Techniques: promiscuous Galpha proteins in basic research and drug discovery.

[1]  Maryse Condé Tree of Life , 1992 .

[2]  B. Conklin,et al.  Substitution of three amino acids switches receptor specificity of Gqα to that of Giα , 1993, Nature.

[3]  M. Simon,et al.  Gα15 and Gα16 Couple a Wide Variety of Receptors to Phospholipase C (*) , 1995, The Journal of Biological Chemistry.

[4]  J. Bockaert,et al.  Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. , 1996, Molecular pharmacology.

[5]  S. Rees,et al.  G16 as a universal G protein adapter: implications for agonist screening strategies. , 1996, Trends in pharmacological sciences.

[6]  H. Bourne,et al.  How receptors talk to trimeric G proteins. , 1997, Current opinion in cell biology.

[7]  S R Sprang,et al.  Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. , 1997 .

[8]  J. Bockaert,et al.  The G protein-coupling profile of metabotropic glutamate receptors, as determined with exogenous G proteins, is independent of their ligand recognition domain. , 1998, Molecular pharmacology.

[9]  J. Wess,et al.  Molecular basis of receptor/G-protein-coupling selectivity. , 1998, Pharmacology & therapeutics.

[10]  S. Rees,et al.  Chimaeric Gα proteins: their potential use in drug discovery , 1999 .

[11]  R. Lefkowitz,et al.  Heptahelical Receptor Signaling: Beyond the G Protein Paradigm , 1999, The Journal of cell biology.

[12]  C. Berlot,et al.  A surface-exposed region of G(salpha) in which substitutions decrease receptor-mediated activation and increase receptor affinity. , 2000, Molecular pharmacology.

[13]  Y. Wong,et al.  Incorporation of Galpha(z)-specific sequence at the carboxyl terminus increases the promiscuity of galpha(16) toward G(i)-coupled receptors. , 2000, Molecular pharmacology.

[14]  H. Hamm How activated receptors couple to G proteins , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[15]  C. M. Davenport,et al.  Cloning, expression, and pharmacological characterization of a novel human histamine receptor. , 2001, Molecular pharmacology.

[16]  Y. Wong,et al.  Gα14 links a variety of Gi‐ and Gs‐coupled receptors to the stimulation of phospholipase C , 2001 .

[17]  E. Kostenis Is Gα16 the optimal tool for fishing ligands of orphan G-protein-coupled receptors? , 2001 .

[18]  J. Bockaert,et al.  A Novel Site on the Gα-protein That Recognizes Heptahelical Receptors* , 2001, The Journal of Biological Chemistry.

[19]  P. Emson,et al.  AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1* , 2001, The Journal of Biological Chemistry.

[20]  J. Sondek,et al.  Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits , 2002, Nature.

[21]  Q. Shan,et al.  The C-terminus of Gi family G-proteins as a determinant of 5-HT(1A) receptor coupling. , 2002, Biochemical and biophysical research communications.

[22]  G. O'neill,et al.  Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2 , 2002, British journal of pharmacology.

[23]  P. Szekeres Functional assays for identifying ligands at orphan G protein-coupled receptors. , 2002, Receptors & channels.

[24]  Anita Preininger,et al.  Insights into G protein structure, function, and regulation. , 2003, Endocrine reviews.

[25]  L. Prézeau,et al.  The Second Intracellular Loop of Metabotropic Glutamate Receptors Recognizes C Termini of G-protein α-Subunits* , 2003, Journal of Biological Chemistry.

[26]  B. Olde,et al.  Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors. , 2003, Pharmacology & toxicology.

[27]  S. Nawoschik,et al.  Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein. , 2003, European journal of pharmacology.

[28]  M. Lohse,et al.  Gi protein activation in intact cells involves subunit rearrangement rather than dissociation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[29]  J. Chambers,et al.  The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids* , 2003, The Journal of Biological Chemistry.

[30]  R. Lefkowitz,et al.  Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ , 2003, Science.

