A review of electrical impedance techniques for breast cancer detection.

Some evidence has been found that malignant breast tumors have lower electrical impedance than surrounding normal tissues. Although the separation of malignant tumors from benign lesions based on impedance measurements needs further investigation, electrical impedance could be used as an indicator for breast cancer detection. In this paper, we provide a systematic technical review of the existing electrical impedance techniques proposed for breast cancer detection, with an emphasis on noninvasive impedance imaging techniques. The electrical impedance of human breast tissue is first introduced, with tabulation of previous in vitro impedance measurement results on cancerous and normal breast tissues, and a brief description on the limited in vivo impedance measurements completed with invasive, or noninvasive, non-imaging techniques. A detailed review on noninvasive impedance imaging techniques for breast cancer detection, such as electrical impedance tomography (EIT) and electrical impedance mapping (EIM), is then presented. We suggest that for better breast cancer detection, an invasive impedance technique may be enhanced by combination with other cancer indicators. 3D EIT should be improved through collective efforts. EIM using a pair of electrode arrays is a viable method with great potential. Magnetic induction tomography and other magnetic induction based impedance imaging for breast cancer detection are promising and merit further exploration as well.

[1]  S. S. Chaudhary,et al.  Dielectric properties of normal & malignant human breast tissues at radiowave & microwave frequencies. , 1984, Indian journal of biochemistry & biophysics.

[2]  Willis J. Tompkins,et al.  Comparing Reconstruction Algorithms for Electrical Impedance Tomography , 1987, IEEE Transactions on Biomedical Engineering.

[3]  B H Blott,et al.  Electrical impedance tomography with compensation for electrode positioning variations. , 1998, Physics in medicine and biology.

[4]  John G. Webster,et al.  Electrical Impedance Tomography , 1991 .

[5]  W R Breckon,et al.  Data errors and reconstruction algorithms in electrical impedance tomography. , 1988, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[6]  J P Kaipio,et al.  Assessment of errors in static electrical impedance tomography with adjacent and trigonometric current patterns. , 1997, Physiological measurement.

[7]  A Hartov,et al.  Electrical impedance imaging at multiple frequencies in phantoms , 2000, Physiological measurement.

[8]  K. Boone,et al.  Imaging with electricity: report of the European Concerted Action on Impedance Tomography. , 1997, Journal of medical engineering & technology.

[9]  A Korjenevsky,et al.  Magnetic induction tomography: experimental realization. , 2000, Physiological measurement.

[10]  Jacqueline K. Telford,et al.  In vivo measurement of tumor conductiveness with the magnetic bioimpedance method , 2000, IEEE Transactions on Biomedical Engineering.

[11]  P. Hua,et al.  Finite element modeling of electrode-skin contact impedance in electrical impedance tomography , 1993, IEEE Transactions on Biomedical Engineering.

[12]  R. Anderson,et al.  On Electrical Impedance Scanning - Principles and Simulations , 2000 .

[13]  J. Elmore,et al.  Ten-year risk of false positive screening mammograms and clinical breast examinations. , 1998, The New England journal of medicine.

[14]  M E Valentinuzzi,et al.  Bioelectrical impedance techniques in medicine. Part I: Bioimpedance measurement. First section: general concepts. , 1996, Critical reviews in biomedical engineering.

[15]  K. Foster,et al.  Dielectric properties of tissues and biological materials: a critical review. , 1989, Critical reviews in biomedical engineering.

[16]  J Jossinet,et al.  A hardware design for imaging the electrical impedance of the breast. , 1988, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[17]  Keith D Paulsen,et al.  Imaging the breast with EIS: an initial study of exam consistency. , 2002, Physiological measurement.

[18]  R. Burns,et al.  Image-guided breast biopsy. , 1997, American journal of surgery.

[19]  H. Schwan,et al.  The Practical Success of Impedance Techniques from an Historical Perspective , 1999 .

[20]  A. Stavros,et al.  Solid breast nodules: use of sonography to distinguish between benign and malignant lesions. , 1995, Radiology.

[21]  Hermann Scharfetter,et al.  Sensitivity maps for low-contrast perturbations within conducting background in magnetic induction tomography. , 2002, Physiological measurement.

[22]  T Iritani,et al.  Measurement of the electrical bio-impedance of breast tumors. , 1990, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.

[23]  B. Blad,et al.  Impedance spectra of tumour tissue in comparison with normal tissue; a possible clinical application for electrical impedance tomography. , 1996, Physiological measurement.

[24]  T K Hames,et al.  Spectral expansion analysis in electrical impedance tomography , 1991 .

