A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells

[1]  D. M. Smith,et al.  Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes , 2016, Cell metabolism.

[2]  O. Korsgren,et al.  Positron Emission Tomography to Assess the Outcome of Intraportal Islet Transplantation , 2016, Diabetes.

[3]  P. Butler,et al.  Increased Hormone-Negative Endocrine Cells in the Pancreas in Type 1 Diabetes. , 2016, The Journal of clinical endocrinology and metabolism.

[4]  D. Accili,et al.  Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes. , 2016, The Journal of clinical endocrinology and metabolism.

[5]  Y. Saeys,et al.  Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells , 2016, Nature Communications.

[6]  C. Vanhove,et al.  Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma , 2016, The Journal of Nuclear Medicine.

[7]  M. Atkinson,et al.  Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes , 2015, Diabetes.

[8]  Nuno A. Fonseca,et al.  Expression Atlas update—an integrated database of gene and protein expression in humans, animals and plants , 2015, Nucleic Acids Res..

[9]  Guy Bormans,et al.  PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments , 2015, The Journal of Nuclear Medicine.

[10]  Dale L. Greiner,et al.  Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets , 2015, Diabetes.

[11]  M. Lubberink,et al.  Positron Emission Tomography Ligand [11C]5-Hydroxy-Tryptophan Can Be Used as a Surrogate Marker for the Human Endocrine Pancreas , 2014, Diabetes.

[12]  M. Cnop,et al.  Beta cell imaging – a key tool in optimized diabetes prevention and treatment , 2014, Trends in Endocrinology & Metabolism.

[13]  J. Tavernier,et al.  A Combined “Omics” Approach Identifies N-Myc Interactor as a Novel Cytokine-induced Regulator of IRE1α Protein and c-Jun N-terminal Kinase in Pancreatic Beta Cells* , 2014, The Journal of Biological Chemistry.

[14]  M. McCarthy,et al.  RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate , 2014, Diabetes.

[15]  S. Muyldermans,et al.  Site-specific labeling of cysteine-tagged camelid single-domain antibody-fragments for use in molecular imaging. , 2014, Bioconjugate chemistry.

[16]  S. Muyldermans,et al.  Specific Targeting of Atherosclerotic Plaques in ApoE−/− Mice Using a New Camelid sdAb Binding the Vulnerable Plaque Marker LOX-1 , 2014, Molecular Imaging and Biology.

[17]  Y. Dor,et al.  Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice , 2013, Nature Biotechnology.

[18]  J. Hecksher-Sørensen,et al.  The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells , 2013, PLoS genetics.

[19]  R. Scharfmann,et al.  Mouse Muscle As an Ectopic Permissive Site for Human Pancreatic Development , 2013, Diabetes.

[20]  J. Hecksher-Sørensen,et al.  Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes. , 2013, Developmental cell.

[21]  S. Muyldermans,et al.  Camelid single-domain antibody-fragment engineering for (pre)clinical in vivo molecular imaging applications: adjusting the bullet to its target , 2013, Expert opinion on biological therapy.

[22]  C. Mummery,et al.  Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells , 2013, Diabetes.

[23]  S. Muyldermans,et al.  Nanobodies and their potential applications. , 2013, Nanomedicine.

[24]  M. Atkinson,et al.  Formation of a human β-cell population within pancreatic islets is set early in life. , 2012, The Journal of clinical endocrinology and metabolism.

[25]  C. Lindskog,et al.  Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates. , 2012, Journal of proteomics.

[26]  Jakub Toczek,et al.  Nanobodies Targeting Mouse/Human VCAM1 for the Nuclear Imaging of Atherosclerotic Lesions , 2012, Circulation research.

[27]  M. McCarthy,et al.  The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines , 2012, PLoS genetics.

[28]  P. Meda,et al.  Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis , 2012, Diabetologia.

[29]  R. Scharfmann,et al.  A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion. , 2011, The Journal of clinical investigation.

[30]  Nick Devoogdt,et al.  Preclinical screening of anti‐HER2 nanobodies for molecular imaging of breast cancer , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[31]  E. Pauwels,et al.  Molecular imaging with SPECT as a tool for drug development. , 2011, Advanced drug delivery reviews.

[32]  C. Vanhove,et al.  Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice. , 2011, Contrast media & molecular imaging.

[33]  O. Emanuelsson,et al.  Analysis of transcript and protein overlap in a human osteosarcoma cell line , 2010, BMC Genomics.

[34]  Dennis C. Sgroi,et al.  Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes , 2010, PloS one.

[35]  S. Muyldermans,et al.  Nanobodies as Tools for In Vivo Imaging of Specific Immune Cell Types , 2010, Journal of Nuclear Medicine.

[36]  W. Oyen,et al.  Development of radiotracers for the determination of the beta-cell mass in vivo. , 2010, Current pharmaceutical design.

[37]  S. Goldman,et al.  A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)γa as a pancreatic beta cell-specific biomarker , 2010, Diabetologia.

[38]  F. Ortis,et al.  Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes , 2010, Diabetologia.

[39]  P. Herrera,et al.  Conversion of Adult Pancreatic α-cells to β-cells After Extreme β-cell Loss , 2010, Nature.

[40]  Johannes W. Dietrich,et al.  Generation of Novel Single-Chain Antibodies by Phage-Display Technology to Direct Imaging Agents Highly Selective to Pancreatic β- or α-Cells In Vivo , 2009, Diabetes.

[41]  B. Rudy,et al.  DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein , 2008, Frontiers in molecular neuroscience.

[42]  B. Rudy,et al.  Differential characterization of three alternative spliced isoforms of DPPX , 2006, Brain Research.

[43]  Jan Krützfeldt,et al.  Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. , 2005, Cell metabolism.

[44]  L. Wyns,et al.  Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies. , 2005, Journal of molecular biology.

[45]  U. Boggi,et al.  Functional and molecular defects of pancreatic islets in human type 2 diabetes. , 2005, Diabetes.

[46]  Å. Lernmark,et al.  Non-invasive imaging of beta cell mass: a quantitative analysis. , 2004, Diabetes technology & therapeutics.

[47]  C. Bernard-Kargar,et al.  Endocrine pancreas plasticity under physiological and pathological conditions. , 2001, Diabetes.

[48]  O. Pongs,et al.  Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). , 2000, Genomics.

[49]  L. Bouwens,et al.  Expression of regulatory genes for pancreas development during murine embryonic stem cell differentiation. , 2005, The International journal of developmental biology.

[50]  J. R.,et al.  Quantitative analysis , 1892, Nature.