[31]  Y. Wong,et al.  Gα 16/z Chimeras Efficiently Link a Wide Range of G Protein— Coupled Receptors to Calcium Mobilization , 2003, Journal of biomolecular screening.

[32]  S. Dowell,et al.  The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids* , 2003, The Journal of Biological Chemistry.

[33]  Hyunsu Bae,et al.  Closely Related G-protein-coupled Receptors Use Multiple and Distinct Domains on G-protein α-Subunits for Selective Coupling* , 2003, Journal of Biological Chemistry.

[34]  Y. Wong,et al.  Replacement of the α5 helix of Gα16 with Gαs-specific sequences enhances promiscuity of Gα16 toward Gs-coupled receptors , 2004 .

[35]  H. Hamm,et al.  G Protein Signaling: Insights from New Structures , 2004, Science's STKE.

[36]  Alan Wise,et al.  The identification of ligands at orphan G-protein coupled receptors. , 2004, Annual review of pharmacology and toxicology.

[37]  Y. Wong,et al.  Identification of a stretch of six divergent amino acids on the alpha5 helix of Galpha16 as a major determinant of the promiscuity and efficiency of receptor coupling. , 2004, The Biochemical journal.

[38]  Graeme Milligan,et al.  Applications of bioluminescence- and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors. , 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[39]  T. Frimurer,et al.  Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction. , 2004, Molecular pharmacology.

[40]  D. Roberts,et al.  G protein activation by G protein coupled receptors: ternary complex formation or catalyzed reaction? , 2004, Biochemical pharmacology.

[41]  A. Howlett,et al.  Chemically Distinct Ligands Promote Differential CB1 Cannabinoid Receptor-Gi Protein Interactions , 2005, Molecular Pharmacology.

[42]  J. Violin,et al.  β-Arrestin 2-Dependent Angiotensin II Type 1A Receptor-Mediated Pathway of Chemotaxis , 2005, Molecular Pharmacology.

[43]  Michel Bouvier,et al.  Real-time monitoring of receptor and G-protein interactions in living cells , 2005, Nature Methods.

[44]  P. Cassoni,et al.  The Oxytocin Receptor Antagonist Atosiban Inhibits Cell Growth via a “Biased Agonist” Mechanism* , 2005, Journal of Biological Chemistry.

[45]  S. Sprang,et al.  Structure of the p115RhoGEF rgRGS domain–Gα13/i1 chimera complex suggests convergent evolution of a GTPase activator , 2005, Nature Structural &Molecular Biology.

[46]  M. Rosenkilde,et al.  A Highly Conserved Glycine within Linker I and the Extreme C Terminus of G Protein α Subunits Interact Cooperatively in Switching G Protein-Coupled Receptor-to-Effector Specificity , 2005, Journal of Pharmacology and Experimental Therapeutics.

[47]  J. Zezula,et al.  Heterotrimeric G Protein-independent Signaling of a G Protein-coupled Receptor , 2005, Journal of Biological Chemistry.

[48]  H. Hamm,et al.  Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1*[boxs] , 2005, Journal of Biological Chemistry.

[49]  N. Riobo,et al.  Receptors coupled to heterotrimeric G proteins of the G12 family. , 2005, Trends in pharmacological sciences.

[50]  Yung Hou Wong,et al.  Chimeric and Promiscuous G Proteins in Drug Discovery and the Deorphanization of GPCRs , 2005 .

[51]  Mark H Ellisman,et al.  A FlAsH-based FRET approach to determine G protein–coupled receptor activation in living cells , 2005, Nature Methods.

[52]  Dianne M Perez From Plants to Man: The GPCR “Tree of Life” , 2005, Molecular Pharmacology.

[53]  Klaus Willecke,et al.  Identification of Specific Ligands for Orphan Olfactory Receptors , 2005, Journal of Biological Chemistry.

[54]  G. Milligan,et al.  Heterotrimeric G‐proteins: a short history , 2006, British journal of pharmacology.