  Axonal Gap Junctions Between Principal Neurons: A Novel Source of Network Oscillations, and Perhaps Epileptogenesis , 2002, Reviews in the neurosciences.

[103]  S. Hameroff,et al.  Quantum computation in brain microtubules: decoherence and biological feasibility. , 2000, Physical review. E, Statistical, nonlinear, and soft matter physics.

[104]  D. Wegner The Illusion of Conscious Will , 2018, The MIT Press.

[105]  W. Singer,et al.  Oscillatory Neuronal Synchronization in Primary Visual Cortex as a Correlate of Stimulus Selection , 2002, The Journal of Neuroscience.

[106]  Jack Tuszynski,et al.  Conduction pathways in microtubules, biological quantum computation, and consciousness. , 2002, Bio Systems.

[107]  Christoph Simon,et al.  Towards quantum superpositions of a mirror , 2004 .

[108]  C. Koch,et al.  Is perception discrete or continuous? , 2003, Trends in Cognitive Sciences.

[109]  N. Gisin,et al.  Long-distance teleportation of qubits at telecommunication wavelengths , 2003, Nature.

[110]  D. Awschalom,et al.  Coherent Spin Transfer Between Molecularly Bridged Quantum Dots , 2003, Science.

[111]  J. Pokorný,et al.  Excitation of vibrations in microtubules in living cells. , 2004, Bioelectrochemistry.

[112]  M. Eckenhoff,et al.  Inhalational Anesthetic-binding Proteins in Rat Neuronal Membranes* , 2004, Journal of Biological Chemistry.

[113]  M. Bennett,et al.  Electrical Coupling and Neuronal Synchronization in the Mammalian Brain , 2004, Neuron.

[114]  G. Tononi An information integration theory of consciousness , 2004, BMC Neuroscience.

[115]  A. Lutz,et al.  Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[116]  C. Koch The quest for consciousness : a neurobiological approach , 2004 .

[117]  E. Schrödinger Die gegenwärtige Situation in der Quantenmechanik , 1935, Naturwissenschaften.

[118]  Sisir Roy,et al.  Quantum entanglement of K+ ions, multiple channel states, and the role of noise in the brain , 2005, SPIE International Symposium on Fluctuations and Noise.

[119]  Roger Penrose,et al.  A complete guide to the laws of the universe , 2005 .

[120]  Stuart R. Hameroff,et al.  The Entwined Mysteries of Anesthesia and Consciousness: Is There a Common Underlying Mechanism? , 2006, Anesthesiology.

[121]  S. Hameroff Consciousness, Neurobiology and Quantum Mechanics: The Case for a Connection , 2006 .

[122]  C. Koch,et al.  Quantum mechanics in the brain , 2006, Nature.

[123]  M. Volgushev,et al.  Unique features of action potential initiation in cortical neurons , 2006, Nature.

[124]  T. Mančal,et al.  Evidence for wavelike energy transfer through quantum coherence in photosynthetic systems , 2007, Nature.

[125]  R. Malach The measurement problem in consciousness research , 2007, Behavioral and Brain Sciences.

[126]  N. Block Consciousness, accessibility, and the mesh between psychology and neuroscience , 2007, Behavioral and Brain Sciences.

[127]  T. Huxley Method and Results, Essays , 2007 .

[128]  Stuart R. Hameroff,et al.  The Brain Is Both Neurocomputer and Quantum Computer , 2007, Cogn. Sci..

[129]  M. Eckenhoff,et al.  Halothane binding proteome in human brain cortex. , 2007, Journal of proteome research.

[130]  W. James The Principles of Psychology, Vol. I , 2008 .

[131]  Laura K. McKemmish,et al.  Weak, strong, and coherent regimes of Fröhlich condensation and their applications to terahertz medicine and quantum consciousness , 2009, Proceedings of the National Academy of Sciences.

[132]  Alan E Mark,et al.  Penrose-Hameroff orchestrated objective-reduction proposal for human consciousness is not biologically feasible. , 2009, Physical review. E, Statistical, nonlinear, and soft matter physics.

