Consideration of albumin-mediated hepatic uptake for highly protein-bound anionic drugs: Bridging the gap of hepatic uptake clearance between in vitro and in vivo.
暂无分享,去创建一个
[1] A. D. Rodrigues,et al. Effect of Human Plasma on Hepatic Uptake of Organic Anion–Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes , 2020, Drug Metabolism and Disposition.
[2] H. Kusuhara,et al. Evaluation of hepatic uptake of OATP1B substrates by short term-cultured plated human hepatocytes: Comparison with isolated suspended hepatocytes. , 2020, Journal of pharmaceutical sciences.
[3] K. Maeda,et al. Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs , 2020, The AAPS Journal.
[4] K. Wanat. Biological barriers, and the influence of protein binding on the passage of drugs across them , 2020, Molecular Biology Reports.
[5] Yuan Chen,et al. Changes in Organic Anion Transporting Polypeptide Uptake in HEK293 Overexpressing Cells in the Presence and Absence of Human Plasma , 2019, Drug Metabolism and Disposition.
[6] Aleksandra Galetin,et al. Quantitative translation of microfluidic transporter in vitro data to in vivo reveals impaired albumin-facilitated indoxyl sulfate secretion in chronic kidney disease. , 2019, Molecular pharmaceutics.
[7] S. Haddad,et al. The potential protein-mediated hepatic uptake: discussion on the molecular interactions between albumin and the hepatocyte cell surface and their implications for the in vitro-to-in vivo extrapolations of hepatic clearance of drugs , 2019, Expert opinion on drug metabolism & toxicology.
[8] L. Benet,et al. The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation , 2019, Drug Metabolism and Disposition.
[9] L. Benet,et al. An examination of protein binding and protein‐facilitated uptake relating to in vitro‐in vivo extrapolation , 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[10] S. Klieber,et al. Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding. , 2018, Journal of pharmaceutical sciences.
[11] S. Haddad,et al. Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic Insights. , 2018, Journal of pharmaceutical sciences.
[12] Yuichi Sugiyama,et al. The Phenomenon of Albumin-Mediated Hepatic Uptake of Organic Anion Transport Polypeptide Substrates: Prediction of the In Vivo Uptake Clearance from the In Vitro Uptake by Isolated Hepatocytes Using a Facilitated-Dissociation Model , 2018, Drug Metabolism and Disposition.
[13] M. Bartolini,et al. Structural and functional integrity of human serum albumin: Analytical approaches and clinical relevance in patients with liver cirrhosis. , 2017, Journal of pharmaceutical and biomedical analysis.
[14] S. Haddad,et al. Albumin and Uptake of Drugs in Cells: Additional Validation Exercises of a Recently Published Equation that Quantifies the Albumin-Facilitated Uptake Mechanism(s) in Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling Research. , 2015, Journal of pharmaceutical sciences.
[15] P. Dawson,et al. Intestinal transport and metabolism of bile acids , 2015, Journal of Lipid Research.
[16] D. Levitt,et al. Quantitative assessment of the multiple processes responsible for bilirubin homeostasis in health and disease , 2014, Clinical and experimental gastroenterology.
[17] Toru Maruyama,et al. Albumin-drug interaction and its clinical implication. , 2013, Biochimica et biophysica acta.
[18] K. Maeda,et al. Characterization of organic anion transporting polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes. , 2012, Molecular pharmaceutics.
[19] V. Trezza,et al. Human serum albumin: from bench to bedside. , 2012, Molecular aspects of medicine.
[20] S. Haddad,et al. In vitro-in vivo extrapolation of clearance: modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods. , 2012, Journal of pharmaceutical sciences.
[21] Yuichi Sugiyama,et al. Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans , 2010, Journal of Pharmacokinetics and Pharmacodynamics.
[22] Kazuya Maeda,et al. Investigation of the Rate-Determining Process in the Hepatic Elimination of HMG-CoA Reductase Inhibitors in Rats and Humans , 2010, Drug Metabolism and Disposition.
