Biological effects of millimeter-wave radiation: A high-throughput screening system

This paper reports on the design and evaluation of a high-throughput assay system for investigating the biological effects of microwave/millimeter wave radiation. The approach presented here differs significantly from others with the deployment of a continuous culture device and sample handling technology that allows the rapid presentation of test samples in a uniform physiological state. Segmented flow of the sample passes through a fundamental mode millimeter-wave exposure cell that is, in this prototype, well characterized between 26 and 40 GHz. A sensitive bioluminescence-based reporter monitored the temporal evolution in each assay segment using optical detector arrays mounted at three observation points, i.e., before the sample entered the cell and during millimeter-wave exposure and postexposure. Using this approach, the continuous monitoring of bioluminescence may be used on different time scales to measure cell energy metabolism, gene expression and growth. Exposed and control samples were monito...

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