[25]  D. Malonek,et al.  The T-SCANTM technology: electrical impedance as a diagnostic tool for breast cancer detection , 2001 .

[26]  Y. Z. Ider,et al.  Electrical impedance tomography using induced and injected currents. , 1992, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[27]  R. Pethig,et al.  Dielectric properties of body tissues. , 1987, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[28]  T. Tong,et al.  Cancer statistics, 1994 , 1994, CA: a cancer journal for clinicians.

[29]  David Isaacson,et al.  Electrical Impedance Tomography , 1999, SIAM Rev..

[30]  P. Hua,et al.  Using compound electrodes in electrical impedance tomography , 1993, IEEE Transactions on Biomedical Engineering.

[31]  T Iritani,et al.  A study of the electrical bio-impedance of tumors. , 1993, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[32]  H. Schwan.  Mechanisms responsible for electrical properties of tissues and cell suspensions. , 1993, Medical progress through technology.

[33]  J. Jossinet,et al.  Impedance Modulation by Pulsed Ultrasound , 1999 .

[34]  J Jossinet,et al.  Quantitative technique for bio-electrical spectroscopy. , 1985, Journal of biomedical engineering.

[35]  D C Barber,et al.  Possibilities and problems of real-time imaging of tissue resistivity. , 1988, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[36]  Stuchly,et al.  Dielectric properties of breast carcinoma and the surrounding tissues , 1988, IEEE Transactions on Biomedical Engineering.

[37]  J P Morucci,et al.  Bioelectrical impedance techniques in medicine. Part I: Bioimpedance measurement. Second section: impedance spectrometry. , 1996, Critical reviews in biomedical engineering.

[38]  Eric McAdams,et al.  Multi-electrode systems for electrical impedance imaging , 1994 .

[39]  Keith D. Paulsen,et al.  A multichannel continuously selectable multifrequency electrical impedance spectroscopy measurement system , 2000, IEEE Transactions on Biomedical Engineering.

[40]  A Korjenevsky,et al.  A 3D electrical impedance tomography (EIT) system for breast cancer detection. , 2001, Physiological measurement.

[41]  T. Boehm,et al.  Electrical impedance scanning for classifying suspicious breast lesions: first results , 2000, European Radiology.

[42]  J Li.  A method of reducing the error caused by boundary shape and electrode positions in electrical impedance tomography. , 1994, Physiological measurement.

[43]  L C Ward,et al.  Optimizing electrode sites for segmental bioimpedance measurements , 1999, Physiological measurement.

[44]  J Jossinet,et al.  The impedivity of freshly excised human breast tissue , 1998, Physiological measurement.

[45]  D. Land,et al.  Dielectric properties of female human breast tissue measured in vitro at 3.2 GHz. , 1992, Physics in medicine and biology.

[46]  H Griffiths,et al.  Magnetic Induction Tomography: A Measuring System for Biological Tissues , 1999, Annals of the New York Academy of Sciences.

[47]  M. Eisen,et al.  Current imaging modalities for the diagnosis of breast cancer. , 1999, Delaware medical journal.

[48]  G Simonetti,et al.  What's new in mammography. , 1998, European journal of radiology.

[49]  T Iritani,et al.  Noninvasive measurement of the electrical bioimpedance of breast tumors. , 2000, Anticancer research.

[50]  A Hartov,et al.  Multifrequency electrical impedance imaging: preliminary in vivo experience in breast. , 2000, Physiological measurement.

[51]  D. Isaacson,et al.  A reconstruction algorithm for electrical impedance tomography data collected on rectangular electrode arrays , 1999, IEEE Transactions on Biomedical Engineering.

[52]  D. S. Holder.  Design and electrical characteristics of an electrode array for electrical impedance tomography of the female breast , 1995 .

[53]  JERZY WTOREK,et al.  Impedance Mammograph 3D Phantom Studies , 1999, Annals of the New York Academy of Sciences.

[54]  N.G. Gencer,et al.  Electrical impedance tomography: induced-current imaging achieved with a multiple coil system , 1996, IEEE Transactions on Biomedical Engineering.

[55]  N G Gençer,et al.  A comparative study of several exciting magnetic fields for induced current EIT. , 1994, Physiological measurement.

[56]  R. Pethig.  Dielectric Properties of Biological Materials: Biophysical and Medical Applications , 1984, IEEE Transactions on Electrical Insulation.

[57]  D. Isaacson.  Distinguishability of Conductivities by Electric Current Computed Tomography , 1986, IEEE Transactions on Medical Imaging.