Nutritional genomics: manipulating plant micronutrients to improve human health.

The nutritional health and well-being of humans are entirely dependent on plant foods either directly or indirectly when plants are consumed by animals. Plant foods provide almost all essential vitamins and minerals and a number of other health-promoting phytochemicals. Because micronutrient concentrations are often low in staple crops, research is under way to understand and manipulate synthesis of micronutrients in order to improve crop nutritional quality. Genome sequencing projects are providing novel approaches for identifying plant biosynthetic genes of nutritional importance. The term "nutritional genomics" is used to describe work at the interface of plant biochemistry, genomics, and human nutrition.

[1]  J. Buring,et al.  Antioxidant vitamins and cardiovascular disease. , 2009, Nutrition reviews.

[2]  J. Potter,et al.  Vegetables, fruit, and cancer prevention: a review. , 1996, Journal of the American Dietetic Association.

[3]  S. Hecht,et al.  Chemoprevention by isothiocyanates , 1995, Journal of cellular biochemistry. Supplement.

[4]  D. DellaPenna,et al.  Elevating the vitamin E content of plants through metabolic engineering. , 1998, Science.

[5]  W. Mertz.  Food fortification in the United States. , 2009, Nutrition reviews.

[6]  M. Traber,et al.  Vitamin E in humans: demand and delivery. , 1996, Annual review of nutrition.

[7]  P. Lachance.  Overview of key nutrients: micronutrient aspects. , 2009, Nutrition reviews.

[8]  T. Barrette,et al.  Genetic dissection of carotenoid synthesis in arabidopsis defines plastoquinone as an essential component of phytoene desaturation. , 1995, The Plant cell.

[9]  G. Block,et al.  Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. , 1992, Nutrition and cancer.

[10]  R. Douce,et al.  Biotin synthesis in higher plants: purification and characterization of bioB gene product equivalent from Arabidopsis thaliana overexpressed in Escherichia coli and its subcellular localization in pea leaf cells , 1997, FEBS letters.

[11]  E. Gantt,et al.  GENES AND ENZYMES OF CAROTENOID BIOSYNTHESIS IN PLANTS. , 1998, Annual review of plant physiology and plant molecular biology.

[12]  A. Harper.  Evolution of recommended dietary allowances--new directions? , 1987, Annual review of nutrition.

[13]  F. Delange,et al.  The disorders induced by iodine deficiency. , 1994, Thyroid : official journal of the American Thyroid Association.

[14]  Y. Nakamura,et al.  Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions (supplement). , 1996, DNA research : an international journal for rapid publication of reports on genes and genomes.

[15]  H. Sauberlich.  Pharmacology of vitamin C. , 1994, Annual review of nutrition.

[16]  G. Britton,et al.  Arabidopsis carotenoid mutants demonstrate that lutein is not essential for photosynthesis in higher plants. , 1996, The Plant cell.

[17]  D. DellaPenna,et al.  Complementation of the Arabidopsis pds1 mutation with the gene encoding p-hydroxyphenylpyruvate dioxygenase. , 1998, Plant physiology.

[18]  B. Underwood.  MICRONUTRIENT MALNUTRITION: Is IT BEING ELIMINATED? , 1998 .

[19]  C. Butterworth,et al.  Folic acid and the prevention of birth defects. , 1996, Annual review of nutrition.

[20]  D. Eide,et al.  A novel iron-regulated metal transporter from plants identified by functional expression in yeast. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[21]  J. Ashby.  References and Notes , 1999 .

[22]  G. Storz,et al.  Analysis of Arabidopsis mutants deficient in flavonoid biosynthesis. , 1995, The Plant journal : for cell and molecular biology.

[23]  C. Rock.  Carotenoids: biology and treatment. , 1997, Pharmacology & therapeutics.

[24]  J. H. Law,et al.  Comparative nutrition of iron and copper. , 1997, Annual review of nutrition.

[25]  N. Smirnoff,et al.  L-Ascorbic Acid Metabolism in the Ascorbate-Deficient Arabidopsis Mutant vtc1 , 1997, Plant physiology.

[26]  P. Talalay,et al.  Chemoprotection against cancer by isothiocyanates and glucosinolates. , 1996, Biochemical Society transactions.

[27]  M Caboche,et al.  Differential gene expression in Arabidopsis monitored using cDNA arrays. , 1998, The Plant journal : for cell and molecular biology.

[28]  Phenotypic Variation in Free Folic Acid Content among F1 Hybrids and Open-pollinated Cultivars of Red Beet , 1996 .

[29]  J. L. Charleux.  Beta-carotene, vitamin C, and vitamin E: the protective micronutrients. , 2009, Nutrition reviews.

[30]  M. Van Montagu,et al.  Gene discovery in the wood-forming tissues of poplar: analysis of 5, 692 expressed sequence tags. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Norman R. Farnsworth,et al.  Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes , 1997, Science.

[32]  Charles V. Smith,et al.  2 – Free Radicals in Biology: Sources, Reactivities, and Roles in the Etiology of Human Diseases , 1994 .

[33]  M. L. Brown.  Present knowledge in nutrition , 1990 .