[23] Enzo Terreno,et al. The extraordinary ligand binding properties of human serum albumin , 2005, IUBMB life.
[24] H. Halsall,et al. Binding of alpha1-acid glycoprotein to membrane results in a unique structural change and ligand release. , 2004, Biochemistry.
[25] R. Malik,et al. The relationship between the thyroid gland and the liver. , 2002, QJM : monthly journal of the Association of Physicians.
[26] D. Keppler,et al. Hepatic Uptake of Bilirubin and Its Conjugates by the Human Organic Anion Transporter SLC21A6* , 2001, The Journal of Biological Chemistry.
[27] G. Park,et al. The role of albumin in critical illness. , 2000, British journal of anaesthesia.
[28] R. Obach,et al. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[29] H. Yawo,et al. Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1* , 1999, The Journal of Biological Chemistry.
[30] M. Hnatowich,et al. Effect of binding protein surface charge on palmitate uptake by hepatocyte suspensions , 1997, British journal of pharmacology.
[31] T Iwatsubo,et al. PREDICTION OF IN VIVO DRUG DISPOSITION FROM IN VITRO DATA BASED ON PHYSIOLOGICAL PHARMACOKINETICS , 1996, Biopharmaceutics & drug disposition.
[32] Y. Sugiyama,et al. Comparison of the Hepatic Uptake Clearances of Fifteen Drugs with a Wide Range of Membrane Permeabilities in Isolated Rat Hepatocytes and Perfused Rat Livers , 1993, Pharmaceutical Research.
[33] T. Iga,et al. Effect of various organic anions on the plasma disappearance of 1-anilino-8-naphthalene sulfonate. , 1990, Journal of hepatology.
[34] D. Meijer,et al. Covalent and Noncovalent Protein Binding of Drugs: Implications for Hepatic Clearance, Storage, and Cell-Specific Drug Delivery , 1989, Pharmaceutical Research.
[35] Y. Sawada,et al. Protein-mediated hepatic uptake of rose bengal in analbuminemic mutant rats (NAR). Albumin is not indispensable to the protein-mediated transport of rose bengal. , 1988, Drug metabolism and disposition: the biological fate of chemicals.
[36] Y. Sugiyama,et al. Kinetic analysis of albumin-mediated uptake of warfarin by perfused rat liver , 1988, Journal of Pharmacokinetics and Biopharmaceutics.
[37] T. Horie,et al. Conformational change in plasma albumin due to interaction with isolated rat hepatocyte. , 1988, The American journal of physiology.
[38] P. Sluijs,et al. Lactosylation of albumin reduces uptake rate of dibromosulfophthalein in perfused rat liver and dissociation rate from albumin In Vitro , 1987, Hepatology.
[39] R. Weisiger,et al. Uptake of oleate from albumin solutions by rat liver. Failure to detect catalysis of the dissociation of oleate from albumin by an albumin receptor. , 1987, The Journal of clinical investigation.
[40] Michael S. Roberts,et al. A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations , 1986, Journal of Pharmacokinetics and Biopharmaceutics.
[41] W. Stremmel,et al. Hepatocellular uptake of oleate is energy dependent, sodium linked, and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[42] Y. Sugiyama,et al. Kinetics of hepatic transport of 4-methylumbelliferone in rats. Analysis by multiple indicator dilution method , 1985, Journal of Pharmacokinetics and Biopharmaceutics.
[43] R. Weisiger. Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[44] J. Boyer,et al. Effect of Albumin Binding on Extraction of Sulfobromophthalein by Perfused Elasmobranch Liver: Evidence for Dissociation‐Limited Uptake , 1984, Hepatology.
[45] B. Luxon,et al. Albumin-mediated transport of rose bengal by perfused rat liver. Kinetics of the reaction at the cell surface. , 1983, The Journal of clinical investigation.
