On the cerebello-cerebral interactions

The question of which type of information and how it is being processed by the puzzling cerebellar circuitry remains open. Numerous works have highlighted and delineated the roles of cerebellar pathways in various parameters of motor control, such as timing of motor commands. Recent anatomical and functional data on a possible genuine cerebellar contribution in the processing of ‘cognitive’, behavioral and emotional information have not yet generated a consensus. Despite an apparent homogeneous and uniform cytoarchitecture, the actors of the cerebellar orchestra do play different roles depending on the anatomical inputs/outputs of the cerebellar regions. The numerous interactions between the cerebellum and the cerebral cortex remain a major field of research. Fundamental questions related to the cerebro-cerebellar networks, such as the modulation of corticomotoneuronal discharges in various contexts, have not been fully addressed, or only indirectly, with recent methods. Complexity of circuitries and non optimal theoretical frameworks continue to hamper our understanding of cerebellar operations.

[1]  E. Boyden,et al.  Cerebellum-dependent learning: the role of multiple plasticity mechanisms. , 2004, Annual review of neuroscience.

[2]  W. Heide,et al.  The cerebellum in the cerebro-cerebellar network for the control of eye and hand movements--an fMRI study. , 2005, Progress in brain research.

[3]  A. Koeppen,et al.  The pathogenesis of spinocerebellar ataxia , 2008, The Cerebellum.

[4]  R. Clark,et al.  Transfer of learning but not memory after unilateral cerebellar lesion in rabbits. , 1994, Behavioral neuroscience.

[5]  G. Martin,et al.  Cerebello-olivary fibers: Their origin, course and distribution in the North American opossum , 1976, Experimental Brain Research.

[6]  James M Bower,et al.  The Organization of Cerebellar Cortical Circuitry Revisited , 2002, Annals of the New York Academy of Sciences.

[7]  Y Yarom,et al.  The Olivocerebellar System as a Generator of Temporal Patterns , 2002, Annals of the New York Academy of Sciences.

[8]  Kris M. Horn,et al.  Activation of climbing fibers , 2008, The Cerebellum.

[9]  N. Ramnani.  The primate cortico-cerebellar system: anatomy and function , 2006, Nature Reviews Neuroscience.

[10]  J. Voogd,et al.  Organization of projections from the inferior olive to the cerebellar nuclei in the rat , 2000, The Journal of comparative neurology.

[11]  Mario-Ubaldo Manto,et al.  The wide spectrum of spinocerebellar ataxias (SCAs) , 2008, The Cerebellum.

[12]  C. Ekerot,et al.  Parallel fiber receptive fields: a key to understanding cerebellar operation and learning , 2008, The Cerebellum.

[13]  W. Nauta,et al.  A cerebello-olivary pathway in the cat: an experimental study using autoradiographic tracing technics. , 1973, Brain research.

[14]  D. Wolpert,et al.  Internal models in the cerebellum , 1998, Trends in Cognitive Sciences.

[15]  Dieter Jaeger,et al.  No Parallel Fiber Volleys in the Cerebellar Cortex: Evidence from Cross-Correlation Analysis between Purkinje Cells in a Computer Model and in Recordings from Anesthetized Rats , 2003, Journal of Computational Neuroscience.

[16]  M. Garwicz,et al.  Anatomical and physiological foundations of cerebellar information processing , 2005, Nature Reviews Neuroscience.

[17]  M. Pandolfo,et al.  Interaction between repetitive stimulation of the sciatic nerve and functional ablation of cerebellar nucleus interpositus in the rat , 2008, The Cerebellum.

[18]  Shigeru Obayashi,et al.  Possible mechanism for transfer of motor skill learning: implication of the cerebellum , 2008, The Cerebellum.

[19]  Masao Ito.  Cerebellar circuitry as a neuronal machine , 2006, Progress in Neurobiology.

[20]  Soichi Nagao,et al.  Pontine nuclei-mediated cerebello-cerebral interactions and its functional role , 2008, The Cerebellum.

[21]  Masahiko Fujita,et al.  Feed-forward associative learning for volitional movement control , 2005, Neuroscience Research.

[22]  Germund Hesslow,et al.  Cerebellar control of the inferior olive , 2008, The Cerebellum.

[23]  H. J. Schelhaas,et al.  Clinical, psychological, and genetic characteristics of spinocerebellar ataxia type 19 (SCA19) , 2008, The Cerebellum.

[24]  Dora E. Angelaki,et al.  Neurons compute internal models of the physical laws of motion , 2004, Nature.

[25]  D. Manzoni,et al.  The cerebellum may implement the appropriate coupling of sensory inputs and motor responses: Evidence from vestibular physiology , 2008, The Cerebellum.

[26]  Hilla Peretz,et al.  Ju n 20 03 Schrödinger ’ s Cat : The rules of engagement , 2003 .

[27]  M. Mauk,et al.  What the cerebellum computes , 2003, Trends in Neurosciences.

[28]  T. Kinoshita,et al.  Diffusion tensor imaging study of the middle cerebellar peduncles in patients with schizophrenia , 2008, The Cerebellum.

[29]  A. Luft,et al.  Modulation of motor cortex excitability by sustained peripheral stimulation: The interaction between the motor cortex and the cerebellum , 2008, The Cerebellum.

[30]  R. Miall,et al.  Behavioural aspects of cerebellar function in adults with Asperger syndrome , 2005, The Cerebellum.

[31]  M. Manto,et al.  Hemicerebellectomy impairs the modulation of cutaneomuscular reflexes by the motor cortex following repetitive somatosensory stimulation , 2006, Brain Research.

[32]  Effects of cerebellar dentate nucleus GABAergic cells on rat inferior olivary neurons , 2001, Neuroreport.

[33]  John Porrill,et al.  Report on a workshop concerning the cerebellum and motor learning, held in St Louis October 2004 , 2008, The Cerebellum.

[34]  J. Schmahmann.  Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. , 2004, The Journal of neuropsychiatry and clinical neurosciences.

[35]  Kris M. Horn,et al.  Discharge of inferior olive cells during reaching errors and perturbations , 2004, Brain Research.

[36]  Dennis J. L. G. Schutter,et al.  The cerebellum on the rise in human emotion , 2008, The Cerebellum.

[37]  Stephen M Strakowski,et al.  MRI analysis of cerebellar vermal abnormalities in bipolar disorder. , 2005, The American journal of psychiatry.

[38]  P. Strick,et al.  Activation of a cerebellar output nucleus during cognitive processing. , 1994, Science.

[39]  Joachim Hermsdörfer,et al.  Predictive and reactive finger force control during catching in cerebellar degeneration , 2008, The Cerebellum.

[40]  Mitchell Glickstein,et al.  Cerebellum lesions and finger use , 2008, The Cerebellum.

[41]  V I Nekorkin,et al.  Self-referential phase reset based on inferior olive oscillator dynamics , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[42]  J. Simpson,et al.  Microcircuitry and function of the inferior olive , 1998, Trends in Neurosciences.

[43]  R. Heath.  Modulation of emotion with a brain pacemamer. Treatment for intractable psychiatric illness. , 1977, The Journal of nervous and mental disease.

[44]  Yoshikazu Ugawa,et al.  The effects of cerebellar stimulation on the motor cortical excitability in neurological disorders: A review , 2008, The Cerebellum.