[133]  R. Penrose Black holes, quantum theory and cosmology , 2009 .

[134]  J. Hagan,et al.  Fluoxetine administration modulates the cytoskeletal microtubular system in the rat hippocampus , 2009, Synapse.

[135]  Remarks on the Number of Tubulin Dimers Per Neuron and Implications for Hameroff-Penrose Orch OR , 2009 .

[136]  Edward T. Bullmore,et al.  Broadband Criticality of Human Brain Network Synchronization , 2009, PLoS Comput. Biol..

[137]  Biyu J. He,et al.  The Temporal Structures and Functional Significance of Scale-free Brain Activity , 2010, Neuron.

[138]  Elisabeth Rieper,et al.  Quantum entanglement between the electron clouds of nucleic acids in DNA , 2010, 1006.4053.

[139]  S. Hameroff,et al.  The “conscious pilot”—dendritic synchrony moves through the brain to mediate consciousness , 2009, Journal of biological physics.

[140]  Vahe G. Gurzadyan,et al.  Concentric circles in WMAP data may provide evidence of violent pre-Big-Bang activity , 2010, 1011.3706.

[141]  J. Trojanowski,et al.  Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy , 2010, The Journal of Neuroscience.

[142]  Carsten Janke,et al.  Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton , 2010, Trends in Neurosciences.

[143]  D. Bem Feeling the future: experimental evidence for anomalous retroactive influences on cognition and affect. , 2011, Journal of personality and social psychology.

[144]  R. Penrose Cycles of time : an extraordinary new view of the universe , 2011 .

[145]  J. Trojanowski,et al.  The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. , 2011, Pharmacological research.

[146]  Henry P. Stapp,et al.  Mindful Universe: Quantum Mechanics and the Participating Observer , 2011 .

[147]  Roger Penrose,et al.  Consciousness in the Universe: Neuroscience, Quantum Space-Time Geometry and Orch OR Theory , 2011 .

[148]  L. Luo,et al.  Temperature Dependence of Protein Folding Deduced from Quantum Transition , 2011, 1102.3748.

[149]  J. Orenstein,et al.  From a Single-Band Metal to a High-Temperature Superconductor via Two Thermal Phase Transitions , 2011, Science.

[150]  Evidence of a new quantum state of nano-confined water , 2011, 1101.4994.

[151]  J. Morton,et al.  Sustained quantum coherence and entanglement in the avian compass. , 2009, Physical review letters.

[152]  S. Hameroff,et al.  Computational Predictions of Volatile Anesthetic Interactions with the Microtubule Cytoskeleton: Implications for Side Effects of General Anesthesia , 2012, PloS one.

[153]  Stuart Hameroff,et al.  How quantum brain biology can rescue conscious free will , 2012, Front. Integr. Neurosci..

[154]  Jack A. Tuszynski,et al.  Correction: The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease , 2012, PLoS ONE.

[155]  Rupert Ursin,et al.  Experimental delayed-choice entanglement swapping , 2012 .

[156]  Andrew Adamatzky,et al.  Slime mould computes planar shapes , 2011, Int. J. Bio Inspired Comput..

[157]  Jack A. Tuszynski,et al.  Cytoskeletal Signaling: Is Memory Encoded in Microtubule Lattices by CaMKII Phosphorylation? , 2012, PLoS Comput. Biol..

[158]  Jack A. Tuszynski,et al.  The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease , 2012, PloS one.

[159]  Xiaosong Ma,et al.  Quantum teleportation over 143 kilometres using active feed-forward , 2012, Nature.

[160]  J. Duhamel,et al.  Differential effects of parietal and frontal inactivations on reaction times distributions in a visual search task , 2012, Front. Integr. Neurosci..

[161]  David J. Chalmers,et al.  Constructing the World , 2012 .

[162]  S. Hameroff,et al.  Transcranial Ultrasound (TUS) Effects on Mental States: A Pilot Study , 2013, Brain Stimulation.

[163]  Javier Prior,et al.  The role of non-equilibrium vibrational structures in electronic coherence and recoherence in pigment–protein complexes , 2013, Nature Physics.