Repressive BMP2 gene regulatory elements near the BMP2 promoter.

[1]  E. Hoffman,et al.  Differences in fat and muscle mass associated with a functional human polymorphism in a post‐transcriptional BMP2 gene regulatory element , 2009, Journal of cellular biochemistry.

[2]  J. Langenfeld,et al.  Mycoplasma infection transforms normal lung cells and induces bone morphogenetic protein 2 expression by post‐transcriptional mechanisms , 2008, Journal of cellular biochemistry.

[3]  T. Doetschman,et al.  Reduced expression and function of bone morphogenetic protein‐2 in bones of Fgf2 null mice , 2008, Journal of cellular biochemistry.

[4]  M. Rogers,et al.  Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factors. , 2007, Gene.

[5]  Kelly J. Chandler,et al.  Bmp2 Transcription in Osteoblast Progenitors Is Regulated by a Distant 3′ Enhancer Located 156.3 Kilobases from the Promoter , 2007, Molecular and Cellular Biology.

[6]  C. Tabin,et al.  BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing , 2006, Nature Genetics.

[7]  Sakae Tanaka,et al.  Pro-inflammatory Cytokine Tumor Necrosis Factor-α Induces Bone Morphogenetic Protein-2 in Chondrocytes via mRNA Stabilization and Transcriptional Up-regulation* , 2006, Journal of Biological Chemistry.

[8]  C. Hill Turning off Smads: identification of a Smad phosphatase. , 2006, Developmental cell.

[9]  J. Massagué,et al.  Smad transcription factors. , 2005, Genes & development.

[10]  M. Yanagita BMP antagonists: their roles in development and involvement in pathophysiology. , 2005, Cytokine & growth factor reviews.

[11]  Toshihisa Komori,et al.  Runx2 regulates FGF2‐induced Bmp2 expression during cranial bone development , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[12]  R. Kirschner,et al.  Effects of FGF-2/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential. , 2005, Bone.

[13]  Di Chen,et al.  Bone Morphogenetic Proteins , 2004, Growth factors.

[14]  H. Rubash,et al.  Osteoblast proliferation and maturation by bisphosphonates. , 2004, Biomaterials.

[15]  Lin Li,et al.  Gene regulation by Sp1 and Sp3. , 2004, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[16]  C. Nativelle-Serpentini,et al.  An Evolutionary and Molecular Analysis of Bmp2 Expression* , 2004, Journal of Biological Chemistry.

[17]  D. Soprano,et al.  Pre-B Cell Leukemia Transcription Factor (PBX) Proteins Are Important Mediators for Retinoic Acid-dependent Endodermal and Neuronal Differentiation of Mouse Embryonal Carcinoma P19 Cells* , 2004, Journal of Biological Chemistry.

[18]  L. Raftery,et al.  Gradients and thresholds: BMP response gradients unveiled in Drosophila embryos. , 2003, Trends in genetics : TIG.

[19]  F. Luyten,et al.  Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. , 2003, Arthritis and rheumatism.

[20]  W. Maloney,et al.  Stimulation of BMP-2 Expression by Pro-Inflammatory Cytokines IL-1 and TNF-&agr; in Normal and Osteoarthritic Chondrocytes , 2003, The Journal of bone and joint surgery. American volume.

[21]  Di Chen,et al.  NF-κB Specifically Activates BMP-2 Gene Expression in Growth Plate Chondrocytes in Vivo and in a Chondrocyte Cell Line in Vitro* , 2003, Journal of Biological Chemistry.

[22]  E. Birney,et al.  Comparative genomics: genome-wide analysis in metazoan eukaryotes , 2003, Nature Reviews Genetics.

[23]  Thomas A Einhorn,et al.  Fracture healing as a post‐natal developmental process: Molecular, spatial, and temporal aspects of its regulation , 2003, Journal of cellular biochemistry.

[24]  J. Briscoe,et al.  Morphogens , 2001, Current Biology.

[25]  J. Wozney,et al.  Autoregulation of mouse BMP-2 gene transcription is directed by the proximal promoter element. , 2001, Biochemical and biophysical research communications.

[26]  P. Favrel,et al.  Identification of new bone morphogenetic protein-related members in invertebrates. , 2001, Biochimie.

[27]  J Riedemann,et al.  REGULATION OF GENE EXPRESSION BY GC‐RICH DNA CIS ‐ELEMENTS , 2001, Cell biology international.

[28]  A. Geiser,et al.  Regulation of the promoters for the human bone morphogenetic protein 2 and 4 genes. , 2000, Gene.

[29]  S. Harris,et al.  Stimulation of bone formation in vitro and in rodents by statins. , 1999, Science.

[30]  L. Heller,et al.  Transcriptional Regulation of the Bmp2 Gene , 1999, The Journal of Biological Chemistry.

[31]  G. Mundy,et al.  Bone morphogenetic protein 2 transcripts in rapidly developing deer antler tissue contain an extended 5' non-coding region arising from a distal promoter. , 1997, Biochimica et biophysica acta.

[32]  A. Bradley,et al.  Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. , 1996, Development.

[33]  B. Hogan Upside-down ideas vindicated , 1995, Nature.

[34]  F. Hoffmann,et al.  Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[35]  V. Rosen,et al.  Bone morphogenetic proteins-2 and -4 are involved in the retinoic acid-induced differentiation of embryonal carcinoma cells. , 1992, Molecular biology of the cell.

[36]  V. Rosen,et al.  Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[37]  B. Hogan,et al.  Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). , 1990, Development.

[38]  B. Hogan,et al.  Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. , 1989, Genes & development.

[39]  V. Rosen,et al.  Novel regulators of bone formation: molecular clones and activities. , 1988, Science.

[40]  M. Urist Bone: Formation by Autoinduction , 1965, Science.

[41]  Joel I. Pritchard,et al.  BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect , 2003, Nature Medicine.

[42]  B. Komm,et al.  Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells. , 2003, Molecular endocrinology.

[43]  Di Chen,et al.  NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro. , 2003, The Journal of biological chemistry.

[44]  M. Rogers Receptor-selective retinoids implicate retinoic acid receptor alpha and gamma in the regulation of bmp-2 and bmp-4 in F9 embryonal carcinoma cells. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[45]  C. Tickle,et al.  Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb. , 1994, Development.

[46]  A. Economides,et al.  0163-769X/03/$20.00/0 Endocrine Reviews 24(2):218–235 Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/er.2002-0023 Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton , 2022 .