Decrease of Deleted in Malignant Brain Tumour‐1 (DMBT‐1) expression is a crucial late event in intrahepatic cholangiocarcinoma

Aims:  To investigate the participation of DMBT‐1, a candidate tumour suppressor gene, in the development of intrahepatic cholangiocarcinoma via intraductal papillary neoplasm of the liver (IPN‐L) arising in hepatolithiasis. DMBT‐1 plays a role in mucosal immune defence.

[1]  T. Terada,et al.  Glandular elements around the intrahepatic bile ducts in man; their morphology and distribution in normal livers. , 2008, Liver.

[2]  A. Poustka,et al.  Deleted in Malignant Brain Tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer. , 2001, Cancer research.

[3]  Y. Jan,et al.  Intraductal papillary neoplasia of the liver associated with hepatolithiasis , 2001, Hepatology.

[4]  L. Thim,et al.  Isolation and characterization of putative trefoil peptide receptors , 2000, Regulatory Peptides.

[5]  H. S. Kim,et al.  Somatic mutations of the trefoil factor family 1 gene in gastric cancer. , 2000, Gastroenterology.

[6]  A. Poustka,et al.  DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer. , 2000, Cancer research.

[7]  A. Sakurada,et al.  Expression of the DMBT1 Gene Is Frequently Suppressed in Human Lung Cancer , 1999, Japanese journal of cancer research : Gann.

[8]  J. Minna,et al.  Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer. , 1999, Cancer research.

[9]  K. Mafune,et al.  Lack of DMBT1 expression in oesophageal, gastric and colon cancers , 1999, British Journal of Cancer.

[10]  Y. Kim,et al.  Expression of apomucins in the intrahepatic biliary tree in hepatolithiasis differs from that in normal liver and extrahepatic biliary obstruction , 1998, Hepatology.

[11]  Jan Mollenhauer,et al.  DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3–26.1 is deleted in malignant brain tumours , 1997, Nature Genetics.

[12]  E. Schlaepfer,et al.  Improved In Situ Hybridization to HIV with RNA Probes Derived from PCR Products , 1997, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[13]  Y. Kim,et al.  Characterization of apomucin expression in intrahepatic cholangiocarcinomas and their precursor lesions: An immunohistochemical study , 1996, Hepatology.

[14]  P. Chambon,et al.  Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein , 1996, Science.

[15]  T. Terada,et al.  Intrahepatic peribiliary glands of humans. II. Pathological spectrum , 1994, Journal of gastroenterology and hepatology.

[16]  勝彦 齋藤,et al.  ヒト肝内胆管癌の株化(CCKS1)樹立 , 1993 .

[17]  Y. Nakanuma,et al.  Expression of blood group‐related antigens in the intrahepatic biliary tree and hepatocytes in normal livers and various hepatobiliary diseases , 1989, Hepatology.

[18]  T. Terada,et al.  Pathologic features of hepatolithiasis in Japan. , 1988, Human pathology.

[19]  D. V. van Thiel,et al.  Pregnancy-Associated Sex Steroids and Their Effects on the Liver , 1987, Seminars in liver disease.

[20]  T. Terada,et al.  Are hepatolithiasis and cholangiocarcinoma aetiologically related? , 1985, Virchows Archiv A.

[21]  M. Kojiro,et al.  Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma. A study of 57 autopsy‐proven cases , 1977, Cancer.

[22]  C. Ker,et al.  Hepatolithiasis in East Asia retrospective study , 2005, Digestive Diseases and Sciences.

[23]  T. Terada,et al.  Cell kinetic analyses and expression of carcinoembryonic antigen, carbohydrate antigen 19-9 and DU-PAN-2 in hyperplastic, pre-neoplastic and neoplastic lesions of intrahepatic bile ducts in livers with hepatoliths , 2005, Virchows Archiv A.