Gout-associated uric acid crystals activate the NALP3 inflammasome

[1]  R. Terkeltaub,et al.  Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. , 2005, Arthritis and rheumatism.

[2]  D. Kastner,et al.  Familial autoinflammatory diseases: genetics, pathogenesis and treatment , 2005, Current opinion in rheumatology.

[3]  N. Dalbeth,et al.  Mechanisms of inflammation in gout. , 2005, Rheumatology.

[4]  F. Martinon,et al.  NLRs join TLRs as innate sensors of pathogens. , 2005, Trends in immunology.

[5]  C. Dinarello.  Blocking IL-1 in systemic inflammation , 2005, The Journal of experimental medicine.

[6]  G. Firestein,et al.  Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist , 2004, The Lancet.

[7]  F. Martinon,et al.  Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome , 2004, Current Biology.

[8]  S. Akira,et al.  ASC is essential for LPS‐induced activation of procaspase‐1 independently of TLR‐associated signal adaptor molecules , 2004, Genes to cells : devoted to molecular & cellular mechanisms.

[9]  V. Dixit,et al.  Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf , 2004, Nature.

[10]  F. Martinon,et al.  Inflammatory Caspases Linking an Intracellular Innate Immune System to Autoinflammatory Diseases , 2004, Cell.

[11]  F. Martinon,et al.  NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. , 2004, Immunity.

[12]  D. Kastner,et al.  Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[13]  James E. Evans,et al.  Molecular identification of a danger signal that alerts the immune system to dying cells , 2003, Nature.

[14]  P. Hawkins,et al.  Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. , 2003, The New England journal of medicine.

[15]  D. Kastner,et al.  Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. , 2003, Molecular cell.

[16]  F. Martinon,et al.  New insights into the mechanism of IL-1β maturation , 2003 .

[17]  F. Martinon,et al.  NALPs: a novel protein family involved in inflammation , 2003, Nature Reviews Molecular Cell Biology.

[18]  F. Martinon,et al.  The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. , 2002, Molecular cell.

[19]  Y. Molad.  Update on colchicine and its mechanism of action , 2002, Current rheumatology reports.

[20]  P. Matzinger.  The Danger Model: A Renewed Sense of Self , 2002, Science.

[21]  C. Janeway,et al.  Innate immune recognition. , 2002, Annual review of immunology.

[22]  R. Kolodner,et al.  Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome , 2001, Nature Genetics.

[23]  D. Kastner,et al.  TNFRSF1A mutations and autoinflammatory syndromes. , 2000, Current opinion in immunology.

[24]  A. Hudson,et al.  Monosodium urate, hydroxyapatite, and calcium pyrophosphate crystals induce tumor necrosis factor-alpha expression in a mononuclear cell line. , 1997, The Journal of rheumatology.

[25]  R. Médicis,et al.  Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. , 1997, The Journal of pharmacology and experimental therapeutics.

[26]  F. Jamar,et al.  Endothelial activation in monosodium urate monohydrate crystal-induced inflammation: in vitro and in vivo studies on the roles of tumor necrosis factor alpha and interleukin-1. , 1997, Arthritis and rheumatism.

[27]  J J Padgett,et al.  A renewed sense of self. , 1994, Journal of psychosocial nursing and mental health services.

[28]  R. Howell,et al.  Suppression of metabolic accompaniments of phagocytosis by colchicine. , 1965, Arthritis and rheumatism.

[29]  S. Malawista,et al.  THE EFFECT OF PRETREATMENT WITH COLCHICINE ON THE INFLAMMATORY RESPONSE TO MICROCRYSTALLINE URATE: A MODEL FOR GOUTY INFLAMMATION. , 1965, Annals of internal medicine.

[30]  D. Mccarty,et al.  ACUTE ARTHRITIS IN MAN AND DOG AFTER INTRASYNOVIAL INJECTION OF SODIUM URATE CRYSTALS , 1962 .