Galactosylated cucurbituril-inclusion polyplex for hepatocyte-targeted gene delivery.

The work demonstrates a judicious approach to achieve hepatocyte cell-targeted highly efficient gene delivery by utilizing a supramolecular complex of galactosylated cucurbituril and dextran-spermine conjugates.

[1]  Y. Ko,et al.  Complexation of aliphatic ammonium ions with a water-soluble cucurbit[6]uril derivative in pure water: isothermal calorimetric, NMR, and X-ray crystallographic study. , 2009, Chemistry.

[2]  Kimoon Kim Mechanically interlocked molecules incorporating cucurbituril and their supramolecular assemblies. , 2002, Chemical Society Reviews.

[3]  C. Cho,et al.  Visualization of transfection of hepatocytes by galactosylated chitosan-graft-poly(ethylene glycol)/DNA complexes by confocal laser scanning microscopy. , 2003, International journal of pharmaceutics.

[4]  S. W. Kim,et al.  Targeted polymeric gene delivery for anti-angiogenic tumor therapy , 2007 .

[5]  N. Heindel,et al.  Determination of Degree of Substitution of Formyl Groups in Polyaldehyde Dextran by the Hydroxylamine Hydrochloride Method , 1991, Pharmaceutical Research.

[6]  S. W. Kim,et al.  Soluble Flt-1 gene delivery using PEI-g-PEG-RGD conjugate for anti-angiogenesis. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[7]  N. Muzyczka Use of adeno-associated virus as a general transduction vector for mammalian cells. , 1992, Current topics in microbiology and immunology.

[8]  J. Rosenecker,et al.  Gene therapy for cystic fibrosis lung disease: current status and future perspectives. , 2006, Current opinion in molecular therapeutics.

[9]  Y. Ko,et al.  Carbohydrate wheels: cucurbituril-based carbohydrate clusters. , 2007, Angewandte Chemie.

[10]  G. Borchard Chitosans for gene delivery. , 2001, Advanced drug delivery reviews.

[11]  M. Ogris,et al.  Polylysine-based transfection systems utilizing receptor-mediated delivery. , 1998, Advanced drug delivery reviews.

[12]  Daniel W Pack,et al.  Synergistic effects in gene delivery-a structure-activity approach to the optimisation of hybrid dendritic-lipidic transfection agents. , 2008, Chemical communications.

[13]  David Eidelberg,et al.  Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial , 2007, The Lancet.

[14]  Andrew D. Miller Cationic Liposomes for Gene Therapy , 1998 .

[15]  C. Cho,et al.  Galactosylated chitosan (GC)-graft-poly(vinyl pyrrolidone) (PVP) as hepatocyte-targeting DNA carrier. Preparation and physicochemical characterization of GC-graft-PVP/DNA complex (1). , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[16]  Y. Lim,et al.  Self-assembled ternary complex of cationic dendrimer, cucurbituril, and DNA: noncovalent strategy in developing a gene delivery carrier. , 2002, Bioconjugate chemistry.

[17]  J. Benns,et al.  Tailoring New Gene Delivery Designs for Specific Targets , 2000, Journal of drug targeting.

[18]  Hao Wang,et al.  Recent developments in the use of adenoviruses and immunotoxins in cancer gene therapy , 2007, Cancer Gene Therapy.

[19]  F. Deist,et al.  Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. , 2000, Science.

[20]  D. Scherman,et al.  A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.