[46] L. Theilmann,et al. Hepatic bilirubin uptake in the isolated perfused rat liver is not facilitated by albumin binding. , 1983, The Journal of clinical investigation.
[47] J. Lin,et al. Effects of organic anions on the uptake of 1-anilino-8-naphthalenesulfonate by isolated liver cells. , 1983, Journal of pharmaceutical sciences.
[48] C. Goresky,et al. Kinetic interpretation of hepatic multiple-indicator dilution studies. , 1983, The American journal of physiology.
[49] W. Stremmel,et al. Studies of albumin binding to rat liver plasma membranes. Implications for the albumin receptor hypothesis. , 1983, Biochimica et biophysica acta.
[50] W. Müller,et al. Characterization of an important drug binding area on human serum albumin including the high-affinity binding sites of warfarin and azapropazone. , 1982, Molecular pharmacology.
[51] B. Luxon,et al. Albumin helps mediate removal of taurocholate by rat liver. , 1981, The Journal of clinical investigation.
[52] J. Gollan,et al. Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances. , 1981, Science.
[53] H. Adlercreutz,et al. Steroid absorption and enterohepatic recycling. , 1979, Contraception.
[54] D. Eaton,et al. Carrier-mediated transport of the organic cation procaine amide ethobromide by isolated rat liver parenchymal cells. , 1978, The Journal of pharmacology and experimental therapeutics.
[55] Malcolm Rowland,et al. Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance , 1977, Journal of Pharmacokinetics and Biopharmaceutics.
[56] K. Pang,et al. Theoretic aspects of pharmacokinetic drug interactions , 1977, Clinical pharmacology and therapeutics.
[57] Gerhard Levy,et al. Serum protein binding as a determinant of warfarin body clearance and anticoagulant effect , 1976, Clinical pharmacology and therapeutics.
[58] E. Sellers,et al. Drug therapy. Binding of drugs to serum albumin (second of two parts). , 1976, The New England journal of medicine.
[59] A. Yacobi,et al. Comparative pharmacokinetics of coumarin anticoagulants. XIV: relationship between protein binding, distribution, and elimination kinetics of warfarin in rats. , 1975, Journal of pharmaceutical sciences.
[60] Grant R. Wilkinson,et al. A physiological approach to hepatic drug clearance , 1975 .
[61] L. B. Wingard,et al. Comparative pharmacokinetics of coumarin anticoagulants. X. Relationship between distribution, elimination, and anticoagulant action of warfarin. , 1974, Journal of pharmaceutical sciences.
[62] K. Baker,et al. Binding of sulfobromophthalein (BSP) sodium by plasma albumin. Its role in hepatic BSP extraction. , 1966, The Journal of clinical investigation.
[63] M. Machado,et al. New Insights About Albumin and Liver Disease. , 2018, Annals of hepatology.
[64] Kazuya Maeda,et al. Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption. , 2013, Biopharmaceutics & drug disposition.
[65] M. Otagiri,et al. A molecular functional study on the interactions of drugs with plasma proteins. , 2005, Drug metabolism and pharmacokinetics.
[66] V. Schuster. Prostaglandin transport. , 2002, Prostaglandins & other lipid mediators.
[67] K. Standing,et al. Hepatocyte [3H]-palmitate uptake: effect of albumin surface charge modification. , 2001, Canadian journal of physiology and pharmacology.
[68] Y. Sawada,et al. 'Albumin-mediated transport phenomenon' observed for ligands with high membrane permeability. Effect of the unstirred water layer in the Disse's space of rat liver. , 1992, Journal of hepatology.
[69] P. Berk,et al. Mechanisms of cellular uptake of free fatty acids. , 1989, Annual review of nutrition.
[70] S. Pond,et al. The Puzzle of Rates of Cellular Uptake of Protein-Bound Ligands , 1988 .
[71] C. Goresky. Uptake in the liver: the nature of the process. , 1980, International review of physiology.