Gene conversion events between GYPB and GYPE abolish expression of the S and s blood group antigens

The locus specifying the MNS blood group system is composed of three highly homologous genes, glycophorin A (GYPA), B (GYPB) and E (GYPE). While more than 20 hybrid genes between GYPA and GYPB have been identified, no hybrid genes between GYPB and GYPE have been reported so far. We serendipitously identified GYPB‐E‐B hybrid genes by studying three individuals whose rare S−s− blood phenotype failed to be predicted by our genotyping platform.

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